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Interferon-alpha (Interferon Alfa)

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One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.

Also Known As:

Interferon Alfa; Glaxo Wellcome Brand of Interferon alfa-n1; Interferon Alfa-n1; Interferon Alfa-n3; Interferon, Lymphoblastoid; Interferon, alpha; Wellferon; Glaxo Wellcome Brand of Interferon alfa n1; Interferon Alfa n1; Interferon Alfa n3; Interferon alpha; Leukocyte Interferon; Lymphoblast Interferon; Lymphoblastoid Interferon; alpha Interferon; Interferon, Leukocyte; Interferon, Lymphoblast; alpha-Interferon

Networked: 10282 relevant articles (1135 outcomes, 1548 trials/studies)

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Drug Context: Research Results

Experts

1.	Zeuzem, Stefan: 29 articles (10/2014 - 04/2002)
2.	Nagano, Hiroaki: 26 articles (12/2013 - 01/2002)
3.	Berg, Thomas: 25 articles (01/2015 - 12/2002)
4.	Umeshita, Koji: 25 articles (12/2013 - 01/2002)
5.	Monden, Morito: 23 articles (11/2008 - 01/2002)
6.	Manns, Michael P: 22 articles (11/2015 - 01/2002)
7.	Zeuzem, S: 22 articles (04/2013 - 01/2000)
8.	Dono, Keizo: 22 articles (11/2008 - 01/2002)
9.	Sarrazin, Christoph: 21 articles (01/2014 - 12/2002)
10.	Motzer, Robert J: 19 articles (08/2014 - 01/2002)

Related Diseases

1.	Chronic Hepatitis C 02/01/1999 - "Interferon-alfa treatment is the only licensed therapy for chronic hepatitis C until now, but an efficacy of such treatment is highly variable. " 04/01/1996 - "Some patients with chronic hepatitis C are very sensitive to alpha interferon and can be successfully treated with low doses. " 02/01/1996 - "Alpha interferon (IFN-alpha) is, to date, the only treatment with proven efficacy in patients with chronic hepatitis C. " 02/01/1993 - "Interferon-alpha (IFN-alpha) has proven useful in the treatment of chronic hepatitis C, but a relapse in response is frequently observed. " 09/01/1992 - "Interferon-alpha therapy is of proven efficacy in chronic hepatitis C, but it is not universally effective and may be associated with intolerable side effects. "
2.	Infection 04/01/2008 - "Antibody, interferon-alpha, polyICLC and other immune modulators are highly effective when administered before or within a narrow time window after infection, but are ineffective when given after the infection is established. " 05/08/2002 - "However, recent data suggest that early treatment of acute HCV infection with interferon alpha may be highly effective in preventing chronic HCV infection. " 05/01/1996 - " The most effective treatment of chronic infection, alpha interferon, is associated with a relapse rate of 80-90%. " 09/01/2013 - "Interferon-alpha (IFN-α), an active cytokine, plays an important role in antiviral host responses, including protection against hepatitis B virus (HBV) infection. " 06/01/2013 - "Early treatment of acute hepatitis C virus (HCV) infection with interferon alfa monotherapy is very effective, with cure rates of greater than 85%. "
3.	Chronic Hepatitis B 05/01/1998 - "Since interferon alpha administration has proven effective in chronic hepatitis-B therapy, we decided to administer interferon alpha 2a (13,46,47,55). " 09/01/2008 - "Interferon-alpha treatment tailored in length demonstrated significantly increased efficacy in patients with chronic hepatitis B." 09/01/2000 - "The only agent known to have a lasting beneficial effect in chronic hepatitis B is interferon alpha, which achieves long-term remission in 25-40% of the patients. " 11/01/1999 - "Efficacy of high dose interferon--alpha treatment of chronic hepatitis B." 11/01/1998 - "Alpha-interferon (IFN-alpha) is an effective treatment for chronic hepatitis B but only 25-40% of patients will profit from a long-term beneficial response to the currently recommended schedule of 3-6 MU given 3 times a week for 6 months. "
4.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/01/2004 - "In June 2002, he was diagnosed as having the chronic phase of chronic myelogenous leukemia (CML), and following treatment with interferon-alpha, he achieved hematological complete remission. " 01/01/2002 - "Follow-up of complete cytogenetic remission in patients with chronic myeloid leukemia after cessation of interferon alfa." 04/01/1998 - "Interferon alfa (IFN-alpha) induces complete cytogenetic remission in a significant minority of patients with chronic myelogenous leukemia (CML). " 09/06/1997 - "[Fluctuating molecular remission in patients with chronic myeloid leukemia with long term complete cytogenetic response after alpha interferon treatment]." 12/01/1994 - "Interferon-alpha has been used for chronic myeloid leukemia patients and may achieve hematological and cytogenetic complete remission. "
5.	Renal Cell Carcinoma (Grawitz Tumor) 05/01/2009 - "Efficacy of adjuvant interferon-alpha therapy following curative resection in renal cell carcinoma: before the molecular targeting therapy era." 08/15/2001 - "Interferon-alpha has proven effective in the treatment of metastatic renal cell carcinoma. " 07/07/2003 - "Rapid deterioration in quality of life during interleukin-2- and alpha-interferon-based home therapy of renal cell carcinoma is associated with a good outcome." 06/01/2010 - "A systematic review was undertaken to determine whether interferon-alfa (IFN-alpha) is an effective treatment for patients with inoperable locally advanced or metastatic renal cell carcinoma (mRCC). " 04/01/2006 - "Interferon-alpha (IFN) is widely used for the treatment of progressive renal cell carcinoma (RCC), but its effective response rate is only about 15%. "

Related Drugs and Biologics

1.	Ribavirin (Virazole)
2.	Interferons
3.	Interleukin-2 (IL2)
4.	Hepatitis B e Antigens
5.	Lamivudine (3TC)
6.	Fluorouracil (Carac)
7.	RNA (Ribonucleic Acid)
8.	Interferon-alpha (Interferon Alfa)
9.	Antigens
10.	Zidovudine (Retrovir)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Aftercare (After-Treatment)
3.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
4.	Retreatment
5.	Transplants (Transplant)