Antioxidants

Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.

Networked: 7782 relevant articles (608 outcomes, 1340 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rahman, Irfan: 18 articles (06/2012 - 08/2002)
2.	Manoharan, Shanmugam: 16 articles (01/2013 - 01/2004)
3.	Dal-Pizzol, Felipe: 15 articles (02/2014 - 02/2004)
4.	Benghuzzi, Hamed: 14 articles (01/2015 - 01/2002)
5.	Tucci, Michelle: 13 articles (01/2015 - 01/2002)
6.	Agarwal, Ashok: 12 articles (11/2015 - 06/2004)
7.	Manoharan, S: 11 articles (10/2012 - 12/2002)
8.	Nagini, S: 11 articles (06/2010 - 06/2000)
9.	Sotgia, Federica: 10 articles (12/2015 - 01/2011)
10.	Lisanti, Michael P: 10 articles (12/2015 - 01/2011)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1996 - "On the other hand, numerous studies have demonstrated that diets rich in fruits and vegetables are protective against cancer, and have correlated high levels of antioxidants in the blood with decreased risk. " 01/01/2012 - "Antioxidants can neutralize ROS and decrease oxidative stress; however, this is not always beneficial in regard to disease formation or progression (of, e.g., cancer) or for delaying aging." 09/01/2011 - "These results clearly indicated that NEPPs from industrial apple waste could be a good source of natural antioxidants with significant antiproliferation efficacy against human cancer cells." 11/01/2007 - "Indeed, from recent high-quality epidemiological studies the image emerges that supplemental antioxidants may help to prevent cancer only in diet-deficient populations or individuals. " 02/01/1999 - "Numerous epidemiological studies have found strong associations between diets rich in antioxidant nutrients and a reduced incidence of cancer, and it has been suggested that a boost to the body's immune system by antioxidants might, at least in part, account for this. "
2.	Cardiovascular Diseases (Cardiovascular Disease) 07/01/2005 - "Despite the disappointments of recent large scale clinical trials evaluating the efficacy of antioxidants in cardiovascular disease, many therapeutic agents which have been used successfully in diabetic subjects at high risk for cardiovascular disease have a mechanism of action which includes an antioxidant capacity. " 01/01/2015 - "Several novel carriers based approaches have shown considerable benefits for the systemic and site specific delivery of antioxidants for the preventive and therapeutic treatment of several cardiovascular diseases. " 01/01/2011 - "Several epidemiological studies suggest that a diet rich in natural antioxidants is associated with protective effects against major diseases, especially cardiovascular disease. " 11/01/2008 - "Although several lines of evidence support a role for increased oxidative stress in a range of cardiovascular diseases, clinical trials examining the therapeutic efficacy of antioxidants have yielded conflicting results. " 01/01/2014 - "Antioxidants are effective in prevention and treatment of cardiovascular diseases. "
3.	Ischemia 09/01/1997 - "Our previous studies of cultured cardiomyocytes indicated that antioxidants are most effective when given prior to reperfusion during ischemia. " 12/01/2004 - "This is consistent with the hypothesis that ischemia is a major etiological factor in obstructive dysfunction, and treatment with antioxidants and membrane stabilization compounds such as those in the grape suspension can be effective in the treatment of obstructive bladder pathology." 05/01/2006 - "Protective effects of various antioxidants during ischemia-reperfusion in the rat retina." 07/01/1993 - "In many of the kidney models of ischemia-reperfusion, antioxidants are only partially effective in ameliorating the functional and morphologic alterations. " 01/23/1999 - "Neuroprotective efficacy of combination therapy with two different antioxidants in rats subjected to transient focal ischemia."
4.	Atherosclerosis 11/01/2003 - "Much experimental evidence suggests that lipid oxidation is important in atherogenesis and in epidemiological studies dietary antioxidants appear protective against cardiovascular events. " 03/01/2013 - "The lipid-lowering properties and antioxidants of the grape seed can be beneficial in atherosclerosis prevention. " 09/01/2000 - "There is reasonable evidence to suggest that antioxidants might be beneficial in preventing or retarding the progression of atherosclerosis. " 02/13/2004 - "[Is the supplementation with antioxidants effective in the treatment of atherosclerosis?]." 05/01/2002 - "This suggests that the antioxidants which suppress the oxidative modification of LDL should be effective in preventing atherogenesis. "
5.	Inflammation 01/01/2015 - "Epidemiological studies have shown that increased dietary intake of natural antioxidants is beneficial for health because of their bioactivities, including antioxidant and anti-inflammation actions. " 10/01/2014 - "Reducing ROS levels by treatment of antioxidants may be beneficial for preventing DS-associated inflammation by suppressing cytokine expression. " 01/01/2011 - "The use of antioxidants has been shown to be beneficial in stimulating immune cells to increase phagocytosis and up-regulating the cellular processes to limit inflammation. " 01/01/2010 - "The use of antioxidants has been shown to be beneficial in stimulating immune cells to increase phagocytosis and up-regulating the cellular processes to limit acute inflammation. " 01/01/2009 - "The use of antioxidants has been shown to be beneficial in stimulating immune cells to increase phagocytosis and up-regulating the cellular processes to limit acute inflammation. "

Related Drugs and Biologics

1.	Vitamin E
2.	Vitamins
3.	Ascorbic Acid (Vitamin C)
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	Enzymes
6.	Free Radicals
7.	Omega-3 Fatty Acids (Omega 3 Fatty Acids)
8.	Glutathione (Reduced Glutathione)
9.	Selenium
10.	Carotenoids (Carotene)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Chemoprevention
3.	Oral Administration
4.	Isogeneic Transplantation
5.	Mediterranean Diet