MPTP Poisoning

A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)

Also Known As:

Networked: 143 relevant articles (8 outcomes, 30 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Parkinson Disease (Parkinson's Disease)
2.	Parkinsonian Disorders (Parkinsonism)
3.	Dyskinesias (Dyskinesia)
4.	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome)
5.	Striatonigral Degeneration

Experts

1.	Schneider, J S: 7 articles (08/2008 - 06/2000)
2.	Mohanakumar, Kochupurackal P: 5 articles (04/2015 - 03/2005)
3.	Lim, Sabina: 4 articles (02/2013 - 01/2009)
4.	Choi, Yeong-Gon: 4 articles (02/2013 - 01/2009)
5.	Schroeder, J A: 4 articles (08/2002 - 06/2000)
6.	Yeo, Sujung: 3 articles (02/2013 - 04/2011)
7.	Hong, Yeon-Mi: 3 articles (02/2013 - 04/2011)
8.	Amit, Tamar: 3 articles (01/2010 - 01/2007)
9.	Gupta, Kailash Chand: 2 articles (12/2015 - 12/2013)
10.	Patel, Devendra Kumar: 2 articles (12/2015 - 12/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to MPTP Poisoning:

1.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA 10/01/2004 - "In moderately to severely impaired monkeys with bilateral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP)-induced parkinsonism receiving a unilateral RPE-GM implant in the putamen, there was a 39% improvement in clinical scores over the first 2 months post-implant. " 06/01/2007 - "In this study, using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism models, we investigated whether MPTP induces apoptosis of dopaminergic neurons through a GSK-3beta-dependent pathway. " 09/08/2005 - "In the present study, we investigated whether swim-test could be used as one of the behavioural monitoring techniques to study motor disability in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in two mouse strains, Balb/c and C57BL/6. Mice were treated with different doses of MPTP (10, 20 and 30 mg/kg, twice, 16 h apart), and were subjected to swim-test on the third day of the first MPTP injection. " 07/15/2005 - "To test the utility of the common coordinate system for functional imaging studies of minipig brain, we calculated cerebral blood flow (CBF) maps from normal minipigs and from minipigs with a syndrome of parkisonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-poisoning. " 05/01/2000 - "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism is one of the most useful models for the study of that disease. "
2.	Dihydroxyphenylalanine (Dopa)IBA 09/01/1997 - "Incorporation of DOPA into liposomes increases efficacy of its action in the medication of MPTP-induced parkinsonism in mice." 07/01/1999 - "NMSP binding to dopamine and serotonin receptors in MPTP-induced parkinsonism: relation to dopa therapy."
3.	resveratrolIBA 08/27/2008 - "Our results demonstrated that resveratrol could elicit neuroprotective effects on MPTP-induced Parkinsonism through free radical scavenging." 01/01/2015 - "Improved neuroprotective effects of resveratrol-loaded polysorbate 80-coated poly(lactide) nanoparticles in MPTP-induced Parkinsonism."
4.	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 12/01/2015 - "The results thus suggest that nanotization improves the protective efficacy of caffeine against MPTP-induced Parkinsonism owing to enhanced bioavailability, inhibition of the nuclear translocation of NF-κB and activation of protein kinase B phosphorylation."
5.	NicotineFDA Link 12/01/2013 - "Nicotine-encapsulated poly(lactic-co-glycolic) acid nanoparticles improve neuroprotective efficacy against MPTP-induced parkinsonism."
6.	Liposomes (Liposome)IBA 09/01/1997 - "Incorporation of DOPA into liposomes increases efficacy of its action in the medication of MPTP-induced parkinsonism in mice."
7.	Caffeine (No Doz)FDA LinkGeneric 12/01/2015 - "The results thus suggest that nanotization improves the protective efficacy of caffeine against MPTP-induced Parkinsonism owing to enhanced bioavailability, inhibition of the nuclear translocation of NF-κB and activation of protein kinase B phosphorylation."
8.	ML 23IBA 01/01/2005 - "On all parameters, ML-23 produced a significant remission from MPTP-induced Parkinsonism, and this effect did not abate when ML-23 treatment was withdrawn. "
9.	polylactic acid-polyglycolic acid copolymer (PLGA)IBA 12/01/2013 - "Nicotine-encapsulated poly(lactic-co-glycolic) acid nanoparticles improve neuroprotective efficacy against MPTP-induced parkinsonism."
10.	poly(lactide) (polylactide)IBA 01/01/2015 - "Improved neuroprotective effects of resveratrol-loaded polysorbate 80-coated poly(lactide) nanoparticles in MPTP-induced Parkinsonism."

Therapies and Procedures

1.	Deep Brain Stimulation 02/01/2009 - "In this study, the authors examined the intraoperative physiological characteristics and efficacy of subthalamic nucleus deep brain stimulation (DBS) in 1 of only 4 known living patients with MPTP-induced parkinsonism. "
2.	Acupuncture Points (Acupuncture Point) 07/15/2011 - "In this study, the gene expression profile changes following acupuncture at the acupoints were investigated in the cervical spinal cord of an MPTP-induced parkinsonism model using a whole transcript array (Affymetrix GeneChip mouse gene 1.0 ST array). " 02/25/2013 - "In this study, gene expression changes following acupuncture at the acupoints were investigated in the thalamus of a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism model using a whole transcript array. " 04/01/2011 - "This study investigated gene expression profile changes in the striatal region of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism models after acupuncture at the acupoints GB34 and LR3 using a whole transcript genechip microarray (Affymetrix genechip mouse gene 1.0 ST array). "
3.	Transplantation (Transplant Recipients) 01/01/1987 - "Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism."
4.	Intramuscular Injections 03/01/2013 - "A single intramuscular injection of rAAV-mediated mutant erythropoietin protects against MPTP-induced parkinsonism."
5.	Denervation 02/05/1993 - "These results would support the idea that in MPTP-induced parkinsonism, dopaminergic denervation results in a greater change in the D2 receptors, but furthermore would indicate a differential effect of levodopa/apomorphine exposure on the D1 and D2 receptor populations. "