Nucleosides

05/23/1998 - "When the ACTG 175 and Delta trials demonstrated the clinical improvement offered by regiments combining 2 nucleosides over monotherapy, combination therapy was being prescribed for less than 20% of all primary infections. "
04/23/2015 - "In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection."
04/01/2015 - "Nucleosides present on phlebotomine saliva induce immunossuppression and promote the infection establishment."
04/01/2015 - "The susceptibility of primate lentiviruses to nucleosides and Vpx during infection of dendritic cells is regulated by CA."
04/01/2013 - "Especially, the non-nucleosides with diverse skeletons and novel mechanism offer prolific candidates for anti-HBV drug discovery, which are preferred to be used as adjuvant therapy for HBV infection. "

01/01/2012 - "Radiolabeled nucleosides for predicting and monitoring the cancer therapeutic efficacy of chemodrugs."
07/08/2015 - "The aim of the study was to elucidate further the usefulness of urinary nucleosides as possible markers at early detection of cancer in persons which are exposed against tumor promoting influences during their working life. "
05/01/2013 - "It has been estimated for diverse rat and mouse hepatocarcinogens that 50-5500 adducts per 10(8) nucleosides are present after repeated treatment at the TD50 (daily dose that halves the probability to stay tumor-free in long-term studies). "
03/29/2013 - "Liquid chromatography tandem mass spectrometry study of urinary nucleosides as potential cancer markers."
02/01/2012 - "In the present study, we investigated the signaling pathways implicated in the induction of apoptosis by two modified nucleosides, 5-phenylselenyl-methyl-2'-deoxyuridine (PhSe-T) and 5-methylselenyl-methyl-2'-deoxyuridine (MeSe-T), using human cancer cell lines. "

10/15/1990 - "The antiviral selectivity of ECP-AZT, defined as the ratio IC50 (virus inhibition)/IC50(cell growth inhibition), was in the range considered to be therapeutic for anti-AIDS nucleosides."
04/01/1990 - "These properties, combined with the previously reported resistance of the fluorinated nucleosides to acid degradation, make these compounds interesting candidates for further study as orally administered agents for the inhibition of human immunodeficiency virus replication in patients with acquired immunodeficiency syndrome."
01/01/2014 - "Conversely to injecting-drug-users and AIDS patients, women and first-treated with non-nucleosides had an excess risk. "
07/01/1996 - "A prospective study was conducted with 161 human immunodeficiency virus (HIV)-positive patients to investigate the prognostic role of 10 serum-modified nucleosides with regard to some of the most widely used parameters of AIDS progression. "
01/01/1990 - "In an AIDS patient, the levels of most of the nucleosides exhibited remarkable increases compared to normal urine."

01/01/1986 - "There are significant differences in the excretion of modified nucleosides between normal individuals and individuals with various forms of leukemia, as well as between leukemia patients at opposite ends of the clinical spectrum, i.e., those with active disease and those in remission. "
01/01/1986 - "Urinary nucleosides offer a number of useful laboratory and clinical applications in the study and analysis of leukemia. "
12/27/2011 - "The deprotected nucleosides were screened against leukemia L-1210 and were found inactive."
03/01/2010 - "The QSAR models for 14 carbocyclic analogues of nucleosides against murine leukemia cell line (L1210/0) and human T-lymphocyte cell lines (Molt4/C8 and CEM/0) explain more than 90% of the variances in the activity data along with higher values of [Formula: see text]. "
10/01/2004 - "The uptake of nucleosides and nucleoside analogs into human leukemia K562 cells is facilitated by the equilibrative transporters ENT1 and ENT2. "

05/01/2005 - "Nucleosides have been widely used in the treatment of viral diseases, but relatively few have been identified as inhibitors of hepatitis C virus (HCV). "
01/01/2003 - "Stealth nucleosides: mode of action and potential use in the treatment of viral diseases."
07/01/2011 - "This novel immobilized biocatalyst has been successfully employed in the enzymatic synthesis of different natural and therapeutic nucleosides effective against cancer and viral diseases. "
01/01/2011 - "Nucleosides have been shown to be effective as antiviral agents for other viral diseases and therefore, have been investigated as inhibitors of HCV replication. "
02/05/2002 - "hENT1 is involved in the uptake of natural nucleosides, including regulation of the physiological effects of extracellular adenosine, and transports nucleoside drugs used in the treatment of cancer and viral diseases. "