Aromatic Polycyclic Hydrocarbons (Polycyclic Aromatic Hydrocarbons)

A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)

Also Known As:

Networked: 831 relevant articles (5 outcomes, 104 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hecht, Stephen S: 17 articles (05/2014 - 12/2002)
2.	Boffetta, Paolo: 15 articles (08/2014 - 09/2003)
3.	Perera, Frederica P: 12 articles (07/2015 - 10/2002)
4.	Carmella, Steven G: 11 articles (02/2014 - 12/2003)
5.	Lan, Qing: 10 articles (01/2015 - 11/2004)
6.	Sram, Radim J: 9 articles (02/2016 - 11/2003)
7.	Rothman, Nathaniel: 9 articles (01/2014 - 11/2004)
8.	Hochalter, J Bradley: 9 articles (03/2013 - 05/2008)
9.	He, Xingzhou: 8 articles (01/2015 - 11/2004)
10.	Teitelbaum, Susan L: 8 articles (01/2014 - 08/2002)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2011 - "Although polycyclic aromatic hydrocarbons (PAHs) are carcinogenic and have been extensively studied with regard to tumor formation, few studies have investigated the involvement of these environmental chemicals in tumor migration and invasion. " 02/01/2005 - "Previous studies of lung tumors from both non-smoking women and smoking men in this region showed high frequencies of mutations, consisting mostly of G-->T transversions in the p53 tumor suppressor gene and K-ras oncogene, suggesting that these mutations were caused primarily by polycyclic aromatic hydrocarbons. " 01/01/2000 - "The long-range goal of the present study is the development of a general approach for in vivo dosimetry of reactive metabolites of polycyclic aromatic hydrocarbons (PAHs), to be used as a tool in cancer risk assessment. " 01/01/1984 - "Animal studies have linked aryl hydrocarbon hydroxylase (AHH) with cancer induction by polycyclic aromatic hydrocarbons (PAH), but the relationship between the activation of PAH by AHH and cancer induction in man is unclear. " 02/01/2016 - "Dietary intake polycyclic aromatic hydrocarbons (PAHs) and associated cancer risk in a cohort of Chinese urban adults: Inter- and intra-individual variability."
2.	Stomach Neoplasms (Stomach Cancer) 01/01/2014 - "Polycyclic aromatic hydrocarbons and risk of gastric cancer in the Shanghai Women's Health Study." 01/01/1985 - "Frequent consumption of cured, pickled, or smoked foods, possibly because they may contain nitrosamines or polycyclic aromatic hydrocarbons, appears to increase the risk of esophageal or stomach cancer, however, the specific causative agents in these foods are not clearly identified. " 06/01/1983 - "In contrast, frequent consumption of salt-cured, salt-pickled, or smoked foods, possibly because they may contain nitrosamines or polycyclic aromatic hydrocarbons, appears to increase the risk of esophageal or stomach cancer. "
3.	Gilbert Disease 10/01/1992 - "Genetic deficiencies in bilirubin UDP-glucuronosyltransferase (GT) occur in >5% of the population (Gilbert's disease, Crigler-Najjar syndromes), and this could predispose such people to the toxic effects of polycyclic aromatic hydrocarbons and other environmental chemicals that are eliminated substantially by glucuronidation. "
4.	Lung Neoplasms (Lung Cancer) 07/01/2000 - "A mortality study on the association between lung cancer and occupational exposure to polycyclic aromatic hydrocarbons (PAHs) was carried out in a French aluminium reduction plant. " 11/01/1993 - "Exposure of pork butchers to polycyclic aromatic hydrocarbons during meat smoking, which was assessed in a contemporary study, might have contributed to their increased risk of lung cancer. " 06/01/2015 - "The interaction of APEX1 variant with polycyclic aromatic hydrocarbons on increasing chromosome damage and lung cancer risk among male Chinese." 05/01/2015 - "Polycyclic aromatic hydrocarbons: from metabolism to lung cancer." 02/01/2014 - "Exposures to polycyclic aromatic hydrocarbons (PAHs) from various environmental and occupational sources are considered a primary risk factor for lung cancer among lifelong never smokers, based largely on results from epidemiologic studies utilizing self-reported exposure information. "
5.	Breast Neoplasms (Breast Cancer) 01/01/2014 - "Previous studies suggest that polycyclic aromatic hydrocarbons (PAHs) may adversely affect breast cancer risk. " 04/01/2010 - "Previous studies have suggested that polycyclic aromatic hydrocarbons (PAHs) may be associated with breast cancer. " 10/01/1999 - "The objective of this study was to investigate whether polycyclic aromatic hydrocarbons (PAHs) contribute to the etiology of sporadic breast cancer by altering the expression of BRCA-1. " 10/01/2015 - "Polycyclic Aromatic Hydrocarbons and Breast Cancer: A Review of the Literature." 07/01/2006 - "We previously developed a historical reconstruction model to estimate exposure to airborne polycyclic aromatic hydrocarbons (PAHs) from traffic back to 1960 for use in case-control studies of breast cancer risk. "

Related Drugs and Biologics

1.	Nitrosamines
2.	Epoxy Compounds (Epoxides)
3.	Protein Isoforms (Isoforms)
4.	Sterols
5.	bilirubin glucuronoside glucuronosyltransferase
6.	lathosterol
7.	Benzo(a)pyrene
8.	Carcinogens
9.	Amines
10.	Cytochrome P-450 CYP1A1 (CYP1A1)

Related Therapies and Procedures

1.	Nuclear Power Plants
2.	Mechanical Ventilators (Ventilator)
3.	Mastectomy (Mammectomy)
4.	Renal Dialysis (Hemodialysis)
5.	Electrodes (Electrode)