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Acyclovir (Aciclovir)

A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.

Also Known As:

Aciclovir; Zovirax; 9-((2-Hydroxyethoxy)methyl)guanine; Abello Brand of Aciclovir; Aci-Sanorania; Acic; Aciclobeta; Aciclostad; Aciclovir Alonga; Aciclovir-Sanorania; Acifur; Acipen Solutab; Acivir; Activir; Acyclo-V; Acyclovir Sodium; Alcon Brand of Aciclovir; Alonga Brand of Aciclovir; Alonga Brand of Aciclovir Sodium Salt; Alphapharm Brand of Aciclovir; Amrad Brand of Aciclovir; Antiherpes Creme; Avirax; Azupharma Brand of Aciclovir; Betapharm Brand of Aciclovir; Britisfarma Brand of Aciclovir; Britisfarma Brand of Aciclovir Sodium Salt; Bull Brand of Aciclovir; Cicloferon; Clonmel Brand of Aciclovir; Clonorax; Cusiviral; Dermapharm Brand of Aciclovir; Fabrigen Brand of Aciclovir; Fustery Brand of Aciclovir; Genvir; Glaxo Wellcome Brand of Aciclovir; Glaxo Wellcome Brand of Aciclovir Sodium Salt; Grin Brand of Aciclovir; Grünenthal Brand of Aciclovir; Grünenthal Brand of Aciclovir Sodium Salt; Herpetad; Herpofug; Herpotern; Herpoviric; Hexal Brand of Aciclovir; Hexal Brand of Aciclovir Sodium Salt; Isavir; Isis Brand of Aciclovir; Kendrick Brand of Aciclovir; Laciken; Lichtenstein Brand of Aciclovir; Liomont Brand of Aciclovir; Mann Brand of Aciclovir; Mapox; Maynar; Menarini Brand of Aciclovir; Menarini Brand of Aciclovir Sodium Salt; Milavir; Niddapharm Brand of Aciclovir; Novag Brand of Aciclovir; Novartis Brand of Aciclovir; Opthavir; Parke Davis Brand of Aciclovir; Pensa Brand of Aciclovir; Pensa Brand of Aciclovir Sodium Salt; Pharma Investi Brand of Aciclovir; Pisa Brand of Aciclovir; Rentschler Brand of Aciclovir; Rentschler Brand of Aciclovir Sodium Salt; Sanorania Brand of Aciclovir; Sanorania Brand of Aciclovir Sodium Salt; Stada Brand of Aciclovir; Supraviran; TAD Brand of Aciclovir; Ursapharm Brand of Aciclovir; Viclovir; Vipral; Virax-Puren; Virherpes; Virmen; Virolex; Virupos; Virzin; Warner Wellcome Brand of Aciclovir; Warner-Lambert Brand of Aciclovir; Wellcome Brand of Aciclovir; Wellcome Brand of Aciclovir Sodium Salt; Wellcome-248U; Wolff Brand of Aciclovir; Yamanouchi Brand of Aciclovir; Zoliparin; Zovirax for Injection; Zyclir; Zyma Brand of Aciclovir; aciclovir von ct; ct-Arzneimittel Brand of Aciclovir; curasan Brand of Aciclovir Sodium Salt; Aci Sanorania; Aciclovir Abello Brand

Networked: 3596 relevant articles (558 outcomes, 510 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Purines: 436
    - Purinones
      - Hypoxanthines: 1
        Guanine: 1530
        Acyclovir: 3596
        Ganciclovir: 2944
        valacyclovir: 492
        penciclovir: 97
        desciclovir: 8
        9-(3,4-dihydroxybutyl)guanine: 4
        acyclovir monophosphate: 3
        acyclovir triphosphate: 3
        1-O-hexadecylpropanediol-3-p-acyclovir: 2
        val-valacyclovir: 2
        1-O-hexadecylpropanediol-3-phosphoacyclovir: 1
        1-O-octadecyl-sn-glycero-3-phospho-acyclovir: 1
        2,6-diamino-9-(2-hydroxyethoxymethyl)purine: 1
        9-(2'-(9''-octadecenoyloxy)ethoxymethyl)guanine: 1
        acyclovir diphosphate dimyristoylglycerol: 1
        bucyclovir triphosphate: 1
        penciclovir triphosphate: 1
        2'-O-glycyl acyclovir
        3,9-dihydro-3-((2-hydroxyethoxy)methyl)-6-ethyl-9-oxo-5H-imidazo(1,2-a)purine
        3-methyl-cyclosal-PCVMP
        6-deoxypenciclovir
        8-fluoropenciclovir
        9-((1,3-dihydroxy-2-propylthio)methyl)guanine
        9-((2-aminoethoxy)methyl)guanine
        9-(4-hydroxy-2-(hydroxymethyl)butyl)-guanine triphosphate
        9-(4-hydroxybutyl)guanine
        acycloguanosine H-phosphonate
        acyclovir beta-glucoside
        acyclovir fluorophosphate
        acyclovir monophosphate-lactosaminated serum albumin conjugate
        acyclovir phosphite
        acyclovir-5'-(phenyl methoxy alaninyl)phosphate
        BIOLF 143
        bis(2-(guanin-9-ylmethoxy)ethoxy)-4-(methylsulfonyl)phenyl phosphate
        BRL 42359
        diamminechloro(9-(2-hydroxyethoxymethyl)guan-7-yl)platinum(II)
        gamma-glutamylacyclovir
        guanin-9-yl methyloxy-2-ethyl bis(S-acetyl-2-thioethyl) phosphate
        guanin-9-yl methyloxy-2-ethyl bis(S-pivaloyl-2-thioethyl) phosphate
        tyrosylacyclovir

Experts

1.	Wald, Anna: 20 articles (02/2015 - 04/2002)
2.	Corey, Lawrence: 14 articles (06/2013 - 04/2002)
3.	Celum, Connie: 12 articles (02/2013 - 08/2006)
4.	De Clercq, Erik: 10 articles (11/2013 - 02/2002)
5.	Shiraki, Kimiyasu: 9 articles (06/2015 - 05/2002)
6.	De Clercq, E: 9 articles (06/2007 - 08/2000)
7.	Whitley, Richard J: 8 articles (12/2015 - 02/2002)
8.	Saijo, Masayuki: 7 articles (01/2014 - 03/2002)
9.	Mitra, Ashim K: 7 articles (08/2013 - 06/2003)
10.	Galegov, G A: 7 articles (01/2013 - 01/2000)

Related Diseases

1.	Infection 01/01/1999 - "The efficacy of aciclovir for treatment of primary and recurrent VZV infections in children has reduced the morbidity and mortality of these illnesses in immunocompromised children dramatically. " 05/01/1993 - "Acyclovir was found to be the most useful first-line treatment, with 55% of patients deriving benefit from either continuous oral acyclovir or a patient-initiated 5-day oral course at the onset of herpes simplex virus infection. " 12/27/1985 - "The protection against active infection with HSV during the period of prophylaxis with acyclovir is statistically highly significant. " 06/01/1985 - "Oral acyclovir is highly effective for the treatment of recurrent mucocutaneous infections caused by herpes simplex virus in immunocompromised patients." 04/01/1979 - "Systemic treatment of mice with the nucleoside analog 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine [aciclovir]) was found to be highly effective against acute type 1 herpes simplex virus infection of the pinna. "
2.	Herpes Zoster 10/15/1989 - "Regarding the treatment of herpes zoster, aciclovir (ACV) is as the most effective and safe drug available. " 06/16/1983 - "Acyclovir recipients with disseminated cutaneous zoster had a significantly accelerated rate of clearance of virus from vesicles, as compared with placebo recipients (P = 0.05 by the Breslow test)." 08/29/1988 - "In summary, oral acyclovir at a dosage of 800 mg five times per day for 10 days for treatment of acute herpes zoster is superior to 400 mg five times per day and favorably alters the course of the disease." 06/01/1997 - "Oral acyclovir is a costly antiviral agent shown to be effective in the treatment of herpes zoster. " 04/01/1989 - "Acyclovir was found to be effective to treat herpes zoster in these patients. "
3.	Herpes Genitalis (Genital Herpes) 08/01/1991 - "There is good evidence that early treatment with systemic Acyclovir is effective in patients with a first attack of genital herpes. " 07/01/1994 - "Continuous infusion of acyclovir is more effective than discontinuous infusion for treatment of genital herpes in an immunocompromised patient." 08/29/1988 - "Daily administration of oral acyclovir for one year is superior to intermittent or placebo treatment in the management of patients with frequently recurring genital herpes." 11/01/1983 - "Topical therapy with 10% araA-2',3'-diacetate, initiated at 24 h postinfection, was as effective as, if not more effective than, acyclovir in reducing the severity of herpes genitalis in guinea pigs. " 12/01/2003 - "Acyclovir prophylaxis beginning at 36 weeks' gestation was effective in reducing clinical HSV recurrences at the time of delivery (OR 0.25; 95% confidence interval [95% CI] 0.15, 0.40), cesarean deliveries for clinical recurrence genital herpes (OR 0.30; 95% CI 0.13, 0.67), total HSV detection at delivery (OR 0.11; 95% CI 0.04, 0.31), and asymptomatic HSV shedding at delivery (OR 0.09; 95% CI 0.02, 0.39). "
4.	Chickenpox 03/01/1998 - "In our study application of acyclovir in that age group provided good results as for prevention and treatment of complications of chickenpox if already manifested." 01/01/2007 - "The patient with chickenpox was treated successfully with acyclovir without complication. " 03/01/1995 - "We conclude that early treatment with acyclovir was beneficial whereas late therapy had limited effect in reducing the severity of cutaneous lesions in patients with varicella." 01/01/1988 - "Intravenous acyclovir is effective for varicella in adults and immunocompromised children, causing more rapid resolution of the illness and fewer complications. " 02/01/1994 - "Overall this formulation of aciclovir appears to be a safe and effective treatment for chickenpox in this patient population. "
5.	Herpes Simplex 03/01/2005 - "Improved neurodevelopmental outcomes following long-term high-dose oral acyclovir therapy in infants with central nervous system and disseminated herpes simplex disease." 07/01/2003 - "Acyclovir (ACY) is effective in the treatment of herpes simplex (HSV-1) & (HSV-2) but has systemic toxic effects if given orally or intravenously. " 01/01/1994 - " Acyclovir is effective against Herpes simplex. " 01/07/1988 - "[Acyclovir--the first clinically useful peroral agent effective in herpes simplex]." 06/19/2011 - "Meta-analysis of randomized trials on the association of prophylactic acyclovir and HIV-1 viral load in individuals coinfected with herpes simplex virus-2."

Related Drugs and Biologics

1.	valacyclovir (valaciclovir)
2.	Acyclovir (Aciclovir)
3.	Vidarabine (Vira-A)
4.	Foscarnet
5.	Ganciclovir (Cytovene)
6.	famciclovir (Famvir)
7.	Antiviral Agents (Antivirals)
8.	Prednisolone (Predate)
9.	cidofovir (Vistide)
10.	penciclovir (Denavir)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Transplants (Transplant)
3.	Oral Administration
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
5.	Drug Therapy (Chemotherapy)