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Insulin (Novolin)

A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Also Known As:
Novolin; Iletin; Insulin A Chain; Insulin B Chain; Insulin, Regular; Sodium Insulin; Soluble Insulin; Chain, Insulin B; Insulin, Sodium; Insulin, Soluble; Regular Insulin
Networked: 113363 relevant articles (6782 outcomes, 13622 trials/studies)

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Drug Context: Research Results

Experts

1. Asemi, Zatollah: 137 articles (01/2022 - 04/2013)
2. Shulman, Gerald I: 111 articles (01/2021 - 01/2002)
3. Kahn, C Ronald: 103 articles (06/2022 - 01/2002)
4. Holst, Jens J: 101 articles (10/2022 - 03/2002)
5. Hovorka, Roman: 97 articles (04/2022 - 01/2002)
6. Cobelli, Claudio: 95 articles (01/2022 - 02/2002)
7. Roden, Michael: 93 articles (11/2022 - 01/2002)
8. Umpierrez, Guillermo E: 91 articles (11/2022 - 01/2003)
9. DeFronzo, Ralph A: 89 articles (01/2022 - 02/2002)
10. Fritsche, Andreas: 87 articles (11/2022 - 02/2002)

Related Diseases

1. Insulin Resistance
2. Type 2 Diabetes Mellitus (MODY)
3. Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/01/2021 - "In this study, use of the tubeless insulin pump over 12 months was associated with significant improvement in A1C in adults with type 1 diabetes, most notably in those with an A1C ≥9.0% and those previously treated with MDI."
10/05/2019 - "Despite the improved management of type 1 diabetes with exogenous insulin, most patients do not meet clinical glycaemic goals, and diabetes remains an important medical problem that affects children and adults. "
01/01/2019 - "Unfortunately, this process is poorly understood, and the current best treatment for type 1 diabetes is the administration of exogenous insulin. "
09/01/2014 - "The life expectancy of Type 1 diabetes mellitus (T1DM) dramatically improved after the discovery of insulin in 1922, but was still 25 years shorter than that of non-diabetic population. "
01/01/2001 - "The main findings were as follows: (i) in type 1 diabetes, the combined analysis of GADA and IA-2A showed a sensitivity of 87.4% and was not appreciably improved by adding IAA; (ii) out of 31 adults who required insulin immediately or within the first two years of diagnosis, 41.9, 29.0, and 6.5% were positive for at least one, two or all three, and all three markers, respectively; GADA was the most prevalent (35.5%) and IA-2A the least represented (16.1%); (iii) 34 adult patients with slow evolution to insulin dependence showed a completely different profile: 5.9% were GADA positive and 23.5% were IAA positive and no double or triple positivity was observed as all patients were IA-2A negative; and (iv) 50 type 2 patients who had not required insulin treatment showed a low incidence of GADA (4%) as the only marker present. "
4. Body Weight (Weight, Body)
5. Hypoglycemia (Reactive Hypoglycemia)

Related Drugs and Biologics

1. Glucose (Dextrose)
2. Blood Glucose (Blood Sugar)
3. Lipids
4. Metformin (Glucophage)
5. Triglycerides (Triacylglycerol)
6. Hypoglycemic Agents (Hypoglycemics)
7. Cholesterol
8. Leptin
9. C-Peptide
10. Glucagon (Glukagon)

Related Therapies and Procedures

1. Therapeutics
2. Glycemic Control
3. Injections
4. Transplantation
5. Oral Administration