Leptin

A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.

Also Known As:

Networked: 12695 relevant articles (438 outcomes, 2314 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mantzoros, Christos S: 78 articles (01/2016 - 03/2002)
2.	Myers, Martin G: 39 articles (06/2015 - 05/2003)
3.	Matarese, Giuseppe: 37 articles (09/2015 - 04/2002)
4.	Gorden, Phillip: 29 articles (01/2016 - 02/2002)
5.	Kalra, Satya P: 29 articles (12/2015 - 05/2002)
6.	Rahmouni, Kamal: 28 articles (09/2015 - 02/2002)
7.	Xue, Hui: 28 articles (08/2014 - 01/2002)
8.	Gertler, Arieh: 27 articles (06/2015 - 06/2005)
9.	Schwartz, Michael W: 27 articles (01/2015 - 03/2002)
10.	Elmquist, Joel K: 25 articles (07/2015 - 04/2002)

Related Diseases

1.	Body Weight (Weight, Body) 01/01/2014 - "However, treating obese people with exogenous leptin was unsuccessful in most cases since most of them present already high circulating leptin levels to which they do not respond anymore defining the so-called state of "leptin resistance." Indeed, leptin therapy is unsuccessful to lower body weight in commonly obese people but effective in people with rare single gene mutations of the leptin gene. " 01/01/2014 - "These results suggest that a body weight gain induced by the HFD feeding regimen significantly improved bone mass in female APP/PS1 mice with no detriments to exploration ability and spatial memory, most likely via the action of elevated circulating leptin. " 01/01/2013 - "Genetically obese females reared by lean dams showed normalized early levels of leptin and reduced body weight, food intake and body fat at adulthood; normalized estrous cycle structure and food intake across the cycle, improved hormonal profile and peripheral leptin sensitivity and a remarkable progress in self-control when exposed to a high fat/palatable diet. " 06/01/2005 - "Recent studies indicate that the passive range of motion exercise of the extremities results in a significantly greater increase of body weight, increased bone mineralization, increased bone formation markers and leptin levels, and attenuation of the natural post-natal decline in bone SOS. " 05/01/2002 - "In the present study, we tested the hypothesis that a single daily injection of the gut peptide CCK, together with continuous leptin infusion, would produce significantly greater loss of body weight than leptin alone. "
2.	Obesity 04/18/2011 - "The interaction with leptin, which is thought to involve the hypothalamus, may have important implications for the development of new and improved hormonal anti-obesity treatments. " 01/11/2006 - "Absence of MCH neurons in ob/ob mice improved obesity, diabetes, and hepatic steatosis, suggesting that MCH neurons are important mediators of the response to leptin deficiency. " 09/01/2004 - "A more complete understanding of the molecular components of the leptin pathway is necessary to develop effective treatment for obesity and the Metabolic Syndrome. " 12/01/2003 - "A more complete understanding of the molecular components of the leptin pathway is necessary to develop effective treatment for obesity and the Metabolic Syndrome. " 04/01/2003 - "Changes in the biological efficacy of leptin were evaluated in obesity-resistant (A/J) and obesity-prone (C57BL/6J) mice at weaning and after consuming a high-fat (HF) diet for 4 and 8 wk. There was no evidence of leptin resistance in either strain at the start of the study, but after 4 and 8 wk on the HF diet, C57BL/6J mice became unresponsive to ip leptin. "
3.	Insulin Resistance 04/01/2005 - "We found no difference in cardiac indices, insulin resistance, body composition and leptin levels between patients with complete biochemical remission and those with inadequately controlled disease (P > 0.05 for all) after TSS. " 12/01/2008 - "And the simultaneous measurement of insulin resistance and leptin concentration might be helpful for screening subjects with a high-risk of CAD." 01/01/2008 - "Long-term recombinant leptin therapy is effective in treating the insulin resistance of patients with the unusual combination of T1D and AGL." 10/01/2011 - "Furthermore, walking improved insulin resistance and decreased body fat while lowering serum levels of leptin." 06/01/2011 - "Our findings may help to elucidate the effects of leptin on insulin resistance."
4.	Weight Loss (Weight Reduction) 05/01/1998 - "Exogenous administration of leptin to ob/ob mice leads to a significant improvement in reproductive and endocrine status as well as reduced food intake and weight loss. " 05/04/2007 - "Blocking central IL1 signaling also did not alter the re-feeding response to a prolonged fast, yet was entirely effective in preventing the anorexic effect of exogenously administered leptin (2 mg/kg ip, cumulative food intake at 18 h AdV-IL1ra 30.5+/-1.1 g vs. VEH 26.4+/-1.7 g, p<0.05) and prevented leptin-induced weight loss (AdV-IL1ra -0.1+/-1.3 g vs. VEH -2.7+/-1.9 g, p<0.05). " 12/01/2010 - "Weight loss (average 50% excess weight) was associated with a 14% improvement in PWV (P = 0.03), and with reductions in serum leptin levels (P < 0.01). " 04/01/2006 - "It has been shown that the administration of leptin in congenital leptin deficiency that there was improvement in satiety and weight loss. " 11/01/2001 - "Administration of leptin to ob/ob mice led to improved reproduction as well as reduced feed intake and weight loss. "
5.	Weight Gain 09/15/2004 - "Likewise, serum leptin levels, which were highly correlated with weight gain, also showed significantly greater increases in left amygdaloid kindled rats relative to rats kindled from the right amygdala and control rats. " 06/01/2008 - "Kinin B(1) receptor deficiency in mice (B(1)(-/-)) resulted in less fat content, hypoleptinemia, increased leptin sensitivity, and robust protection against high-fat diet-induced weight gain. " 03/01/2008 - "Second, we examined if voluntary wheel running is beneficial in reducing the trajectory of weight gain in high-fat-raised leptin-resistant rats. " 12/01/1996 - "The rapid increase in serum leptin levels observed in some Ctx subjects suggests that early postoperative measurement of serum leptin levels may help to identify patients at risk of weight gain following hypothalamic destruction." 07/01/2005 - "For the first time we show the persistent efficacy of central leptin gene therapy to suppress weight gain through all phases of reproduction, lactation and post-lactation in dams and reveal the potential imprinting link to producing lower weight in the F1 generation."

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Glucose (Dextrose)
3.	Adiponectin
4.	Resistin
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Triglycerides (Triacylglycerol)
7.	Blood Glucose (Blood Sugar)
8.	Hormones
9.	Leptin Receptors
10.	Adipokines

Related Therapies and Procedures

1.	Caloric Restriction
2.	Bariatric Surgery
3.	Injections
4.	Gastric Bypass (Roux-en-Y Gastric Bypass)
5.	Gastrectomy