Abstract | BACKGROUND: AIM: Present investigation attempts to evaluate the interrelationship between serum leptin level with body mass index, insulin and with circulating testosterone in PCOS women. SUBJECTS AND METHODS: Women diagnosed with either tubal block/male factor infertility (Control; n = 18) and with PCOS (n = 16), enrolled for in vitro fertilization and embryo transfer (IVF-ET), were recruited for this study. All were reviewed for body mass index (BMI), endocrine milieu (including pituitary gonadotropins, TSH, prolactin, gonadal steroids, and insulin) and for circulating serum leptin. Interpretation of data was done using PRISM Statistical Software Package (PRISM Version 4.03@1992-2005; GraphPad Software Inc). RESULTS: Positive correlation was observed between serum leptin, BMI, and insulin in both the groups. Mean BMI, LH, and LH: FSH ratios were found elevated in the PCOS population. PCOS women also had significantly elevated androgens and fasting levels of insulin. CONCLUSION: Hyperleptinemia in PCOS women appears to be due to the positive correlation between serum leptin, BMI, and insulin.
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Authors | J Chakrabarti |
Journal | Annals of medical and health sciences research
(Ann Med Health Sci Res)
Vol. 3
Issue 2
Pg. 191-6
(Apr 2013)
ISSN: 2141-9248 [Print] India |
PMID | 23919188
(Publication Type: Journal Article)
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