1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)

01/01/2000 - "The present study investigates the efficacy of this compound to prevent the behavioral consequences of dopaminergic cell death in the best animal model of Parkinson's disease, the bilaterally MPTP-treated monkey. "
04/23/2015 - "Moreover, StA conferred significant protection against MPTP-induced loss of TH-positive dopaminergic neurons in a Parkinson's disease (PD) mice model. "
01/01/2012 - "In conclusion, the present results reveal the evidence that SHXT possesses beneficial protection against MPTP-induced neurotoxicity in this model of Parkinson's disease via its antioxidative and antiapoptotic effects. "
08/01/1986 - "Several classes of drugs useful in Parkinson's disease are effective in reversing MPTP-induced neurotoxicity. "
04/01/2015 - "In the present study, we investigated the protective effects of Sal in MPTP/MPP(+) models of Parkinson's disease in an attempt to elucidate the underlying mechanism of protection. "

11/01/1988 - "During the first few weeks following 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) administration, all monkeys gradually developed a parkinsonian syndrome, which partially, but not completely improved within 30-40 days in 2 animals. "
09/01/1995 - "2. The efficacy of D-1 receptor agonists in the treatment of experimental parkinsonism in MPTP-treated primates is demonstrated. "
08/15/2014 - "The present study exposed monkeys to higher MPTP doses to produce significant parkinsonism and behavioral impairments. "
06/01/2014 - "In the present study, parkinsonism was induced in cynomolgus monkeys by intravenous administration of MPTP (0.2 mg/kg) for 15 days; stable parkinsonism developed over 90 days, when the symptoms were stable. "
09/01/2011 - "The present study aims to determine the extent that motor and behavioral changes in aged monkeys resemble parkinsonism induced by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. "

02/01/1992 - "The MPTP monkey model remains very useful for predicting the potential of new drugs for inducing dyskinesia. "
01/01/2008 - "Recently, studies in MPTP-treated primates have suggested that a range of nondopaminerigic drugs might be useful in suppressing dyskinesia. "
01/01/2008 - "Recent studies in MPTP-treated primates have also suggested that switching from pulsatile drug delivery to CDD can be utilized to inhibit dyskinesia expression. "
07/01/2004 - "Relevance of the MPTP primate model in the study of dyskinesia priming mechanisms."
09/15/2012 - "Here we present an update on the practical use of rating scales for evaluating LID in MPTP-lesioned primate models of PD, with a focus on macaques, and present specifics on the Non-Human Primate Dyskinesia Rating Scale."

11/01/2008 - "Preconditioning failed to modify mPTP opening during ischemia alone, but significantly improved CRC during reperfusion. "
05/01/2013 - "Similarly, HDL, given as a preconditioning stimulus, improved cell survival and inhibited mPTP opening in isolated cardiomyocytes subjected to simulated ischemia. "
10/15/2015 - "We aimed to characterize mitochondrial calpains in the rat heart and to investigate the roles of calpains in mPTP opening after ischemia-reperfusion. "
05/01/2015 - "Through activation of the PI3K/Akt pathway and inhibition of the MPTP, PQS might protect the heart against ischemia injury and apoptosis of myocardial cells."
01/01/2015 - "Overexpression of bcl-2 attenuated MPTP opening in following ischemia-reperfusion. "

08/01/2008 - "These observations support our hypothesis that PostC is effective in salvage of ischemic skeletal muscle from reperfusion injury and the mechanism involves inhibition of opening of the mPTP."
02/15/2004 - "The functional recovery of the Langendorff-perfused heart from ischaemia inversely correlates with the extent of pore opening, and inhibition of the MPTP provides protection against reperfusion injury. "
07/15/2009 - "Recently, the benefits of both post-conditioning and inhibition of mPTP have been supported by proof-of-concept trials demonstrating the clinical applicability of strategies aimed at preventing lethal reperfusion injury. "
04/01/2015 - "Here we review the mechanisms and regulations of HK2 binding to mitochondria and how this inhibits mPTP opening and consequent reperfusion injury. "
01/01/2015 - "These data indicate that estrogen-Gper1 acute coupling plays a key role in cardioprotection against ischemia/reperfusion injury in male mouse via a cascade involving PKC translocation, ERK1/2/GSK-3β phosphorylation leading to the inhibition of the mPTP opening. "