Gonadotropins

Hormones that stimulate gonadal functions such as GAMETOGENESIS and sex steroid hormone production in the OVARY and the TESTIS. Major gonadotropins are glycoproteins produced primarily by the adenohypophysis (GONADOTROPINS, PITUITARY) and the placenta (CHORIONIC GONADOTROPIN). In some species, pituitary PROLACTIN and PLACENTAL LACTOGEN exert some luteotropic activities.

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Networked: 3930 relevant articles (91 outcomes, 318 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Young, Jacques: 16 articles (02/2015 - 12/2003)
2.	Atwood, Craig S: 14 articles (06/2008 - 11/2002)
3.	Smith, Mark A: 12 articles (07/2014 - 11/2002)
4.	Latronico, Ana Claudia: 10 articles (03/2014 - 06/2006)
5.	Bowen, Richard L: 10 articles (06/2008 - 11/2002)
6.	Brailly-Tabard, Sylvie: 9 articles (02/2015 - 05/2009)
7.	Crowley, William F: 9 articles (11/2013 - 04/2002)
8.	Perry, George: 9 articles (01/2008 - 11/2002)
9.	Casadesus, Gemma: 8 articles (07/2014 - 01/2004)
10.	Huhtaniemi, Ilpo: 8 articles (03/2014 - 01/2003)

Related Diseases

1.	Hypogonadism (Hypergonadotropic Hypogonadism) 12/01/2002 - "Exogenous gonadotropin therapy may not be as beneficial for increasing sperm concentration in older men with idiopathic hypogonadotropic hypogonadism." 03/01/2012 - "Treatment with gonadotropins has been shown to be effective in males affected by hypogonadotropic hypogonadism. " 07/01/1980 - "Investigation of the therapeutic efficacy of menopause gonadotropin (MPG), made in the USSR, in patients with hypogonadotropic hypogonadism demonstrated MPG to possess the FSH-activity. " 12/01/2007 - "Gonadotropin therapy is a safe and effective therapy for hypogonadotropic hypogonadism." 12/01/2007 - "The objective of this study was to determine the efficacy of gonadotropin therapy in men with hypogonadotropic hypogonadism. "
2.	Precocious Puberty 01/01/1986 - "Patients with peripheral precocious puberty, however, had no significant change in gonadotropin or sex steroid levels, growth rate, or the rate of bone age maturation, and no improvement in secondary sexual characteristics. " 08/01/1991 - "A dose of more than 30 micrograms/kg of TAP-144-SR is effective in suppressing gonadotropins and causing improvement of clinical symptoms, and appears to be useful in treating children with central precocious puberty." 02/01/1986 - "Finally, the detailed characterization of children with precocious puberty has helped to define more precisely a subset of patients whose precocity occurs in the absence of demonstrable gonadotropin secretion.(ABSTRACT TRUNCATED AT 400 WORDS)" 12/01/2013 - "The aim of this study was to investigate the diagnostic accuracy of basal gonadotropin levels for girls with suspected precocious puberty and to evaluate the factors affecting positive results of the GnRHST. " 01/01/2011 - "Gonadotropin stimulation test is the gold standard to document precocious puberty. "
3.	Infertility (Sterility) 04/01/1987 - "Whereas constant administration of LHRHA by a slow release system seems very useful for long-term reversible suppression of follicular maturation, further studies should evaluate the clinical usefulness of combined LHRHA/gonadotropin treatment in cases of infertility." 11/01/1993 - "To study in a randomized and longitudinal manner the efficacy of human menopausal gonadotropin (hMG) superovulation combined with intrauterine insemination (IUI) versus IUI alone in the treatment of various causes of infertility in the presence of normal ovulation. " 01/01/2014 - "Study population consisted of 387 gonadotropin stimulated IUI cycles performed for unexplained infertility. " 10/01/2003 - "Recent studies suggest that the use of gonadotropins to induce follicular development and ovulation can decrease the severity of seasonal postpartum infertility in dairy cows." 06/01/2000 - "Study patients (n = 25) undergoing controlled ovarian hyperstimulation with intrauterine insemination infertility treatment between June 1998 and March 1999 self-administered human menopausal gonadotropin subcutaneously for ovulation induction. "
4.	Anovulation 03/01/1975 - "Gonadotropin therapy yielded good results in cases treated for anovulation (30% pregnancies) and for slight oligoasthenospermia (32.65% pregnancies). " 01/01/1983 - " Clinical trials with the formulation have shown it to be a safe and effective ultra-low dose combined OC agent whose mode of action is primarily gonadotropin suppression and subsequent anovulation." 08/01/1980 - "The purpose of this study was to determine which specific structures within the medial preoptic-anterior hypothalamic area are necessary to maintain cyclic ovulation in the rat, and to define the deifcit(s) in the feedback regulation of gonadotropin secretion associated with lesions that result in anovulation. " 01/01/1975 - "The study of longitudinal evolution of plasmatic gonadotropins in women receiving sulpirid, a psychotropic drug with a strong anti-ovulatory effect, shows the coexistence of anovulation and the peristance of a physiological pattern of gonadotropins during the first cycle of treatment. " 10/01/2012 - "Kisspeptin administration restored gonadotropin secretion and ovarian cyclicity, suggesting that kisspeptin neurons play a major role in hyperprolactinemic anovulation. "
5.	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 06/01/2004 - "Studies using pharmacological gonadotropin stimulation suggest that ovarian steroidogenesis is abnormal in the polycystic ovary syndrome (PCOS). " 12/01/1995 - "To study ovarian stimulation and response patterns during a gonadotropin step-down dose regimen for induction of ovulation by applying a decremental dose regimen in polycystic ovary syndrome (PCOS) patients. " 01/01/2015 - "Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations." 11/01/2014 - "We compared gonadotropin (Gn) administration, body mass index (BMI), the prevalence of polycystic ovary syndrome (PCOS), the number of oocytes retrieved, and the rates of clinical pregnancy, embryo implantation and OHSS incidnece between the two groups. " 07/01/2014 - "To evaluate the influence of anthropometric measurements on abnormal gonadotropin secretion in patients with polycystic ovary syndrome (PCOS). "

Related Drugs and Biologics

1.	Gonadotropin-Releasing Hormone (GnRH)
2.	Clomiphene (Clomifene)
3.	Hormones
4.	Testosterone (Sustanon)
5.	Chorionic Gonadotropin (Human Chorionic Gonadotropin)
6.	Follicle Stimulating Hormone (Follitropin)
7.	Estradiol (Estrace)
8.	Leuprolide (Lupron)
9.	Aromatase Inhibitors
10.	Gonadotropins

Related Therapies and Procedures

1.	Aftercare (After-Treatment)
2.	Diathermy
3.	Combination Drug Therapy (Combination Chemotherapy)
4.	Drug Therapy (Chemotherapy)
5.	Injections