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tanshinone

ether extract from Dan-Shen, root of Salvia miltiorrhiza Bunge; RN given refers to tanshinone I; cardioprotective agent and neuroprotective agent

Also Known As:

TTE-50; tanshinone I; tanshinone II A; tanshinone II B; tanshinone IIA; tanshinone IIB; 1,6-dimethylphenanthro(1,2-b)furan-10,11-dione

Networked: 356 relevant articles (29 outcomes, 90 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Su, Chin-Cheng: 12 articles (12/2014 - 09/2008)
2.	Xu, Min: 11 articles (02/2015 - 04/2009)
3.	Liu, Peiqing: 8 articles (07/2014 - 11/2011)
4.	Zhang, Bo: 8 articles (01/2013 - 04/2009)
5.	Zhang, Yong: 8 articles (04/2011 - 04/2009)
6.	Zhang, Li: 7 articles (01/2014 - 11/2009)
7.	Li, Jian: 6 articles (01/2016 - 11/2010)
8.	Wang, Yan: 6 articles (06/2015 - 12/2008)
9.	Kim, Sung-Hoon: 6 articles (07/2014 - 01/2010)
10.	Xu, Suowen: 6 articles (07/2014 - 11/2011)

Related Diseases

1.	Brain Ischemia (Cerebral Ischemia) 05/01/2009 - "The objective of this study was to evaluate whether Tanshinone IIA (TSA) was neuroprotective in permanent focal cerebral ischemia and to determine the possible mechanisms of its neuroprotection. " 11/20/2013 - "Interestingly, tanshinone IIA is used as a prescription drug in China to address cerebral ischemia in patients. " 09/01/2013 - "The effect of cationic albumin-conjugated PEGylated tanshinone IIA nanoparticles on neuronal signal pathways and neuroprotection in cerebral ischemia." 01/01/2013 - "Tanshinone IIA is a good candidate for treating cerebral ischemia, but its short half-life and poor permeability across the blood-brain-barrier (BBB) limit its curative efficacy. " 07/01/2010 - "To investigate the underlying neuroprotective mechanisms of Tanshinone II A (TSA) on rat cerebral ischemia in vivo. "
2.	Reperfusion Injury 04/01/2015 - "Tanshinone IIA is a lipophilic abietane diterpene compound, which exhibits protective effects against ischaemia/reperfusion injury; however, the pathways responsible for the myocardial protective activities of tanshinone IIA remain to be elucidated. " 12/01/2010 - "Tanshinone IIA may be a novel therapeutic agent for cerebral ischemia-reperfusion injury." 12/25/2012 - "The present study established a rat model of spinal cord ischemia/reperfusion injury and intraperitoneally injected Tanshinone IIa, 0.5 hour prior to model establishment. " 01/15/2015 - "Recent reports have shown that Tanshinone IIA has neuroprotective effects against cerebral ischemia/reperfusion injury and traumatic injury of the spinal cord in rats. " 07/01/2014 - "Anti-inflammatory effect of tanshinone I in neuroprotection against cerebral ischemia-reperfusion injury in the gerbil hippocampus."
3.	Ischemia 06/01/2001 - "It was found that 3. 125-200 microliters.ml-1 tanshinone possessed obvious protective effects on PC12 cells from six ischemia-like injury models. " 06/01/2001 - "To investigate the protective effects of tanshinone on ischemia-like injury models. " 01/01/2010 - "Our results showed that tanshinone IIA relieved ischemia-induced injury by improving the cardiac function. " 04/01/2015 - "In conclusion, the results of the present study indicated that JAK2/STAT3 inhibitors may enhance the protective effect of tanshinone IIA on cardiac myocytes from hypoxic ischemia-induced injury, therefore suggesting that JAK2/STAT3 inhibitors may have a potential application in combination therapies with tanshinone IIA." 04/01/2015 - "Furthermore, tanshinone IIA and JAK2/STAT3 inhibitors in combination augmented the protection of myocardial cells from apoptosis induced by ischemia/reperfusion preconditioning in vivo. "
4.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/2015 - "Although there were reports on the protective functions of tanshinone IIA (TSA) on rat myocardial ischemia, the exerting mechanism has not been completely clarified. " 05/01/2009 - "Cardioprotective effects of tanshinone IIA on myocardial ischemia injury in rats." 04/01/2011 - "Salvianolic acid B and tanshinone IIA attenuate myocardial ischemia injury in mice by NO production through multiple pathways." 01/01/2015 - "Protective effects of tanshinone IIA on myocardial ischemia reperfusion injury by reducing oxidative stress, HMGB1 expression, and inflammatory reaction." 03/08/2011 - "Tanshinone IIA (T), salvianolic acid B (S) and ginsenoside Rb1 (G) are the three major active ingredients of Compound Danshen Formula (CDF) for its protective effects on myocardial ischemia (MI). "
5.	Cardiovascular Diseases (Cardiovascular Disease) 05/01/2015 - "Tanshinone IIA (TSN) is one of the main components isolated from Danshen, which is widely used for the treatment of cardiovascular diseases. " 01/01/2014 - "Tanshinone IIA has definite protective effects on various cardiovascular diseases. " 01/01/2015 - "In this study, tanshinone extract powders from Salvia miltiorrhiza which are widely used for the treatment of cardiovascular diseases in the clinic are taken as the research object. " 11/01/2010 - "Our studies indicated that Tanshinone IIA (TanIIA), which is widely applied in the treatment of cardiovascular diseases with a rare occurrence of side effects, could promote APL cell differentiation and apoptosis. " 01/01/2016 - "Tanshinone IIA (TanIIA) is a traditional Chinese agent and has been widely used for treatment of cardiovascular diseases. "

Related Drugs and Biologics

1.	HMGB1 Protein (HMG1)
2.	Sodium
3.	salvianolic acid B
4.	Tretinoin (Retinoic Acid)
5.	tetramethylpyrazine
6.	N-Methylaspartate (NMDA)
7.	Glycogen Synthase Kinases
8.	ginsenoside Rb1
9.	salicylhydroxamic acid (SHAM)
10.	NF-kappa B (NF-kB)

Related Therapies and Procedures

1.	Radiotherapy
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Spinal Injections
4.	Aftercare (After-Treatment)
5.	Surgical Instruments (Clip)