Virus Diseases (Viral Diseases)

07/01/2004 - "The present paper provides a review of the vaccines being employed today against the most important equine viral diseases followed by a summary of new developments that are expected to bring improved vaccines to the market in the foreseeable future."
10/01/2000 - "While these have been extremely effective for prevention against viral diseases, development of vaccines against rapidly changing pathogens such as human immunodeficiency virus (HIV) and hepatitis C virus has proved to be more difficult. "
01/01/1993 - "Successful field oral vaccination and protection against viral diseases have so far been achieved only with live-attenuated or live-recombinant virus vaccines. "
06/01/1997 - "Viral diseases are untreatable and because effective and safe vaccines for fish are not yet commercially available, a great care needs to be exercised when moving fish or eggs from one site or country to another. "
01/01/2010 - "BAC-based mutagenesis strategies of viruses can advance our understanding of the viral gene functions and determinants of pathogenicity, and can ultimately help to develop molecularly defined improved vaccines against virus diseases. "

05/14/1983 - "When used in the treatment of viral disease, interferon has shown itself to be quite effective in reducing viral titres. "
03/01/1998 - "The efficacy of interferons alpha is now also being evaluated in other malignancies and virus diseases. "
05/01/1991 - "The efficacy of human leukocytic interferon (ointment), 20000 IU/g, in the treatment of viral diseases of the buccal mucosa was studied in 152 patients. "
09/01/1992 - "Future studies will seek to optimize the therapeutic effects of interferon in these viral diseases. "
01/01/1983 - "Studies in experimental animals and in man have indicated that administration of exogenous interferon can prevent viral disease if the interferon reaches the crucial sites of viral replication in sufficient concentration and before the virus replication starts. "

01/01/1985 - "Finally, a better understanding of the pathogenesis and the natural course of viral diseases will contribute to the development of more effective and safe antiviral agents."
06/01/2010 - "Due to the effectiveness of the vaccine, antiviral development solely for the treatment of YFV is not feasible, but antivirals that are effective in the treatment of related viral diseases may be characterized for potential use against YFV as a secondary indication disease. "
07/01/2004 - "Advances in molecular biology and popular demand to develop antiviral agents for viral diseases (eg, human immunodeficiency virus) offer great promise for the future."
11/12/2015 - "Clinical trials have demonstrated that, for the first time in human history, the potential exists to eradicate a chronic viral disease using combination therapies that contain only direct-acting antiviral agents. "
06/01/1985 - "Combinations of antiviral agents synergistic in cell cultures should be pursued with further studies in animal models of human viral disease and potentially in clinical trials."

01/01/2014 - "An improved understanding of the fundamental mechanisms of how DCs recognize HSV, process and present its antigens to naïve and effector T cells will not only assist in the improvement of vaccine-based preventions of this important viral disease, but also serves as a paradigm to resolve basic immunological principles. "
02/01/1998 - "To our knowledge, this is the first study showing protection against a viral disease by immunization with an antigen expressed in a transgenic plant."
07/01/2006 - "In this study, we describe the expression of one of the target antigens, 380R, from the red sea bream iridovirus (RSIV), which is one of the most common viral diseases in the cultured marine fish Pagrus major in Japan, using the arming yeast system and aiming at its application for oral vaccination. "
10/05/1991 - "Study of secretor status in patients with respiratory virus diseases determined by an enzyme linked immunosorbent assay (ELISA) developed to identify Lewis (Le) blood group antigen phenotypes (Le(a) non-secretor; Le(b) secretor). "
05/01/2014 - "Genes coding for human leukocyte antigen (HLA) class II molecules are polymorphic and have been shown to influence susceptibility to viral diseases. "

05/01/2003 - "We conclude that ribavirin potentiates virus-induced ISRE signaling to enhance the expression of antiviral ISGs, suggesting a mechanism for the efficacy of combined treatment with ribavirin and IFN in other chronic viral diseases."
02/01/2011 - "Although antiviral efficacies of both compounds against IHNV and IPNV were lower than those of ribavirin used as a positive control, our findings suggested that the red alga Polysiphonia morrowii and isolated two bromophenols may have potential as a therapeutic agent against fish viral diseases."
03/01/2010 - "Ribavirin delayed death from viral disease in NiV-infected hamsters by approximately 5 days, but no significant effect in HeV-infected hamsters was observed. "
05/01/2000 - "The demonstrated utility of the nucleoside analog ribavirin in the treatment of certain viral diseases can be ascribed to its multiple distinct properties. "
04/01/2014 - "Ribavirin is widely used in the treatment for viral disease such as chronic viral hepatitis. "

12/01/2013 - "DNA vaccines have been particularly successful against the Novirhabdoviruses while there are reports on the efficacy against viral pathogens like infectious pancreatic necrosis virus, infectious salmon anemia virus, and lymphocystis disease virus and these are inferior to what has been attained for the novirhabdoviruses. "
09/01/2005 - "The efficacy of DNA vaccines in animal models is highlighted, especially in viral diseases against which no widely accepted vaccination is currently available. "
12/01/2013 - "DNA vaccines against viral diseases of farmed fish."
08/14/2006 - "Our results have implications in the development of DNA vaccines against avian viral diseases by bacteria-vectored oral delivery system."
01/01/2000 - "A significant number of articles published in the field of DNA vaccines are dealing with viral diseases, reflecting the need for better and alternative vaccination strategies against viruses. "

11/07/2007 - "Although vaccination could not provide complete clinical or virological protection, it reduced the severity of the disease, virus excretion and production of non-structural FMDV antibodies in vaccinated and subsequently infected pigs. "
07/01/2006 - "Several studies have been reported on using detection of serum antibodies against flavivirus for the diagnosis of specific flaviviral disease; no field-based pan-flavi virus detection system is available, which can be used in low-endemicity areas for differentiation of flaviviral disease from other viral diseases. "
07/14/2015 - "Here we demonstrate the use of the VelocImmune technology (a mouse that expresses human antibody-variable heavy chains and κ light chains) alongside the VelociGene technology (which allows for rapid engineering of the mouse genome) to quickly develop and evaluate antibodies against an emerging viral disease. "
01/01/2014 - "In recent years, several new ELISAs for the detection of antibodies against the porcine reproductive and respiratory disease virus (PRRSV) in pig serum have been developed. "
01/01/2014 - "[Serological survey of antibodies against viral diseases of public health interest in llamas (Lama glama) from Jujuy province, Argentina]."

09/01/2002 - "Neutralizing antibodies are crucial for vaccine-mediated protection against viral diseases. "
03/15/2013 - "Neutralizing antibodies play an essential part in antiviral immunity and are instrumental in preventing or modulating viral diseases. "
06/11/2009 - "Zika virus disease was confirmed by a finding of Zika virus RNA or a specific neutralizing antibody response to Zika virus in the serum. "
01/15/2014 - "The infected monkeys showed clinical signs of disease, virus replication, histological lesions, and neutralizing antibody production, indicating that this monkey model is suitable for studies of MERS-CoV infection. "
01/01/1980 - "[Serological studies of the dissemination of neutralizing antibodies against the mucosal disease-viral diarrhea virus in cattle]."

06/01/1987 - "For most viral diseases, advances have been made in improved rapid virus isolation techniques, better and more widely available immunofluorescence, and immunoenzyme microscopic techniques, with much of the improvement provided by monoclonal antibodies. "
11/01/1995 - "Anti-respiratory syncytial virus monoclonal antibodies show promise in the treatment and prophylaxis of viral disease."
10/01/2015 - "Monoclonal antibodies (mAbs) are increasingly being considered as agents to fight severe viral diseases. "
01/01/2009 - "Interest in the potential of monoclonal antibodies (mAbs) to serve as therapeutic agents has surged in the past decade with a major emphasis on human viral diseases. "
01/01/2007 - "Monoclonal antibodies (mAbs) developed for either the prevention or treatment of viral diseases represent a small, but valuable, class of products. "

09/24/1986 - "These procedures permit efficient and reproducible screening of both endogenous and exogenous (viral) gene products, thus facilitating the study of normal differentiation, the localization of virus and the monitoring of viral diseases. "
04/01/2014 - "Viral proteins have enabled the design of selective and efficacious treatments for viral diseases. "
01/01/2011 - "Detection of viral proteins in combination with viral transcripts is a potentially powerful method for establishing virus-disease relationships."
09/01/2009 - "It was interesting whether Abs from patients with viral diseases can hydrolyze viral proteins. "
07/20/2001 - "The highest homologies were detected between putative viral gene products of CIV and lymphocystis disease virus of fish (LCDV). "

08/01/2009 - "Taken together, our findings indicate that non-specific immunotherapy with P-MAPA appears to be an effective treatment for blocking Punta Toro virus-induced disease and suggest that further exploration with other viral disease models is warranted."
03/01/2006 - "Taken together, our findings indicate that non-specific immunotherapy with CLDC appears to be an effective treatment for blocking PTV-induced disease and suggests that further exploration in other viral disease models may be warranted."
04/01/2009 - "Cytotoxic CD8(+) T cells are key effectors in the immunotherapy of malignant and viral diseases. "
11/18/2008 - "Cytotoxic CD8(+) T cells are key effectors in the immunotherapy of malignant and viral diseases. "
11/15/2003 - "Cytotoxic CD8 T cells are key effectors in the immunotherapy of malignant and viral diseases. "

08/01/2010 - "Conventional treatment of severe viral disease is limited by the narrow choice as well as the often-significant side effects or lack of clear efficacy of antiviral chemotherapy. "
10/01/2002 - "Drug discovery for antiviral chemotherapy has provided the effective treatment of numerous viral diseases. "
01/01/1988 - "Clinical trials have been started with a variety of these new compounds and the prospects for an effective chemotherapy of several viral diseases certainly look bright."
05/01/2005 - "This antibody deficiency may place children with ALL at risk for the development of these bacterial and viral diseases, even after completion of chemotherapy. "
01/15/2003 - "In chemotherapy to treat human immunodeficiency virus (HIV) and other viral diseases, resistance has become a major problem. "

04/01/2011 - "Over the course of several months, cutaneous manifestations of viral disease resolved completely and both patients remain clinically well and free of infectious complications at 4 and 2 years, respectively, after transplantation. "
10/01/2003 - "Additional developments have contributed to improve the results of liver replacement including individualized immunosuppression strategies and novel treatment options to avoid recurrent viral disease following transplantation."
01/01/2013 - "Emerging viral diseases in kidney transplant recipients."
09/01/2012 - "[Prophylaxis against respiratory viral disease in pediatric and adult patients undergoing solid organ and hematopoietic stem cells transplantation]."
08/27/2009 - "Notwithstanding their naive phenotype, it is therefore possible to generate trivirus-specific CTLs in a single culture of CB, which may be of value to prevent or treat viral disease in CB transplant recipients. "

01/01/2013 - "Aptamer-based therapeutics: new approaches to combat human viral diseases."
05/01/2012 - "However, to play a more defining role in prognostics, diagnostics and therapeutics for virus diseases, acknowledged drawbacks, including false positives and negatives, inherent in this technology, must be successfully addressed."
11/09/2009 - "RNA interference-based therapeutics for shrimp viral diseases."
07/01/2005 - "The lack of effective therapeutics for CVB3-caused viral diseases underscores the importance of searching for antiviral compounds. "
01/01/1995 - "Means for discovery of translation-targeted therapeutics for viral disease are discussed."

01/01/2001 - "Disadvantages are the following: the possibility of a transfer of a virus disease which can be eliminated by a careful examination of donors; a longer period of graft remodelling, which can be compensated by a correct physiotherapy and postoperative regime. "
03/01/2013 - "Missed viral surveillance testing visits associate with full blown viral diseases in children receiving kidney transplants."
01/01/2013 - "Viruses acquired from community, such as the respiratory and gastrointestinal viruses, are also important pathogens of post-transplant viral diseases. "
12/01/2011 - "Human cytomegalovirus (HCMV) remains a major cause of viral disease in immunosuppressed transplant patients. "
09/01/2011 - "As the delay in recovery of virus-specific cellular immune response after transplant is associated with viral reactivation and viral disease, adoptive immunotherapy to restore virus-specific cellular immunity is an attractive option. "