Aromatic Hydrocarbons

Organic compounds containing carbon and hydrogen in the form of an unsaturated, usually hexagonal ring structure. The compounds can be single ring, or double, triple, or multiple fused rings.

Also Known As:

Networked: 132 relevant articles (1 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Di Giulio, Richard T: 2 articles (08/2010 - 12/2004)
2.	Singh, M: 2 articles (05/2005 - 03/2001)
3.	Anisimov, Vladimir N: 1 article (11/2015)
4.	George, S C: 1 article (03/2015)
5.	Walter, M R: 1 article (03/2015)
6.	Flannery, D T: 1 article (03/2015)
7.	Hoshino, Y: 1 article (03/2015)
8.	Karczmarek-Borowska, Bożenna: 1 article (02/2015)
9.	Radziszewska, Aneta: 1 article (02/2015)
10.	Grądalska-Lampart, Monika: 1 article (02/2015)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1991 - "Studies with several bottom fish species from urban waterways show that of the identified xenobiotic chemicals in bottom sediments, polycylic aromatic hydrocarbons (PAHs) are the most strongly associated with the prevalence of liver lesions, including neoplasms. " 12/01/1986 - "Studies on the health risks of nitropolynuclear aromatic hydrocarbons and polychlorinated dibenzodioxins and dibenzofurans are reviewed, but their contribution to the overall burden of respiratory cancer in humans cannot be estimated at this time. " 07/08/2005 - "Although aromatic hydrocarbons have been extensively studied with regard to tumor formation, there has been little investigation into effects of these environmental chemicals on regulation of genes involved in tumor invasion. " 01/01/2005 - "Polycydic aromatic hydrocarbons were recorded as a causal factor of 15.4% of pulmonary, 10.6% of laryngeal, 12.8% of dermal, and 11.4% of lymphatic and hemopoietic tissue tumors, while ionising radiation for 12.8% of pulmonary, 23.1% of dermal, and 22.7% of lymphatic and hemopoietic tissue cancers. " 11/01/1999 - "Tumorigenicity of nitropolycyclic aromatic hydrocarbons in the neonatal B6C3F1 mouse bioassay and characterization of ras mutations in liver tumors from treated mice."
2.	Liver Neoplasms (Liver Cancer) 05/01/1990 - "The levels of aromatic hydrocarbons in sediments of Puget Sound, Washington, are positively correlated with the prevalence of hepatic neoplasms and related lesions in English sole (Parophrys vetulus). " 05/01/1990 - "The hypothesis that these lesions in wild English sole can be caused by exposure to certain xenobiotic hepatotoxic and hepatocarcinogenic compounds in Puget Sound is based on: a) statistical associations between levels of aromatic hydrocarbons (sigma AHs) in sediment and prevalences of these idiopathic liver lesions, b) the contribution of sigma AHs in accounting for the variability in hepatic neoplasm prevalence in a logistic regression model, c) elevated odds ratios for several idiopathic hepatic lesion types in sole from polluted sites in Puget Sound, d) significant correlations between prevalences of idiopathic hepatic lesions and levels of fluorescent metabolites of aromatic compounds (FACs) in bile of English sole, and e) experimental induction of putatively preneoplastic focal lesions in English sole injected with a PAH-enriched fraction of an extract from a contaminated urban sediment from Puget Sound, that were morphologically identical to lesions found in wild English sole from the same site." 04/01/1987 - "Statistically significant (p less than or equal to 0.05) correlations have been found between the prevalences of hepatic neoplasms in English sole and the following parameters: sediment concentrations of aromatic hydrocarbons, and concentrations of the metabolites of aromatic compounds in the bile of affected sole. " 04/01/1987 - "Laboratory studies designed to evaluate the etiology of the liver neoplasms in English sole have also yielded evidence that is consistent with the view that high molecular weight aromatic hydrocarbons, e.g., benzo[a]pyrene (BaP), are hepatocarcinogens in English sole. " 04/01/1987 - "Because levels of aromatic hydrocarbons (AHs) in urban sediments are correlated with prevalences of liver neoplasms in English sole, we have initiated detailed studies to evaluate the effects of endogenous and exogenous factors on uptake, activation and detoxication of carcinogenic AHs, such as benzo[a]pyrene (BaP), using spectroscopic, chromatographic, and radiometric techniques. "
3.	Hepatocellular Carcinoma (Hepatoma) 03/15/1998 - "Induction of CYP1A1-dependent activity in H4IIE rat hepatoma cells has been used extensively as a bioassay for halogenated aromatic hydrocarbons and more recently for PAHs. " 05/15/1996 - "Hepatic uroporphyria is a well-known effect of halo- genated aromatic hydrocarbons in mammalian and avian systems, including primary cell cultures, but attempts to produce uroporphyria in vertebrate (mammalian) hepatoma lines have been unsuccessful. " 08/08/1989 - "The present study was undertaken to determine whether choline kinase in the murine hepatoma cell line, Hepa 1c1c7, is inducible by aromatic hydrocarbons and, if so, whether this induction is mediated by the aromatic hydrocarbon receptor. " 05/01/1997 - "The H4IIE rat hepatoma cell bioassay has been extensively used to assess the toxic equivalents (TEQs) of complex mixtures of halogenated aromatic hydrocarbons in environmental samples. "
4.	Lung Injury 05/01/2007 - "Together, these results demonstrate that an extensive induction of PARP-1 might coordinate the persistent expression of proinflammatory mediators in alveolar macrophages activated by aromatic hydrocarbons that can result in lung injury from occupational exposure." 03/01/1991 - "Since a feature of chronic lung injury from aromatic hydrocarbons is an apparent alteration in target cell susceptibility, the present study was designed to test the feasibility of using microdissected pulmonary airways to evaluate the metabolism and cytotoxic response of one of the potential targets of pulmonary carcinogens, the bronchiolar Clara cell. "
5.	Congenital Abnormalities (Deformity) 10/01/2000 - "Some studies have found adverse health effects in wildlife associated with exposure to polyhalogenated aromatic hydrocarbons and altered thyroid and retinoid status including: decreased reproductive success, immune system changes, dermatologic abnormalities and developmental deformities. " 12/01/2004 - "Some PAHs have been shown to cause deformities in early life stages of fish that resemble those elicited by planar halogenated aromatic hydrocarbons (pHAHs) that are agonists for the aryl hydrocarbon receptor (AHR). "

Related Drugs and Biologics

1.	Carcinogens
2.	Estrogens (Estrogen)
3.	Phenformin (Fenformin)
4.	Nitroso Compounds
5.	Metformin (Glucophage)
6.	Buformin
7.	Biguanides
8.	Benzo(a)pyrene
9.	DNA Adducts
10.	Benzene (Benzole)

Related Therapies and Procedures

1.	Subcutaneous Injections