Steroids

A group of polycyclic compounds closely related biochemically to TERPENES. They include cholesterol, numerous hormones, precursors of certain vitamins, bile acids, alcohols (STEROLS), and certain natural drugs and poisons. Steroids have a common nucleus, a fused, reduced 17-carbon atom ring system, cyclopentanoperhydrophenanthrene. Most steroids also have two methyl groups and an aliphatic side-chain attached to the nucleus. (From Hawley's Condensed Chemical Dictionary, 11th ed)

Also Known As:

Networked: 18537 relevant articles (1470 outcomes, 1577 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Manchikanti, Laxmaiah: 55 articles (11/2015 - 01/2002)
2.	Pampati, Vidyasagar: 40 articles (02/2015 - 01/2002)
3.	Cash, Kimberly A: 35 articles (01/2015 - 05/2007)
4.	Sasano, Hironobu: 26 articles (06/2015 - 01/2002)
5.	Singh, Vijay: 21 articles (11/2015 - 01/2002)
6.	Suzuki, Takashi: 20 articles (02/2011 - 01/2002)
7.	McManus, Carla D: 18 articles (01/2015 - 05/2007)
8.	Benyamin, Ramsin M: 16 articles (11/2015 - 01/2009)
9.	Falco, Frank J E: 16 articles (01/2015 - 08/2008)
10.	Acharya, Nisha R: 16 articles (06/2014 - 01/2012)

Related Diseases

1.	Asthma (Bronchial Asthma) 06/01/2001 - "When the most recent study involving the use of the Saskatchewan databases is considered, it is evident that regular treatment with conventional or low-dose inhaled cortico-steroids results in a significant reduction in fatalities due to asthma. " 06/01/2002 - "Systemic steroids are highly effective for patients with moderate-to-severe asthma exacerbations. " 01/01/2000 - "Inhaled steroids are recognized as the most potent anti-inflammatory medication available, and they are now profiled as the cornerstone in the management of chronic persistent asthma. " 08/01/2000 - "Short-term treatment with oral steroids is very effective in control ling symptoms and improving lung function in asthma but has not been shown unequivocally to reduce bronchial hyperresponsiveness. " 07/01/1999 - "Optimal management of chronic, mild-to-moderate asthma with inhaled steroids may include use of the lowest possible doses, as recommended in guidelines, and a reduction in the frequency of daily administration for greater convenience. "
2.	Pain (Aches) 09/01/1986 - "The patient's history and a description of the pain and the corresponding neurological abnormalities present were of value in the selection of patients who were most likely to respond favorably to epidural steroids, whereas laboratory studies were not as useful. " 12/01/1994 - "Best results for the management of pain was observed in patients receiving intralesional steroids, followed by intercostal block and lumbar sympathetic block for abdominal malignancies." 01/01/2015 - "High dose steroids led to complete resolution of pain, while ptosis and ophthalmoplaegia improved gradually. " 12/01/2009 - "We report that these neuroactive steroids are very effective in alleviating peripheral nociception in both acute and chronic pain conditions in animal models of pain. " 01/01/2015 - "There was Level I evidence that local anesthetic with steroids was effective in managing chronic spinal pain based on multiple high-quality randomized controlled trials. "
3.	Inflammation 12/01/2004 - "All the adults reported had improved vision and most had resolution of inflammation, with or without topical steroids, over the course of a few months. " 01/01/2007 - "There is a certain proportion of asthmatic patients for whom long-term treatment with dry powder type steroids may not be suitable; however, their peripheral airway inflammation improved after switching them to HFA-BDP, suggesting its excellent delivery." 04/01/2012 - "Topical steroids, approved as the gold standard for non-CF NP, may be beneficial, but they are discussed to be less effective in neutrophilic inflammation,and CF-specific antimicrobial and mucolytic therapy, as is true of all treatment modalities, urgently requires evaluation by controlled clinical trials within interdisciplinary networks." 04/01/2012 - "Topical steroids, approved as the gold standard for non-CF NP, may be beneficial, but they are discussed to be less effective in neutrophilic inflammation, and CF-specific antimicrobial and mucolytic therapy, as is true of all treatment modalities, urgently requires evaluation by controlled clinical trials within interdisciplinary networks." 04/01/2003 - "Systemic steroid with a slow taper has been the established first-line treatment for idiopathic orbital inflammation, but refractory cases accounted for a significant portion of treatment failures in our study, reflecting the need for a more systematic approach to the study of this multifaceted disease and for therapeutic alternatives to systemic steroids."
4.	Proteinuria 01/01/2006 - "Steroids seem to be the best treatment for patients with proteinuria, as drugs in this class ameliorate this symptom and protect against deterioration of renal function. " 05/01/1987 - "Eighteen patients were treated with steroids; ten of these had complete remission of proteinuria and seven a significant reduction of their proteinuria. " 08/01/2010 - "She initially responded well to therapy, but later developed high-grade proteinuria while still on MMF and low-dose steroids. " 01/01/2008 - "The treatment with steroids was the only factor that forecasted a high renal survival (hazard ratio or HR: 0.07, 0.01-0.9) and proteinuria remission (HR: 0.2, 0.04-0.9). " 01/01/2004 - "Cox multivariate regression analyses showed that, in addition to steroids, a low baseline histologic score, a reduction in proteinuria after 6 mo, and no increase in proteinuria during follow-up all were independent predictors of a beneficial outcome. "
5.	Crohn Disease (Crohn's Disease) 08/01/1994 - "Steroids are highly effective in active Crohn's disease; clinical relapse following steroid withdrawal, however, is frequent. " 01/01/1992 - "Steroids are very useful drugs in the treatment of active Crohn's disease (CD), but clinical relapses after steroid withdrawal may be very high. " 08/01/1997 - "These data suggest that, in the short term, an oral elemental diet is at least as effective as steroids in inducing remission of mild-moderately active Crohn's disease, but it may be more effective in improving the nutritional status of these patients, probably through a more rapid restoration of normal intestinal permeability." 02/01/1990 - "The present study strongly suggests that elemental diet is superior to steroids for treating active Crohn's disease." 03/01/1996 - "Our meta-analysis indicated that steroids are more effective than defined-formula diets for inducing remission in active Crohn's disease. "

Related Drugs and Biologics

1.	Cyclophosphamide (Cytoxan)
2.	Anti-Bacterial Agents (Antibiotics)
3.	Cyclosporine (Ciclosporin)
4.	Azathioprine (Imuran)
5.	Adrenal Cortex Hormones (Corticosteroids)
6.	Immunosuppressive Agents (Immunosuppressants)
7.	Immunoglobulins (Immunoglobulin)
8.	Histamine Antagonists (Antihistamines)
9.	Intravenous Immunoglobulins (IVIG)
10.	Methylprednisolone

Related Therapies and Procedures

1.	Epidural Injections
2.	Drug Therapy (Chemotherapy)
3.	Injections
4.	Plasma Exchange
5.	Aftercare (After-Treatment)