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Testosterone (Sustanon)

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A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.

Also Known As:

Sustanon; AndroGel; Androderm; Testim; Testoderm; 17-beta-Hydroxy-4-Androsten-3-one; 17-beta-Hydroxy-8 alpha-4-Androsten-3-one; 8-Isotestosterone; Andropatch; Androtop; AstraZeneca Brand of Testosterone; Auxilium Pharmaceuticals Inc. Brand of Testosterone; Bartor Brand of Testosterone; CEPA Brand of Testosterone; Dr. Kade Brand of Testosterone; Faulding Brand of Testosterone; Ferring Brand of Testosterone; GlaxoSmithKline Brand of Testosterone; Hauck Brand of Testosterone; Histerone; Ortho Brand of Testosterone; Paladin Brand of Testosterone; Pasadena Brand of Testosterone; Schering Brand of Testosterone; SmithKline Beecham Brand of Testosterone; Solvay Brand of Testosterone; Sterotate; Testolin; Testopel; Testosterone Sulfate; Ulmer Brand of Testosterone; Unimed Brand of Testosterone; Watson Brand of Testosterone; 17 beta Hydroxy 4 Androsten 3 one; 17 beta Hydroxy 8 alpha 4 Androsten 3 one; 8 Isotestosterone; Androst-4-en-17beta-ol-3-one

Networked: 12752 relevant articles (523 outcomes, 1623 trials/studies)

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Drug Context: Research Results

Experts

1.	Morgentaler, Abraham: 54 articles (01/2016 - 12/2003)
2.	Maggi, Mario: 51 articles (01/2016 - 05/2004)
3.	Bhasin, Shalender: 50 articles (08/2015 - 07/2002)
4.	Corona, Giovanni: 38 articles (05/2015 - 05/2006)
5.	Jones, T Hugh: 33 articles (10/2014 - 06/2002)
6.	Saad, Farid: 32 articles (09/2015 - 01/2006)
7.	Forti, Gianni: 30 articles (04/2015 - 05/2004)
8.	Basaria, Shehzad: 27 articles (08/2015 - 01/2003)
9.	Channer, Kevin S: 27 articles (12/2012 - 06/2002)
10.	Lipshultz, Larry I: 26 articles (11/2015 - 03/2002)

Related Diseases

1.	Hypogonadism (Hypergonadotropic Hypogonadism) 06/15/2011 - "Most studies demonstrate an improvement in bone mineral density in men with hypogonadism as a result of testosterone therapy. " 12/01/2000 - "Replacement therapy by parenteral or transdermal testosterone administration can be highly beneficial in alleviating the manifestations of hypogonadism and improving quality of life. " 09/01/2004 - "The availability of new treatment modalities has helped to renew interest in the management of male hypogonadism, highlighting the need to address a number of important but previously neglected questions in testosterone replacement therapy. " 11/01/1981 - "We conclude that the decrease in SHBG, which prevents obese males from developing hypogonadism, is not sufficiently effective in the massively obese patients to compensate the marked decrease in testosterone. " 01/01/2014 - "Testosterone replacement in men diagnosed with hypogonadism where mid-normal range levels are achieved have shown a beneficial effect on several cardiovascular risk factors, cardiac ischaemia, functional exercise capacity and improved mortality. "
2.	Prostatic Neoplasms (Prostate Cancer) 04/21/2015 - "(P055) can high-grade prostate cancer (Gleason 8-10) be cured with definitive local therapy without testosterone suppression? " 03/01/2009 - "Furthermore, it has been advocated that, under a rigorous surveillance, patients cured of prostate cancer can be treated with testosterone supplementation with beneficial results." 01/01/2003 - "Long-term use of these patches over the last 3 to 10 years has been effective in maintaining sexual function and bone and muscle mass, and from short-term studies it does not appear that testosterone treatment puts men at risk for the development of prostate cancer. " 11/01/2015 - "Testosterone therapy may be an effective treatment for loss of desire in both men and women, and is safe in the treatment of men who have been treated for prostate cancer. " 08/01/2011 - "For patients who still have prostate cancer which has not yet been treated or not yet cured decisions on whether the benefit of the testosterone replacement is greater than the potential risk of a progress of the disease have to be made on an individual case-specific basis."
3.	Erectile Dysfunction 03/01/2003 - "Patients given testosterone supplementation experienced a subjective improvement in their wellbeing, but reported no significant improvement in their erectile dysfunction. " 08/01/2000 - "Our meta-analysis of the usefulness of androgen replacement therapy for erectile dysfunction indicates that the response rate for a primary etiology was improved over that for a secondary etiology, transdermal testosterone therapy was more effective than intramuscular or oral treatment, and intramuscular and oral treatments were equivalent. " 04/01/2001 - "Topical treatment with cream containing testosterone and vasoactive agents may represent a new effective treatment for erectile dysfunction associating with aging." 09/01/2006 - "Although, it has been difficult to establish correlations between 'andropausal' symptoms and plasma testosterone levels, there is some evidence that testosterone replacement leads to improvement in muscle strength, bone mineral density, and erectile dysfunction. " 11/01/2002 - "Testosterone replacement improved the quality of erections and level of libido in patients with erectile dysfunction. "
4.	Body Weight (Weight, Body) 05/23/2013 - "In an initial dose-response study, SIL in a dose of 50mg/kg was the most effective in preventing the rise in prostate weight, prostate weight/body weight ratio and histopathologic changes induced by testosterone. " 05/01/2015 - "PFE at a dose of 100 mg/kg was the most effective in decreasing testosterone-induced increase in prostate weight, prostate weight/body weight ratio, and PAP levels by 30.8%, 55%, and 68% respectively and in preventing the accompanying histological changes. " 01/01/2015 - "The body weight was decreased significantly in CIS 10 mg/kg, CIS 10 mg/kg + MOTILIPERM 100 mg/kg/day, CIS 10 mg/kg + MOTILIPERM 200 mg/kg/day compared with CTR (p < 0.001) however, it was increased in CIS 10 mg/kg + MOTILIPERM 100 mg/kg/day, CIS 10 mg/kg + MOTILIPERM 200 mg/kg/day compared with CIS 10 mg/kg. The decreased weight of epididymis and prostate were increased significantly in CIS 10 mg/kg + MOTILIPERM 100 mg/kg/day compared with CIS 10 mg/kg. Sperm count, sperm motility, sperm apoptosis, MDA of testis tissue, spermatogenic cell density, Johnsen's score, and total testosterone were also significantly improved by MOTILIPERM treatment. " 01/01/2013 - "After gonadectomy and testosterone replacement, XXY mice (both sexes) still had significantly greater body weight and relative fat mass, but less relative lean mass compared to XY mice. " 12/01/1991 - "Testosterone treatment induced a significant reduction in relative bursal weight to body weight at 6 weeks of age under 16L:8D and 8 weeks of age under 16L:8D and 8L:16D, in relative thymus weight at 6 weeks of age under 16L:8D and 8L:16D, and in relative spleen weight at 6 weeks of age under 8L:16D. "
5.	Hirsutism 03/01/2007 - "At the end of the study there was a significant improvement of hirsutism, expressed in the decrease of the F-G score, accompanied by a decrease of testosterone and an increase of SHBG values. " 01/01/2006 - "At the end of the study there was a significant improvement of hirsutism, expressed in the decrease of F-G index, accompanied by an increase of testosterone and SHBG values. " 09/01/2013 - "Both treatment regimens induced a significant improvement in hirsutism score, testosterone, DHEAS, and SHBG levels. " 11/01/1991 - "Bimonthly treatment was equally effective keeping hirsutism in remission, although testosterone levels did not decrease. " 01/01/2013 - "Modified Ferriman-Gallwey hirsutism scores, testosterone levels and free androgen index improved (9.1 ± 4.2 vs 6.2 ± 3.4, P = 0.001; 80.6 ± 31.1 47.8 ± 20.3 ng/dl, P < 0.05; and 10.5 ± 7.4 vs 1.1 ± 0.8, P < 0.001, respectively). "

Related Drugs and Biologics

1.	Estradiol (Estrace)
2.	Insulin (Novolin)
3.	Gonadotropin-Releasing Hormone (GnRH)
4.	Hormones
5.	Estrogens (Estrogen)
6.	Hydrocortisone (Cortisol)
7.	Metformin (Glucophage)
8.	Dihydrotestosterone (Androstanolone)
9.	Luteinizing Hormone (Lutropin)
10.	Prolactin

Related Therapies and Procedures

1.	Castration
2.	Injections
3.	Ovariectomy (Oophorectomy)
4.	Drug Therapy (Chemotherapy)
5.	Renal Dialysis (Hemodialysis)