Antiviral drugs in current clinical use.

Abstract

The current armamentarium for the chemotherapy of viral infections consists of 37 licensed antiviral drugs. For the treatment of human immunodeficiency virus (HIV) infections, 19 compounds have been formally approved: (i) the nucleoside reverse transcriptase inhibitors (NRTIs) zidovudine, didanosine, zalcitabine, stavudine, lamivudine, abacavir and emtricitabine; (ii) the nucleotide reverse transcriptase inhibitor (NtRTI) tenofovir disoproxil fumarate; (iii) the non-nucleoside reverse transcriptase inhibitors (NNRTIs) nevirapine, delavirdine and efavirenz; (iv) the protease inhibitors saquinavir, ritonavir, indinavir, nelfinavir, amprenavir, lopinavir (combined with ritonavir at a 4/1 ratio) and atazanavir; and the viral entry inhibitor enfuvirtide. For the treatment of chronic hepatitis B virus (HBV) infections, lamivudine as well as adefovir dipivoxil have been approved. Among the anti-herpesvirus agents, acyclovir, valaciclovir, penciclovir (when applied topically), famciclovir, idoxuridine and trifluridine (both applied topically) as well as brivudin are used in the treatment of herpes simplex virus (HSV) and/or varicella-zoster virus (VZV) infections; and ganciclovir, valganciclovir, foscarnet, cidofovir and fomivirsen (the latter upon intravitreal injection) have proven useful in the treatment of cytomegalovirus (CMV) infections in immunosuppressed patients (i.e. AIDS patients with CMV retinitis). Following amantadine and rimantadine, the neuraminidase inhibitors zanamivir and oseltamivir have recently become available for the therapy (and prophylaxis) of influenza virus infections. Ribavirin has been used (topically, as aerosol) in the treatment of respiratory syncytial virus (RSV) infections, and the combination of ribavirin with (pegylated) interferon-alpha has received increased acceptance for the treatment of hepatitis C virus (HCV) infections.

• Authors: Erik De Clercq
• Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology (J Clin Virol) Vol. 30 Issue 2 Pg. 115-33 (Jun 2004) ISSN: 1386-6532 [Print] Netherlands
• PMID: 15125867 (Publication Type: Journal Article, Review)

Chemical References

• Anti-HIV Agents
• Antiviral Agents
• HIV Protease Inhibitors
• Reverse Transcriptase Inhibitors
• HIV Protease

Topics

• Anti-HIV Agents (chemistry, therapeutic use)
• Antiviral Agents (classification, therapeutic use)
• Cytomegalovirus Infections (drug therapy)
• HIV Protease (chemistry)
• HIV Protease Inhibitors (chemistry, therapeutic use)
• Hepatitis B (drug therapy)
• Herpes Simplex (drug therapy)
• Humans
• Molecular Conformation
• Reverse Transcriptase Inhibitors (chemistry, therapeutic use)
• Virus Diseases (drug therapy)