Ganciclovir (Cytovene)

An ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.

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Networked: 2944 relevant articles (455 outcomes, 338 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Humar, Atul: 11 articles (01/2015 - 04/2004)
2.	Ylä-Herttuala, Seppo: 10 articles (01/2015 - 04/2002)
3.	Michel, Detlef: 9 articles (01/2013 - 02/2002)
4.	Lautenschlager, Irmeli: 8 articles (10/2015 - 08/2002)
5.	Baldanti, Fausto: 8 articles (02/2015 - 04/2002)
6.	Boeckh, Michael: 8 articles (01/2015 - 01/2002)
7.	Namba, Hiroki: 8 articles (11/2012 - 01/2005)
8.	Razonable, Raymund R: 8 articles (09/2010 - 04/2002)
9.	Wahlfors, Jarmo: 8 articles (06/2006 - 04/2003)
10.	Paya, Carlos V: 8 articles (10/2005 - 04/2002)

Related Diseases

1.	Infection 12/01/2014 - "Ganciclovir (GCV) has dramatically reduced complications caused by CMV infections. " 12/01/2004 - "Oral treatment with 45 or 15 mg of CPV/kg initiated 24 h after infection was highly effective in reducing replication to undetectable levels in both models and was generally more effective than ganciclovir. " 01/01/1995 - "Currently, ganciclovir is the most safe and effective agent for the treatment of CMV infection. " 04/20/1997 - "Ganciclovir is being tested in clinical trials as a treatment for congenital CMV infection, and was given to two of our patients with apparently good results." 03/01/2012 - "Ganciclovir is beneficial for the treatment of congenital cytomegalovirus (CMV) infections involving the central nervous system (CNS). "
2.	Retinitis 01/01/2001 - "Ganciclovir (GCV) implants are highly effective in delaying the progression of cytomegalovirus (CMV) retinitis. " 12/01/1989 - "Ganciclovir appears to be a promising therapy for CMV retinitis, but further work is necessary to determine the best regimen for optimal efficacy with minimal side effects." 06/01/2008 - "Four months after presentation, gancyclovir was intravitreously injected a total of 5 times, and the retinitis resolved completely. " 07/01/2005 - "The retinitis resolved completely with systemic ganciclovir. " 09/01/2014 - "Non-HIV patients with CMV retinitis can be successfully treated with intravitreal ganciclovir injection alone, avoiding the systemic side effects of systemic anti-CMV therapy."
3.	Neoplasms (Cancer) 11/15/2007 - "Further studies revealed that normal brain cells transduced with VSV-G pseudotypes were not eliminated by ganciclovir treatment and contributed significantly to the bystander killing of tumor cells. " 01/01/1999 - "Rats were then treated with injection of gancyclovir and we observed significant reduction in tumor growth and an increase in survival for the treated rats as compared to control animals (injected with the corresponding buffer). " 04/15/1998 - "All animals receiving tk and ganciclovir demonstrated tumor regression, however a significantly greater response was seen in mice that were treated with both tk + mIL-2. " 11/01/1997 - "Ganciclovir treatment of animals injected with DHD/K12-TK cells allowed a significant reduction of the tumor volume as well as a prolonged survival. " 07/01/2008 - "Mice bearing SCC-7-induced tumors received cytoreduction followed by Ad-HSV-UTk + ganciclovir (GCV) or control treatment and were followed for disease-free and overall survival. "
4.	Acquired Immunodeficiency Syndrome (AIDS) 01/01/2014 - "We present the case of a 31-year-old man with AIDS and diagnosis of PEL, in whom sustained and complete remission of the tumour was achieved with adjunctive ganciclovir therapy. " 12/01/1989 - "This study supports the conclusions of previous uncontrolled studies that ganciclovir is beneficial in the treatment of patients with acquired immunodeficiency syndrome and cytomegalovirus retinopathy. " 08/01/2000 - "The BIE results for the ganciclovir prophylaxis arm, in contrast, showed a significant reduction of 27% in hospital cost among hospital users, and 44% among the total sample of AIDS patients. " 04/01/2013 - "Intravitreal ganciclovir is an effective treatment of CMVR in adult acquired immunodeficiency syndrome (AIDS) patients. " 07/01/1987 - "By reducing or delaying visual loss, ganciclovir appears to be useful in the management of CMV retinopathy in patients with AIDS."
5.	Cytomegalovirus Infections (Inclusion Disease) 08/01/1999 - "Ganciclovir is a nucleoside analogue with an excellent safety record; it is effective against cytomegalovirus infection in both its intravenous and its oral form. " 01/01/1999 - "The antiviral nucleoside analogue ganciclovir is a potent inhibitor of replication in herpes viruses and is effective against cytomegalovirus infections in immunocompromised patients. " 04/01/1995 - "The first patient showed marked improvement in pulmonary symptoms resulting from cytomegalovirus infection by means of gancyclovir treatment. " 11/01/1991 - "The safety and efficacy of a 10-day course of ganciclovir therapy was assessed in 17 consecutive patients with proven cytomegalovirus infection. " 11/01/1993 - "Cytomegalovirus infections were treated successfully with ganciclovir in 11 patients. "

Related Drugs and Biologics

1.	Thymidine Kinase
2.	Foscarnet
3.	valganciclovir
4.	Acyclovir (Aciclovir)
5.	cidofovir (Vistide)
6.	DNA (Deoxyribonucleic Acid)
7.	valacyclovir (valaciclovir)
8.	Liposomes (Liposome)
9.	Antiviral Agents (Antivirals)
10.	Immunoglobulins (Immunoglobulin)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Transplantation (Transplant Recipients)
3.	Intravitreal Injections
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
5.	Drug Therapy (Chemotherapy)