Prolactin

A lactogenic hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). It is a polypeptide of approximately 23 kD. Besides its major action on lactation, in some species prolactin exerts effects on reproduction, maternal behavior, fat metabolism, immunomodulation and osmoregulation. Prolactin receptors are present in the mammary gland, hypothalamus, liver, ovary, testis, and prostate.

Also Known As:

Networked: 8778 relevant articles (255 outcomes, 872 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Goffin, Vincent: 30 articles (03/2016 - 09/2003)
2.	Kovacs, Kalman: 30 articles (09/2014 - 01/2002)
3.	Colao, Annamaria: 23 articles (10/2014 - 06/2002)
4.	Horvath, Eva: 23 articles (09/2014 - 01/2002)
5.	Schuler, Linda A: 21 articles (01/2015 - 02/2003)
6.	Hankinson, Susan E: 19 articles (01/2015 - 02/2003)
7.	Tworoger, Shelley S: 17 articles (01/2015 - 09/2004)
8.	Scheithauer, Bernd W: 17 articles (08/2012 - 01/2003)
9.	Clevenger, Charles V: 16 articles (01/2015 - 01/2003)
10.	Trouillas, Jacqueline: 15 articles (06/2015 - 04/2003)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2014 - "Mixed GH/prolactin tumors demonstrated significantly higher remission rates, independent of variations in extrasellar growth. " 06/01/1983 - "These preliminary data suggest that a preoperative effort to reduce the size of large prolactin-secreting tumors may result in significant improvement of our surgical ventures." 04/01/2003 - "They are more effective in mixed GH/prolactin-secreting tumors. " 10/01/2012 - "Surgery was considered to be effective and remission achieved if serum prolactin was normal without DA therapy and there were no signs of tumor re-growth on neuroimaging. " 10/01/1976 - "Electron microscopical studies are helpful in identifying the tumor as source of the excessive prolactin secretion."
2.	Prolactinoma (Prolactinomas) 09/01/1980 - "This study indicates that transsphenoidal microsurgical removal of prolactinomas is highly effective for producing significant normalization of preoperative prolactin levels, resumption of menses, and the recovery of fertility in patients with microadenomas. " 04/01/1996 - "It is effective in suppressing prolactin secretion, reducing prolactinoma size and restoring gonadal function. " 10/01/1992 - "BC is known to be effective for reducing the volume of a prolactinoma and for decreasing the serum level of prolactin (PRL). " 05/01/2014 - "To study remission, defined as prolactin normalization without medical treatment, after pregnancy and lactation in women with prolactinoma. " 06/01/2015 - "A reduction in prolactin level is frequent after SRS and FSRT for prolactinomas; however, true biochemical remission is uncommon. "
3.	Hyperprolactinemia 05/01/1979 - "It appears that during hyperprolactinaemia there are defects in both positive and negative feedback of oestrogen on LH secretion, and that prolactin suppression in such patients is highly effective in restoring fertility." 01/01/2015 - "The attempts to diagnose hyperprolactinemia based on a single prolactin assay failed due to a high percentage of false negative and false positive results. " 04/01/1987 - "the prolactin secreting capacity of occulted hyperprolactinemia was significantly greater than that of the normal women. " 12/04/1990 - "The number of drugs which suppress prolactin by acting on pituitary D2 receptors, and which are useful in the treatment of hyperprolactinemia, continues to increase. " 01/01/2014 - "In other conditions, except in case of macroprolactinemia, hyperprolactinemia is secondary to circumstances that stimulate secretion of prolactin by intrinsically normal lactotroph cells, or, rarely, that are the result of decreased clearance of prolactin. "
4.	Adenoma (Adenomas) 07/01/2014 - "The patients younger than 30 years of age and those with mixed GH-prolactin secreting adenomas had significantly higher hormonal remission and lower radiological recurrence rates. " 01/01/2013 - "In patients with prolactin adenomas clinical remission was detected in 80%, and the stabilization of the disease was achieved in 15%. " 12/01/1985 - "Spontaneous reduction in size of prolactin-producing adenoma after delivery. " 12/01/1984 - "During treatment the serum prolactin concentration decreased markedly in all six patients, and in four adenoma size decreased and visual function improved. " 07/01/2014 - "Histopathological study showed mixed GH- and prolactin-secreting adenoma in 1 patient and pure GH-secreting adenoma in the other patient. "
5.	Schizophrenia (Dementia Praecox) 01/01/2000 - "The severity of psychopathology at the baseline rind subsquent improvement at the end of 3 weeks and 6 weeks was assessed on modifies brief asychiatric rating scale (BPRS).Contrary to the expectations, a two fold increase in serum prolactin level was observed in drug naive male and female patients of schizophrenia The difference was found to be statictically significant in males No correlation was observed between the baseline serum prolactin level and the severity of baseline psychopathology and subsequent improvement in psychopathology at the end of 3 weeks and 6 weeks From the present study it seems that baseline serum prolactine level in drug naive patients of schizophrenia may not be a reliable indicator of psychopathology and prognosis." 11/01/1984 - "Plasma levels and prolactin response as predictors of clinical improvement in schizophrenia: chemical v radioreceptor plasma level assays." 09/01/2014 - "The present study was to examine the relationship between serum levels of prolactin and the inflammatory status in drug-naïve, first-episode schizophrenia patients with normal weight. " 07/01/2014 - "Future studies are needed to provide the role of prolactin in schizophrenia." 01/01/2014 - "In this paper, a selective review of all relevant studies pertaining to prolactin and schizophrenia, including challenge and provocation studies, is presented. "

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8.	Estradiol (Estrace)
9.	Risperidone (Risperdal Consta)
10.	Hydrocortisone (Cortisol)

Related Therapies and Procedures

1.	Hypophysectomy
2.	Transplants (Transplant)
3.	Injections
4.	Radiotherapy
5.	Oral Administration