Neuraminidase (Sialidase)

An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)

Also Known As:

Networked: 3440 relevant articles (177 outcomes, 280 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hurt, Aeron C: 33 articles (11/2015 - 01/2003)
2.	Gubareva, Larisa V: 32 articles (10/2015 - 07/2004)
3.	Boivin, Guy: 29 articles (11/2015 - 03/2002)
4.	Miyagi, Taeko: 26 articles (01/2016 - 01/2002)
5.	Abed, Yacine: 22 articles (02/2015 - 08/2002)
6.	Webster, Robert G: 21 articles (11/2015 - 08/2002)
7.	Suzuki, Yasuo: 21 articles (10/2015 - 10/2003)
8.	Kawaoka, Yoshihiro: 21 articles (05/2015 - 07/2003)
9.	Yamaguchi, Kazunori: 20 articles (10/2015 - 08/2002)
10.	von Itzstein, Mark: 19 articles (03/2015 - 08/2004)

Related Diseases

1.	Human Influenza (Influenza) 11/08/2013 - "A monoclonal antibody targeting a highly conserved epitope in influenza B neuraminidase provides protection against drug resistant strains." 02/01/2006 - "These results highlight the striking difference between the influenza neuraminidase and paramyxovirus HN active sites, and provide a platform for the development of improved HN inhibitors." 01/01/2007 - "Neuraminidase inhibitors are effective in shortening illness duration in healthy children with influenza, but efficacy in 'at risk' children remains to be proven. " 03/01/2010 - "Neuraminidase inhibitors beneficial for treatment and prevention of influenza in children." 03/01/2008 - "Of the total number of viruses analysed, only 2 (0.2%) strains (an A(H1N1) strain and an influenza B strain) were considered to have a significant reduction in sensitivity to at least one of the neuraminidase inhibitor drugs. "
2.	Infection 12/01/2014 - "Infection of influenza virus neuraminidase-vaccinated mice with homologous influenza virus leads to strong protection against heterologous influenza viruses." 08/01/1968 - "Protective effects of specific immunity to viral neuraminidase on influenza virus infection of mice." 08/01/2013 - "Neuraminidase (NA)-related immunity contributes to protection against influenza virus infection. " 01/01/2012 - "We propose that neuraminidase from bacterial flora in patients may reduce the efficacy of NA inhibitor drugs during influenza virus infection. " 10/01/2005 - "We examined the efficacy of neuraminidase inhibitors for reducing the duration of virus shedding after naturally occurring influenza virus infection. "
3.	Neoplasms (Cancer) 03/01/1977 - "The problems of alteration of antigenicity and of other properties of cells through splitting off membrane-bound neuraminic acid, the facts of adjuvanticity of neuraminidase itself, the relation of successful therapy to dose dependency as well as the relation of undesirable methods for tumor mass reduction to the immunological responsiveness of the tumor bearer were especially looked into." 11/01/2007 - "On the whole, the results demonstrate that the bigger, but not the smaller, dose of neuraminidase was markedly effective in preserving the vitality of blood lymphocytes and in decreasing both the number of apoptotic lymphocytes and capsase-3 activity in the rats with Morris tumor. " 08/01/1981 - "Characterization and use of neuraminidase-modified L1210 plasma membranes for protection against tumor growth." 11/01/2007 - "In conclusion, the study demonstrates that neuraminidase caused an appreciable decline in apoptosis of blood lymphocytes in rats with the Morris tumor; the effect was dose-dependent. " 11/01/2007 - "In this study we examined the influence of neuraminidase on apoptosis of peripheral blood lymphocytes in rats with an implanted Morris tumor. "
4.	Influenza in Birds (Avian Flu) 01/01/2011 - "We have identified and characterized an H5N1 neuraminidasespecific monoclonal antibody which specifically inhibits N1 neuraminidase activity of highly pathogenic avian influenza (HPAI) strains from clades 1 and 2. We have also shown the protective efficacy of this antibody in animal challenge models using homologous virus. " 04/01/2014 - "In this study, the neuraminidase (NA) gene of three Avian Influenza (AI) H9N2 strains isolated from poultry farms in Iran during 2010-11, as well as other reported Iranian H9N2 isolates, were genetically analyzed and their nucleotide changes were evaluated. " 01/01/2013 - "In this study, 9 pairs of primers were designed with PrimerHunter and successfully used to differentiate the 9 neuraminidase (NA) genes of avian influenza viruses (AIVs) in multiple PCR-based assays. " 03/15/2012 - "Synthesis and in vitro study of novel neuraminidase inhibitors against avian influenza virus." 06/20/2011 - "High-throughput neuraminidase substrate specificity study of human and avian influenza A viruses."
5.	Pneumonia (Pneumonitis) 05/01/2015 - "The interval from illness onset to administration of neuraminidase inhibitors was 1.8 ± 1.1 days in cases with pneumonia and 2.1 ± 1.5 days in cases without pneumonia. " 01/01/2014 - "Ervaticine (-6.42), 5-oxo-11-hydroxy voaphylline (-6.18), Conolobine B (-6.02) has found optimum binding against the active site of NanB sialidase of Streptococcus pneumonia. " 01/01/2011 - "The annotated genome of strain M129 (GenBank NC_000912, ATCC 29342), also isolated from a patient with pneumonia, accurately represents the absence of sialidase genes from strains of M. " 01/01/2011 - "Retrospective survey for sialidase activity in Mycoplasma pneumoniae isolates from cases of community-acquired pneumonia." 09/01/2009 - "None of the 18 patients undergoing neuraminidase inhibitor therapy died, but two of three patients who did not receive this therapy died from complications of advanced pneumonia. "

Related Drugs and Biologics

1.	Oseltamivir (Tamiflu)
2.	Zanamivir (Relenza)
3.	Hemagglutinins (Hemagglutinin)
4.	Antiviral Agents (Antivirals)
5.	Antibodies
6.	peramivir
7.	N-Acetylneuraminic Acid (Sialic Acid)
8.	Vaccines
9.	Amantadine (Aman)
10.	Rimantadine

Related Therapies and Procedures

1.	Chemoprevention
2.	Drug Therapy (Chemotherapy)
3.	Long-Term Care
4.	Home Nursing (Nursing, Home)
5.	Mucosal Administration