Polycyclic Compounds (Compounds, Polycyclic)

Compounds consisting of two or more fused ring structures.
Also Known As:
Compounds, Polycyclic; Hydrocarbons, Polycyclic; Polycyclic Hydrocarbons
Networked: 56 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Shiue, Ivy: 1 article (12/2015)
2. Sanner, Tore: 1 article (01/2015)
3. Grimsrud, Tom K: 1 article (01/2015)
4. Hamamc─▒, Dilek Asma: 1 article (01/2013)
5. Demirci, Ozlem: 1 article (01/2013)
6. Santanam, Nalini: 1 article (12/2012)
7. Brown, Kathleen C: 1 article (12/2012)
8. Cook, Carla R: 1 article (12/2012)
9. Lau, Jamie K: 1 article (12/2012)
10. Crabtree, Clayton M: 1 article (12/2012)

Related Diseases

1. Lung Neoplasms (Lung Cancer)
2. Neoplasms (Cancer)
3. Xeroderma Pigmentosum (Kaposi's Disease)
4. Hepatocellular Carcinoma (Hepatoma)
11/01/1983 - "Activation of polycyclic hydrocarbons in Reuber H4-II-E hepatoma cells. "
01/01/1982 - "We compared our data with various parameters taken from previously published results: the capacity of seven polycyclic hydrocarbons to induce aryl hydrocarbon hydroxylase (AHH) activity in human cell cultures, the capacity of 10 polycyclic hydrocarbons to induce azo dye N-demethylase activity in rat liver, the capacity of 6 polycyclic hydrocarbons to shorten zoxazolamine paralysis times in the intact rat, and the capacity of 15 benzo[a]pyrene metabolites to induce AHH activity in rat hepatoma H-4-II-E cultures. "
12/01/1990 - "Further characterization revealed the following additional differences among these three factors: (i) XF1 and XF2 could be extracted from nuclei under conditions quite different from those required for extraction of the Ah receptor; (ii) XF1 and XF2 were present in the nuclei of untreated cells and did not respond to polycyclic compounds, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and beta-napthoflavone, while nuclear Ah receptor was undetectable in untreated cells and rapidly increased in response to TCDD; (iii) inhibition of protein synthesis did not affect the TCDD-induced appearance of the Ah receptor but substantially decreased the constitutive activities of XF1 and XF2, suggesting that the Ah receptor must be present in untreated cells in an inactive form that can be rapidly activated by polycyclic compounds, while the constitutive expression of XF1 and XF2 depends on the continued synthesis of a relatively unstable protein; (iv) the receptor-deficient and nuclear translocation-defective mutants of the hepatoma cell line Hepa1, which are known to lack nuclear Ah receptor, expressed normal levels of XF1 and XF2, suggesting that the former factor is genetically distinct from the latter two; and (v) a divalent metal ion, probably Zn2+, is known to be an essential cofactor for the Ah receptor but was not required for the DNA-binding activities of XF1 and XF2. "
01/01/1982 - "differences in the rate of cellular uptake and formation of alkali-extractable metabolites of dibenzo[a,h]anthracene, 3-methylcholanthrene, and benzo[a]anthracene in Hepa-1 mouse hepatoma cell cultures do not account for differences in the capacity of these three polycyclic hydrocarbons to displace [3H]TCDD from the Ah receptor."
5. Sarcoma (Soft Tissue Sarcoma)

Related Drugs and Biologics

1. Cytochrome P-450 CYP1A1 (CYP1A1)
2. Carcinogens
3. Benzo(a)pyrene
4. Amines
5. Tetrachlorodibenzodioxin (TCDD)
6. Nitrosamines
7. DNA (Deoxyribonucleic Acid)
8. Heavy Metals
9. Smoke
10. Cytochrome P-450 Enzyme System (Cytochrome P450)