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Nelfinavir (Viracept)

A potent HIV protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children.

Also Known As:

Viracept; Nelfinavir Mesylate; AG 1343; AG-1343; AG1343; Agouron Brand of Nelfinavir Mesylate; Nelfinavir Monomethane Sulfonate; Roche Brand of Nelfinavir Mesylate; Mesylate, Nelfinavir; Monomethane Sulfonate, Nelfinavir; Sulfonate, Nelfinavir Monomethane

Networked: 302 relevant articles (17 outcomes, 67 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 60
- 2-Ring Heterocyclic Compounds
  - Isoquinolines: 16
    - Nelfinavir: 302

Experts

1.	Brüning, Ansgar: 10 articles (12/2013 - 12/2008)
2.	Friese, Klaus: 7 articles (12/2013 - 12/2008)
3.	Maity, Amit: 5 articles (05/2015 - 09/2006)
4.	Chow, Warren A: 5 articles (01/2015 - 09/2006)
5.	Hahn, Stephen M: 5 articles (01/2014 - 09/2006)
6.	Rahmeh, Martina: 5 articles (12/2013 - 12/2008)
7.	Schönthal, Axel H: 5 articles (12/2012 - 11/2007)
8.	Chen, Thomas C: 5 articles (12/2012 - 01/2007)
9.	Guan, Min: 4 articles (01/2015 - 04/2011)
10.	Dennis, Phillip A: 4 articles (09/2014 - 09/2007)

Related Diseases

1.	HIV Infections (HIV Infection) 09/01/2013 - "Nelfinavir is being studied for the prevention and treatment of a wide range of malignancies in persons with and without HIV infection. " 04/01/2006 - "A review of nelfinavir for the treatment of HIV infection." 01/01/2005 - "Nelfinavir also has a role in the management of pregnant patients as well as paediatric patients with HIV infection." 01/01/2005 - "Nelfinavir may be used in the treatment of adults, adolescents and children aged >or=2 years with HIV infection. " 01/01/2005 - "Nelfinavir: a review of its use in the management of HIV infection."
2.	Ovarian Neoplasms (Ovarian Cancer) 10/01/2010 - "We have previously demonstrated induction of apoptosis by nelfinavir even in chemo-resistant ovarian cancer cells. " 02/01/2009 - "Nelfinavir induces the unfolded protein response in ovarian cancer cells, resulting in ER vacuolization, cell cycle retardation and apoptosis." 12/26/2008 - "We conclude that nelfinavir, an already approved drug, is a highly efficient agent against ovarian cancer cells and could sensitize ovarian cancer cells to TRAIL treatment, either therapeutically applied or endogenously produced by cells of the immune system." 12/26/2008 - "In vitro, at concentrations used to induce cell death in ovarian cancer cells, nelfinavir had no effect on the cellular viability of fibroblasts or peripheral blood mononuclear leukocytes. " 12/26/2008 - "Nelfinavir induces TRAIL receptor upregulation in ovarian cancer cells."
3.	Malaria 06/01/2010 - "Furthermore, anti-microbial effects of nelfinavir have been described, including an efficacy against malaria, tuberculosis, and SARS. " 05/01/2015 - "The HIV protease inhibitor, nelfinavir, primarily used for the treatment of HIV infections, has later been shown to be effective in various infectious diseases including malaria. " 01/01/2010 - "HIV protease inhibitors, indinavir or nelfinavir, are important antiretroviral drugs and artemisinin is central to malaria treatment. "
4.	Acquired Immunodeficiency Syndrome (AIDS) 10/01/2005 - "Efficacy, tolerability and pharmacokinetics of two nelfinavir-based regimens in human immunodeficiency virus-infected children and adolescents: pediatric AIDS clinical trials group protocol 403." 09/01/2003 - "Nelfinavir pharmacokinetics in stable human immunodeficiency virus-positive children: Pediatric AIDS Clinical Trials Group Protocol 377." 11/01/2015 - "Nelfinavir mesylate (NFV) is an anti-viral drug, used in the treatment of Acquired Immunodeficiency Syndrome (AIDS). " 07/01/2010 - "HIV-1-infected children (n = 152) from Pediatric AIDS Clinical Trial Group 366 or 377 receiving nelfinavir as a component of HAART were evaluated. " 12/01/2005 - "Adult AIDS Clinical Trials Group study 384 randomized antiretroviral-naive subjects to receive efavirenz and/or nelfinavir plus 2 nucleoside analogues, with follow-up lasting up to 3 years. "
5.	Infection 06/04/2004 - "Experiments with various timings of drug addition revealed that nelfinavir exerted its effect not at the entry step, but at the post-entry step of SARS-CoV infection. " 06/04/2004 - "Nelfinavir inhibited the cytopathic effect induced by SARS-CoV infection. " 01/01/1996 - "AG1343 has potent antiviral activity (95% effective dose = 0.04 microgram/ml) against a number of HIV-1 strains in acute and chronic models of infection. " 09/01/2013 - "Cycloviolacin O2 (CyO2) suppresses productive infection and augments the antiviral efficacy of nelfinavir in HIV-1 infected monocytic cells." 07/24/2002 - "Effect of antiretroviral triple combinations including the protease inhibitor nelfinavir in heavily pretreated children with HIV-1 infection."

Related Drugs and Biologics

1.	Ritonavir (Norvir)
2.	Indinavir (Crixivan)
3.	Saquinavir (Invirase)
4.	lopinavir (Kaletra)
5.	Protease Inhibitors (Protease Inhibitor)
6.	HIV Protease Inhibitors
7.	sorafenib (BAY 43-9006)
8.	Reverse Transcriptase Inhibitors
9.	amprenavir (141W94)
10.	atazanavir (Reyataz)

Related Therapies and Procedures

1.	Highly Active Antiretroviral Therapy (HAART)
2.	Radiotherapy
3.	Heterologous Transplantation (Xenotransplantation)
4.	Castration
5.	Salvage Therapy