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Biotin (Vitamin H)

A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.

Also Known As:

Vitamin H; Biocur Brand of Biotin; Biodermatin; Biokur; Biotin Gelfert; Biotin Hermes; Biotin-ratiopharm; Biotine Roche; Deacura; Dermapharm Brand of Biotin; Gabunat; Hermes Brand of Biotin; Medea Brand of Biotin Sodium Salt; Medebiotin; Medopharm Brand of Biotin; Roche Brand of Biotin; Rombellin; Simons Brand of Biotin; Strathmann Brand of Biotin; Ziethen Brand of Biotin; e+b Pharma Brand of Biotin; medobiotin; ratiopharm Brand of Biotin; Biotin Biocur Brand; Biotin Dermapharm Brand; Biotin Hermes Brand; Biotin Medopharm Brand; Biotin Roche Brand; Biotin Simons Brand; Biotin Strathmann Brand; Biotin Ziethen Brand; Biotin ratiopharm; Biotin ratiopharm Brand; Biotinratiopharm; Gelfert, Biotin; H, Vitamin; Hermes, Biotin; Roche, Biotine; 1H-Thieno(3,4-d)imidazole-4-pentanoic acid, hexahydro-2-oxo-, (3aS-(3aalpha,4beta,6aalpha))-

Networked: 2950 relevant articles (61 outcomes, 244 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Wolf, Barry: 14 articles (10/2015 - 03/2002)
2.	Zempleni, Janos: 14 articles (12/2013 - 11/2003)
3.	Press, Oliver W: 11 articles (01/2015 - 05/2002)
4.	Wilbur, D Scott: 10 articles (12/2011 - 05/2002)
5.	Pagel, John M: 9 articles (01/2015 - 03/2003)
6.	Paganelli, Giovanni: 8 articles (04/2015 - 07/2003)
7.	Lin, Yukang: 8 articles (01/2015 - 07/2006)
8.	Kim, Jong Seung: 6 articles (11/2015 - 03/2013)
9.	Zhang, Xian-Zheng: 6 articles (10/2015 - 02/2008)
10.	Shibata, Katsumi: 6 articles (01/2015 - 12/2007)

Related Diseases

1.	Neoplasms (Cancer) 02/15/2000 - "Subsequent administration of (90)Y-1,4,7, 10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-biotin achieved peak uptake at the tumor within 2 hr while >80% of the radioactivity was eliminated in the urine. " 01/01/2015 - "Knowing that the CD44(+) is a commonly used cancer-stem-cell biomarker, our targeted biotin-MBs could be a potent tool to sort cancer stem cells from dissected tumor tissue for use in preclinical experiments and clinical trials." 01/30/2013 - "We investigated the likelihood of selecting this cell line (T47D) as an in vitro cell culture model to study biotin-conjugated anti-cancer drugs/drug delivery systems." 01/01/2010 - "In this study, cancer cells were chemically tagged with biotin and then magnetically labeled with anti-biotin SPIOs. " 10/01/2009 - "In vivo SPECT/CT imaging of xenografted PC-3 tumors in SCID mice with the three-step pretargeting method was superior to that of the two-step pretargeting method, and, importantly, blocking studies demonstrated specificity of tumor uptake of (111)In-labeled biotin in the three-step pretargeting scheme. "
2.	Biotinidase Deficiency (Multiple Carboxylase Deficiency, Late Onset) 03/04/1994 - "Biotinidase deficiency is an inherited metabolic disorder of biotin recycling that is characterized by neurological and cutaneous abnormalities, and can be successfully treated with biotin supplementation. " 10/01/2015 - "He was ultimately shown to have profound biotinidase deficiency due to a novel missense mutation and was partly improved by oral biotin therapy. " 07/01/2003 - "A follow-up of the case indicated the efficacy, of biotin supplementation in biotinidase deficiency." 12/01/1997 - "Biotinidase deficiency was confirmed biochemically and she responded well to biotin therapy. " 03/01/2015 - "Biotinidase deficiency is an autosomal recessive inborn error of biotin metabolism. "
3.	Infection 04/01/2008 - "The aim of our study is to use In-Biotin to diagnose vertebral infections. " 01/01/2015 - "During infection BplA seems primarily employed to maximize the efficiency of biotin utilization without limiting the expression of biotin biosynthetic genes, representing a novel adaptation strategy that may also be used by other intracellular pathogens. " 01/01/2015 - "Mice fed with a biotin-rich diet show significantly reduced EHEC adherence, indicating that biotin might be useful to prevent EHEC infection in humans. " 01/01/2015 - "Enterohemorrhagic Escherichia coli senses low biotin status in the large intestine for colonization and infection." 01/01/2015 - "As biotin is used as a growth factor by certain bacteria, (111)In-biotin is useful to diagnose spinal infections. "
4.	Exanthema (Rash) 04/01/2014 - "Biotin may be considereduseful for the treatment of skin rash causedby EGFR-TKIs. " 04/01/2014 - "In all patients, administration of biotin reduced the skin rash. " 05/01/1997 - "The fourth patient required a dose of 100 mg biotin/d before her skin rash disappeared. " 10/01/2001 - "Skin lesions (seborrheic rash, alopecia) were improved in our patients after biotin (10 mg/day) supplementation. " 01/01/1990 - "One child, who was not initially treated with biotin, later developed hypotonia, hair loss, and skin rash, which resolved with biotin therapy. "
5.	Carcinoma (Carcinomatosis) 01/01/2010 - "In the pre-targeting study, FM3A mouse breast carcinoma-implanted mice were injected with anti-MT1-MMP mAb-SAv, followed 72 h later with radioiodinated biotin, (3-[123/125I]iodobenzoyl)norbiotinamide (123/125I-IBB). " 10/15/2007 - "Both biotin-KCCYSL and 111In-DOTA(GSG)-KCCYSL were capable of binding ErbB-2-expressing human breast carcinoma cells in vitro. " 08/01/2002 - "CPT-PEG and CPT-PEG-biotin conjugates were synthesized and studied in vitro in A2780 sensitive and A2780/AD multidrug-resistant human ovarian carcinoma cells. " 08/01/2002 - "While biotin-pHPMA could be detected intracytoplasmically in liver and spleen, a predominantly interstitial localisation was observed within the anaplastic prostate carcinoma (Dunning R3327-AT1). " 11/01/2000 - "We have analyzed a series of 100 invasive ductal breast carcinomas without lymph node invasion both by IHC, using the CB11 monoclonal antibody and a sensitive Auidin Biotin Complex (ABC) immunodetection system, and by FISH, using the Oncor Inform HER-21neu (ERBB2) gene amplification detection system as reference technique. "

Related Drugs and Biologics

1.	Avidin
2.	Streptavidin
3.	DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)
4.	Vitamins
5.	Biotinidase
6.	Folic Acid (Vitamin M)
7.	Liposomes (Liposome)
8.	Paclitaxel (Taxol)
9.	Late-onset multiple carboxylase deficiency
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Renal Dialysis (Hemodialysis)
4.	Aftercare (After-Treatment)
5.	Subcutaneous Injections