Antiviral Agents (Antivirals)

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

Also Known As:

Networked: 3949 relevant articles (410 outcomes, 339 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	De Clercq, Erik: 25 articles (11/2015 - 08/2002)
2.	Neyts, Johan: 18 articles (12/2015 - 08/2002)
3.	Hayden, Frederick G: 14 articles (03/2015 - 01/2004)
4.	Zeuzem, Stefan: 13 articles (07/2015 - 04/2007)
5.	Soriano, Vincent: 13 articles (03/2015 - 04/2006)
6.	Hurt, Aeron C: 13 articles (01/2015 - 06/2007)
7.	Smee, Donald F: 13 articles (01/2015 - 07/2002)
8.	Marcellin, Patrick: 12 articles (07/2015 - 10/2006)
9.	Barreiro, Pablo: 12 articles (03/2015 - 05/2008)
10.	Monto, Arnold S: 12 articles (12/2014 - 05/2003)

Related Diseases

1.	Infection 07/01/2015 - "We are entering a new era in the treatment of hepatitis C virus (HCV) infection and almost all patient groups in high-income countries have the potential to be cured with all-oral, highly potent combinations of direct-acting antiviral drugs. " 05/01/2010 - "Both TAP and STAP interventions were highly effective in suppressing the spread of infection during the early period of an outbreak, but STAP was inferior to TAP in terms of the ripple effect of the administration of antiviral drugs. " 09/01/2000 - "The successful development of effective antivirals to treat the most common external ocular viral infections have dramatically reduced morbidity and sight loss. " 01/01/1997 - "Early diagnosis and treatment of cytomegalovirus (CMV) infection with new antiviral drugs have dramatically reduced the incidence and mortality in CMV disease. " 02/01/2007 - "Optimal virological studies of blood, cerebrospinal fluid and affected tissue for confirmation of diagnosis are discussed; this is particularly important because some HHV infections of the nervous system can be treated successfully with antiviral agents."
2.	Human Influenza (Influenza) 01/01/2015 - "The ferret is a suitable small animal model for preclinical evaluation of efficacy of antiviral drugs against various influenza strains, including highly pathogenic H5N1 viruses. " 12/01/2014 - "Indeed, although vaccination is the most powerful means of mitigating the effects of influenza epidemics, antiviral drugs can be very useful, particularly in delaying the spread of new pandemic viruses, thereby enabling manufacturers to prepare large quantities of pandemic vaccine. " 11/01/2013 - "The goals of the meeting were to improve pandemic planning in the region from lessons learned during the 2009 pandemic, particularly with regard to the safety and efficacy of antiviral use; gain a better understanding of the therapeutic use of antivirals in seasonal influenza; review and analyse the official influenza control policies of Asia-Pacific countries and evidence gaps to support policy development; and to establish collaborative relationships to promote best practices in the use of antivirals for the treatment of influenza. " 02/04/2013 - "These promising results demonstrate that the oral peptide transporter-mediated prodrug strategy has enormous promise for improving the oral mucosal cell membrane permeability of polar, poorly absorbed antiviral agents and treating influenza via the oral route of administration." 06/01/2007 - "The availability of isolation facilities, the stockpiling of antiviral agents and effective and safe vaccination will be extremely important in minimising the damage of a new influenza pandemic."
3.	Hepatitis C 10/28/2013 - "Step by step the efficacy of the therapy for hepatitis C is rapidly increasing and nowadays with the very new medications, the so called Direct Antiviral Agents-DAAs of new generation, is around 80%-90%." 01/01/2015 - "Within the past years, direct-acting antivirals (DAAs) have had a major impact on the management of chronic hepatitis C, which has become a curable disease in the majority of DAA-treated patients. " 10/01/2015 - "The presence of resistance-associated variants (RAV) may attenuate the efficacy of direct-acting antivirals (DAA) in combination therapy for hepatitis C. " 03/01/2015 - "IFN-free regimens with direct antiviral agents (DAAs) against hepatitis C virus (HCV) are likely to greatly expand patients' access and response to hepatitis C therapy, while safety and tolerability of treatments seem substantially improved. " 06/01/2014 - "To increase efficacy of hepatitis C treatment, future regiments will incorporate multiple direct-acting antiviral drugs. "
4.	Hepatitis B 01/01/2013 - "[Management of chronic hepatitis B: effective antiviral agents are available, but what now?]." 06/01/2007 - "Clinical management of chronic hepatitis B is rapidly evolving after the recent development of new antiviral drugs. " 11/01/2003 - "The long-term outcome of hepatitis B patients is poor and the efficacy of antiviral drugs needs further study." 01/01/2003 - "Although antiviral agents have been adopted for the management of chronic hepatitis B, they have only limited efficacy because of the underlying impaired immune status. " 01/01/2012 - "The development and evaluation of antiviral agents through carefully designed clinical trials over the last 25 years have heralded a new dawn in the treatment of patients chronically infected with the hepatitis B and C viruses, but not so for the D virus (HBV, HCV, and HDV). "
5.	Chronic Hepatitis B 12/01/2014 - "Recently, there have been remarkable improvement in the treatment of chronic hepatitis B (CHB) using potent antiviral agents. " 05/27/2014 - "Treatment of chronic hepatitis B (CHB) has markedly improved in the last 15 years due to the availability of direct antivirals which greatly increase therapeutic options. " 10/01/2011 - "Treatment for chronic hepatitis B (CHB) has improved over the last 10 years mainly due to the development of effective oral antiviral agents [nucleoside/nucleotide analogs (NUCs)]. " 11/01/2003 - "To clarify the natural history of chronic hepatitis B so as to evaluate its long-term therapeutic outcome of the patients and the efficacy of antiviral drugs. " 10/01/2009 - "Diagnosis and treatment of chronic hepatitis B (CHB) have improved in recent years with introduction of new oral antiviral drugs. "

Related Drugs and Biologics

1.	Interferons
2.	Vaccines
3.	Ribavirin (Virazole)
4.	Neuraminidase (Sialidase)
5.	Acyclovir (Aciclovir)
6.	Amantadine (Aman)
7.	Rimantadine
8.	Lamivudine (3TC)
9.	Zanamivir (Relenza)
10.	Interferon-alpha (Interferon Alfa)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Transplants (Transplant)
3.	Therapeutics
4.	Plasma Exchange
5.	Immunotherapy