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Neurodegenerative Diseases (Neurodegenerative Disease)

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Hereditary and sporadic conditions which are characterized by progressive nervous system dysfunction. These disorders are often associated with atrophy of the affected central or peripheral nervous system structures.

Also Known As:

Neurodegenerative Disease; Neurodegenerative Disorders; Degenerative Diseases, Central Nervous System; Degenerative Diseases, Neurologic; Degenerative Diseases, Spinal Cord; Degenerative Neurologic Diseases; Degenerative Neurologic Disorders; Nervous System Degenerative Diseases; Neurologic Degenerative Conditions; Neurologic Degenerative Diseases; Neurologic Diseases, Degenerative; Degenerative Condition, Neurologic; Degenerative Conditions, Neurologic; Degenerative Neurologic Disease; Degenerative Neurologic Disorder; Neurodegenerative Disorder; Neurologic Degenerative Condition; Neurologic Degenerative Disease; Neurologic Disease, Degenerative; Neurologic Disorder, Degenerative; Neurologic Disorders, Degenerative; Degenerative Diseases, Nervous System

Networked: 16953 relevant articles (546 outcomes, 1302 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Parkinson Disease (Parkinson's Disease)
2.	Alzheimer Disease (Alzheimer's Disease)
3.	Neoplasms (Cancer)
4.	Stroke (Strokes)
5.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)

Experts

1.	Trojanowski, John Q: 75 articles (02/2015 - 05/2002)
2.	Lee, Virginia M-Y: 63 articles (02/2015 - 05/2002)
3.	Masliah, Eliezer: 58 articles (10/2015 - 02/2002)
4.	Youdim, Moussa B H: 50 articles (09/2015 - 01/2002)
5.	Mattson, Mark P: 44 articles (01/2015 - 01/2002)
6.	Butterfield, D Allan: 44 articles (10/2014 - 08/2002)
7.	Rubinsztein, David C: 35 articles (10/2015 - 05/2002)
8.	Perry, George: 35 articles (01/2015 - 01/2002)
9.	Smith, Mark A: 35 articles (10/2012 - 01/2002)
10.	Beal, M Flint: 34 articles (07/2014 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neurodegenerative Diseases:

1.	Proteins (Proteins, Gene)IBA 05/01/2014 - "Emerging studies have demonstrated that up-regulation of autophagy can lead to decreased levels of these toxic aggregate-prone proteins, and is beneficial in the context of aging and various models of neurodegenerative diseases. " 01/01/2005 - "Studies of proteins, cells, animal models, and humans suggest that treatments to diminish, or bypass, the reduction in KGDHC might be beneficial in age-related neurodegenerative disorders." 05/01/2014 - "Defect of autophagy is common to many neurodegenerative disorders because it serves as a major degradation pathway for the clearance of various aggregate-prone proteins. " 01/01/2014 - "Both cellular systems responsible for clearance of misfolded and aggregated proteins, the lysosomal and the proteasomal, have been shown to be malfunctioning in the aged brain and more so in patients with neurodegenerative diseases, including AD. " 08/01/2015 - "Its induction may accelerate the clearance of pathogenic proteins and promote cell survival, representing a potential therapeutic approach for the treatment of neurodegenerative diseases. "
2.	AntioxidantsIBA 07/01/2015 - "These in vitro assays indicate that this plant extract is a significant source of natural antioxidants, which may be helpful in preventing the progression of various neurodegenerative disorders associated with oxidative stress." 11/01/2012 - "Finally, we discuss how antioxidants, which have been considered to be beneficial in neurodegenerative diseases, can block autophagy, thus potentially compromising their therapeutic potential." 04/01/2009 - "In combination, antioxidants may be beneficial for promoting healthy brain aging and reducing the risk of neurodegenerative disease." 06/01/2005 - "Mitochondria under oxidative stress are thought to play a key role in various neurodegenerative disorders; therefore protection by antioxidants against oxidative stress to mitochondria may prove to be beneficial in delaying the onset or progression of these diseases. " 01/01/2015 - "Phytochemical-based antioxidants are shown to be effective in neurodegenerative diseases. "
3.	Amyloid (Amyloid Fibrils)IBA 08/01/2006 - "Complement activation may also reduce the accumulation of amyloid and degenerating neurons by promoting their clearance and suggest that certain inflammatory defense mechanisms in the brain may be beneficial in neurodegenerative disease. " 07/01/2013 - "These results confirmed that Gen could alleviate the mitochondria-targeted oxidative damage induced by β-amyloid 25-35 in C6 cells which might be useful for the treatment of neurodegenerative diseases." 05/12/2014 - "Inhibition of amyloid fibrillation and clearance of amyloid fibrils/plaques are essential for the prevention and treatment of various neurodegenerative disorders involving protein aggregation. " 04/03/2007 - "On the basis of data from mouse models of neurodegenerative diseases showing that exercise or environmental enrichment reduces the amyloid oligomer level and improves cognitive ability, we hypothesized that CryAB(R120G)-induced DRM would also respond favorably to prolonged voluntary exercise, reducing HF symptoms and rescuing the mice from premature death. " 08/01/2014 - "In this review, foci reside primarily on the amyloid β-peptide (Aβ) induced oxidative stress hypothesis and the proteomic studies that have been conducted by our laboratory and others that contribute to the overall understanding of this devastating neurodegenerative disease."
4.	MelatoninIBA 10/01/2010 - "Because stem cell replacement is thought to play an important therapeutic role in neurodegenerative diseases, melatonin might be beneficial for stimulating endogenous neural stem cells." 01/01/2015 - "Melatonin (MT) has been shown to be potentially effective in preventing oxidative stress related neurodegenerative disorders. " 05/01/2011 - "Relevance of the chronobiological and non-chronobiological actions of melatonin for enhancing therapeutic efficacy in neurodegenerative disorders." 01/01/2003 - "Melatonin, the main secretory product of the pineal gland, has been shown to be potentially effective in prevention of numerous types of neurodegenerative disorders in which free radical processes are involved. " 06/01/2002 - "Melatonin administration has been shown to be effective in counteracting the neurodegenerative conditions both in experimental models of neurodegenerative diseases and in patients suffering from such diseases. "
5.	Nerve Growth Factors (Neurotrophins)IBA 09/01/2001 - "Since neurotrophins themselves are not ideal drug candidates due to their poor pharmacokinetic behaviour and bioavailability, small molecule neurotrophin mimetics may be beneficial in treating a number of neurodegenerative disorders. " 11/01/2010 - "It is thought that the ability of human mesenchymal stem cells (hMSC) to deliver neurotrophic factors might be potentially useful for the treatment of neurodegenerative disorders. " 01/01/2012 - "Gene therapy holds much promise for the treatment of neurotrauma and neurodegenerative diseases; however, neurotrophic factors are known to alter dendritic architecture, and thus we set out to determine whether such transgenes also change the morphology of transduced neurons. " 11/10/1996 - "Neurotrophic factors hold promise for the treatment of neurodegenerative diseases. " 01/01/1994 - "For example, neurotrophins might function as long term mediators of changes in cellular shapes under the influence of electrical activity, as well as in pathological situations when axonal elongation is needed to restore connections, or to maintain the well-being of neurons that are eliminated during the course of neurodegenerative diseases."
6.	Glutamic Acid (Glutamate)FDA Link 01/01/2011 - "As a result, GCP inhibition is thought to be beneficial for the treatment of neurodegenerative diseases where excess glutamate is presumed pathogenic. " 04/01/2007 - "These data indicated that 3d and 4c have significant protective effect on nerve cell against glutamate injury, deserved to be further tested and maybe helpful for treatment of neurodegenerative disease." 12/01/2004 - "Taken together, our results demonstrate that the inhibition of glutamate release via activation of the CB1-cannabinoid receptor is one mechanism involved in Delta9-THC-induced impairment of spatial memory, and the therapeutic effect of Delta9-THC on EAE, and a Delta9-THC analog might provide an effective treatment for psychosis and neurodegenerative diseases." 12/09/2003 - "Because an increased glutamate outflow is thought to play a crucial role in triggering excitotoxic neuronal death, drugs able to regulate glutamate release could be effective for the management of neurodegenerative diseases. " 06/01/2003 - "Thus neuronal protection against glutamate-induced neurotoxicity is considered as an appropriate therapeutic strategy for preventing and treating neurodegenerative diseases. "
7.	Biological Markers (Surrogate Marker)IBA 06/01/2011 - "Biomarker development is important to the therapeutic imperative for neurodegenerative diseases, as biomarkers hold transformative promise for the design and conduct of clinical trials and, ultimately, for medical management of these diseases. " 12/01/2010 - "More importantly, they could be helpful in search for disease-modifying new therapies which are very much needed in modern approaches to treatment of neurodegenerative diseases, serving as surrogate endpoints in clinical trials. " 11/06/1998 - "Knowledge of etiology and pathogenesis, improved design of clinical trials, the development of biological markers, the advent of genetic animal models, the enhanced identification of susceptibility factors, and more effective drug delivery-such advances have improved the prospects for forestalling onset of illness and clinical decline in the growing numbers of people affected by neurodegenerative disorders." 12/01/2010 - "Genomic blood biomarkers hold great promise for development of novel clinical and therapeutic approaches in patients with neurodegenerative diseases. " 01/01/2014 - "Larger trials have to show whether they may serve as biomarkers and be helpful in monitoring patients with MS or neurodegenerative diseases. "
8.	Free RadicalsIBA 09/01/1999 - "These results provide evidence that intact, enzymatically active PUT-CAT is efficiently delivered to the nervous system following iv, ip, and sc administration and suggest that sc administration of PUT-CAT may be effective in treating neurodegenerative disorders in which the underlying mechanisms involve the action of free radicals and oxidative damage." 03/01/2015 - "Inula helenium has been reported to contain a large amount of phenolic compounds, which have shown promise in scavenging free radicals and prevention of neurodegenerative diseases. " 01/01/2012 - "Since free radicals are essential for brain physiological processes and pathological degeneration, research focusing on the possible influence of the EMFs-driven oxidative stress is still in progress, especially in the light of recent studies suggesting that EMFs may contribute to the etiology of neurodegenerative disorders. " 01/01/2009 - "Several studies demonstrated the involvement of free radicals in the pathophysiology of neurodegenerative diseases. " 01/01/2015 - "Similarly, free radicals are implicated in the progression of various diseases like neurodegenerative disorders. "
9.	Proteasome Endopeptidase Complex (Proteasome)IBA 01/01/2015 - "The UPS is reportedly downregulated in various neurodegenerative disorders, with increased proteasome activity shown to be beneficial in many related disease models. " 08/15/2012 - "Our results suggest that proteasomal activation may not always be beneficial for alleviating neurodegeneration and that blocking the proteasome may represent a potential therapeutic avenue for treating some forms of neurodegenerative disease." 08/01/2012 - "At variance with other inclusion bodies linked to neurodegenerative diseases, clearance of P56S-VAPB inclusions involves the proteasome, with no apparent participation of macro-autophagy. " 01/01/2014 - "Taken together, this study suggests that a decrease in proteasome activity can, through activation of c-Jun and ERK 1/2, result in several events related to neurodegenerative diseases. " 12/01/2002 - "Some recent studies reported that a proteasome dysfunction was involved in the pathogenesis of neurodegenerative diseases. "
10.	Estrogens (Estrogen)FDA Link 01/01/2004 - "Based on estrogen-inducible mechanisms, which have been elucidated in healthy neuron model systems, it would be predicted that estrogen therapy could be highly effective in preventing neurodegenerative disease by promoting neuronal defence and memory mechanisms. " 12/08/2009 - "In conclusion, our studies suggest that PTEN inactivation may be used as an important parameter for evaluation of the efficacy of estrogen in prevention of neuronal loss in neurodegenerative disorders." 06/01/2003 - "Experimental and epidemiologic studies as well as clinical trials have demonstrated that estrogen is beneficial for the course of neurodegenerative disorders such as Parkinson and Alzheimer diseases but may also protect neurons from postischemic neuronal degeneration. " 07/01/2011 - "Estrogens have been shown to have protective effects on a wide range of cell types and animal models for many neurodegenerative diseases. " 04/01/1999 - "Potential protective effects of the gonadal steroid estrogen on neurons are of particular interest in aging, neurodegenerative disease, and other traumatic conditions. "

Therapies and Procedures

1.	Transplantation (Transplant Recipients) 06/01/2008 - "The rhesus macaque is the most relevant preclinical model for assessing the benefit, safety, and efficacy of ESC-based transplantations in the treatment of neurodegenerative diseases. " 09/01/2012 - "Bone marrow mesenchymal stem cells (MSC) have been tested and proven effective in some neurodegenerative diseases, but their tracking after transplantation may be challenging. " 01/01/2010 - "These preliminary results further imply that NSC transplantation strategies might have therapeutic promise in treating neurodegenerative diseases often characterized by isolated or global neuronal and glialloss. " 07/01/2011 - "Genetic in vitro modification of pigment epithelial cells using nonviral transfection protocols should improve the potential therapeutic treatment of neurodegenerative diseases by transplantation of genetically modified cells without the disadvantages of virally mediated transfection. " 08/01/2010 - "These findings suggest that NSC, MHP36 transplantation may have therapeutic effects in the treatment of NP-C and other neurodegenerative diseases."
2.	Therapeutics 10/01/2014 - "Therefore, the structural properties, mechanism of formation, cytotoxic and/or protective effects, as well as the clinical impact of protein intermediates and aggregates will be reviewed here with the goal to establish a neurodegenerative disease model aimed at improving current therapeutics, which may ultimately contribute towards improved treatment modalities. " 01/01/2015 - "Neurotrophic factor genome engineering could have many potential applications not only in the deeper understanding of neurodegenerative disorders but also in improved therapeutics. " 01/01/2007 - "In addition, we discuss the drug discovery process and two approaches, function-driven and target-based, that show promise for development of neuroinflammation-targeted, disease-modifying therapeutics for multiple neurodegenerative disorders." 04/01/2015 - "In this review, we focus on the role of CSP in preventing neurodegeneration and discuss how recent studies of this universal neuroprotective chaperone are being translated into potential novel therapeutics for neurodegenerative diseases." 11/01/2014 - "The disheartening results of recent clinical trials for neurodegenerative disease (ND) therapeutics underscore the need for a more comprehensive understanding of the underlying disease biology before effective therapies can be devised. "
3.	Transplants (Transplant) 02/10/1997 - "Rats receiving chronic treatment with CsA at a dose of 10 mg kg-1, i.p., daily for 26 days, as used in neural transplants for animal models of neurodegenerative disorders did not significantly differ from vehicle-treated rats, and even appeared slightly improved, in retention of a passive avoidance task. " 01/01/2001 - "[10 years of substitution therapy for neurodegenerative diseases using fetal neuron grafts: a positive outcome but with questions for the future]." 12/01/2011 - "We identify the major recent advances in sourcing, preparation and delivery of primary and stem cell transplants into the brain, the preclinical studies in animal models and preliminary results on feasibility, safety and efficacy in an increasing range of human neurodegenerative diseases. " 11/20/2005 - "Sertoli cells are considered 'nurse cells' in the seminiferous tubules and have been used in cell graft protocols for neurodegenerative diseases and diabetes in many studies. " 01/01/2012 - "However, cellular transplants of neuroblasts derived from the aborted embryonic brain tissue in animal models of neurodegenerative disorders and in patients have demonstrated survival and functionality in the brain. "
4.	Cell Transplantation 05/01/2013 - "Although cell transplantation is increasingly suggested to be beneficial for the treatment of various neurodegenerative diseases, the therapeutic application of such intervention is currently hindered by the limited knowledge regarding central nervous system (CNS) transplantation immunology. " 04/01/1998 - "Neural cell transplantation is an emerging therapy that may provide an effective treatment for neurodegenerative disorders. " 01/01/2010 - "Cell transplantation emerged as possible alternative therapy, on the basis of animal studies showing that cells transplanted into the brain not only survive, but also lead to functional improvement in different neurodegenerative diseases. " 11/01/2013 - "These studies are already yielding important information for future approaches in the field of cell therapies in PD but also in other neurodegenerative disorders where cell transplantation therapy may be considered. " 01/01/2011 - "We show that, contrary to widespread assumption, medical termination of pregnancy-derived fetal brain cells represent a feasible and more readily available source of human fetal tissue for experimental cell transplantation with the potential for use in future clinical trials in human neurodegenerative disease."
5.	Immunotherapy 11/01/2003 - "Immunotherapy as a therapeutic treatment for neurodegenerative disorders." 01/01/2014 - "To produce safe and effective immunotherapies for AD and other neurodegenerative diseases it will be vital to understand the role of FcγR in the healthy and diseased brain. " 12/02/2015 - "The aim of our review is to address the translational aspects of neuroimmunology to describe the efficacy of immunotherapy in the treatment of pediatric neurodegenerative disorders. " 12/02/2015 - "The usefulness of immunotherapy in pediatric neurodegenerative disorders: A systematic review of literature data." 12/01/2013 - "Neurodegenerative disease: Tau immunotherapy targets transcellular propagation."