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Liposomes (Liposome)

Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.

Also Known As:

Liposome; Liposomes, Ultra-deformable; Liposome, Ultra-deformable; Liposome, Ultradeformable; Liposomes, Ultra deformable; Liposomes, Ultradeformable; Niosome; Transferosome; Ultra-deformable Liposome; Ultra-deformable Liposomes; Ultradeformable Liposome; Niosomes; Transferosomes; Ultradeformable Liposomes

Networked: 6877 relevant articles (811 outcomes, 1063 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Storm, Gert: 60 articles (12/2015 - 01/2002)
2.	Torchilin, Vladimir P: 54 articles (07/2014 - 12/2002)
3.	Oku, Naoto: 45 articles (11/2015 - 01/2002)
4.	Ueoka, Ryuichi: 44 articles (07/2015 - 04/2002)
5.	Zhang, Qiang: 39 articles (09/2015 - 05/2005)
6.	van Rooijen, Nico: 37 articles (12/2015 - 01/2002)
7.	Maruyama, Kazuo: 36 articles (10/2015 - 01/2002)
8.	Matsumoto, Yoko: 35 articles (07/2015 - 04/2002)
9.	Lee, Robert J: 35 articles (01/2015 - 01/2002)
10.	Koning, Gerben A: 32 articles (12/2015 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2014 - "Liposomes constitute one of the most popular nanocarriers for improving the delivery and efficacy of agents in cancer patients. " 01/01/2012 - "Liposomes have been widely investigated as one of the most widely used nanocarriers in cancer therapy and have shown their potential in spatial and temporal release of bioactive agents for the effective treatment of various life-threatening diseases, including cancer. " 03/01/2003 - "FR-targeted liposomes are a highly efficacious vehicle for in vivo delivery of anticancer agents and have potential application in the treatment of FR(+) solid tumors." 03/01/1999 - "Liposome-based chemoimmunotherapy is a synergistic and highly efficacious approach to eradicate metastatic and regionally spread tumors." 03/04/2013 - "More important, liposome-bound Apo2L/TRAIL overcame the resistance to soluble recombinant Apo2L/TRAIL exhibited by tumor cell mutants overexpressing Bcl-xL or by a Bax and Bak-defective Jurkat cell mutant (Jurkat-shBak) and are also effective against other hematologic tumor cells. "
2.	Infection 10/01/2009 - "The intramuscular immunization of mice with the peptide-liposome conjugates along with CpG resulted in the efficient induction of antiviral CD8(+) T-cell responses which conferred complete protection against not only LCMV Armstrong but also a highly virulent mutant strain, clone 13, that establishes persistent infections in immunocompetent mice. " 06/01/1998 - "Since the efficacy of gene therapy is dependent on the number of cells modified, which is in turn dependent upon the balance between transduction and biological clearance of the vector, the ability of cationic liposomes to form stable complexes with retroviral vectors and enhance their rate of infection is likely to be important for in vivo application." 08/01/2000 - "In comparison to the control mice immunized with phosphate-buffered saline and empty liposomes, immunization with free LAg led to significant levels of protection against infection with virulent promastigotes. " 06/01/1989 - "Moreover, the ability to increase the doses of CQ per injection after liposome encapsulation allowed successful treatment of infections with CQ-resistant Plasmodium berghei which could not be cured by a 7-day course with the maximum tolerable dose of free CQ of 0.8 mg/mouse/day." 04/01/2009 - "Our results indicate that photosensitizer entrapped in micelle exert similar or better PDI efficacy than that of liposome, which indicates this formulation may be useful for the treatment of local infections in the future."
3.	Neoplasm Metastasis (Metastasis) 12/28/2014 - "Inspired by their enhanced therapeutic efficacy and low organ toxicity, cRGDyk conjugated liposomes could serve as an effective drug system for targeted and synergistic therapy of bone metastases. " 01/01/1983 - "When mice bearing metastases are treated with macrophage-activating agents contained within liposomes, metastasis-associated macrophages are activated to the tumoricidal state and the metastatic lesions are simultaneously eradicated. " 10/14/2011 - "The in vivo fluorescence imaging and pharmacodynamic studies showed that LyP-1 modification increased liposome uptake by metastatic LNs and that L-LS/DOX significantly decreased metastatic LN growth and LN metastasis rate. " 01/01/1996 - "Potentials of liposomes in diagnosis and treatment of pulmonary metastases: an experimental study in the rat." 07/01/1984 - "The synergism between MAF and MDP encapsulated in liposomes was also observed in therapeutic studies of mice bearing well established, spontaneous lung and lymph node metastases. "
4.	Carcinoma (Carcinomatosis) 10/09/2008 - "The efficacy of these liposomes was studied in DU145 human prostate carcinoma cells. " 01/01/2012 - "In vitro cytotoxicity studies carried out on ER-positive MCF-7 breast carcinoma cells revealed that ES-pH-sensitive-SL formulation was more cytotoxic than non-pH-sensitive targeted liposomes (ES-SL). " 09/15/2005 - "The experiments in the current study provide a biologic rationale for treatment of patients suffering from pancreatic carcinoma with this nontoxic phytochemical encapsulated in liposomes for systemic delivery." 08/01/2005 - "The aggregation behaviour of human platelets and HT29 colon carcinoma cells in the presence of liposomes with a modified surface has been investigated in the present study. " 12/01/2015 - "Liposomes were then characterized by their size, zeta potential and cytotoxicity against C26 colon carcinoma cells. "
5.	Breast Neoplasms (Breast Cancer) 11/01/2012 - "The TQ-LP liposomes were effective in suppressing the proliferation of breast cancer cell lines MCF-7 and T47D, and at the same time exerting very low toxicity on normal periodontal ligament fibroblast. " 10/01/2015 - "The pharmacokinetics of free CDDP and the three ACP liposomes was determined using ICP-AES and their efficacy against EMT6-AR1 multidrug resistant murine breast tumor was compared. " 07/01/2014 - "The liposomes reported in this paper could potentially produce viable clinical strategies for improved targeting and delivery of DTX for the treatment of breast cancer." 01/01/2012 - "In this review, we discuss the recent advancements made in the development of liposome-based chemotherapeutics with respect to improved drug transfer for use in breast cancer therapy." 01/01/2008 - "To improvethe targeting efficacy for breast cancer treatment, an 8.3-kDa HER2-specific Affibody molecule (Z(HER2:342)-Cys) was conjugated to the surface of liposomes. "

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)
2.	Liposomes (Liposome)
3.	Antigens
4.	DNA (Deoxyribonucleic Acid)
5.	Clodronic Acid (Clodronate)
6.	Paclitaxel (Taxol)
7.	Carbon Monoxide
8.	Amphotericin B (Amphotericin)
9.	Cholesterol
10.	Ciprofloxacin (Cipro)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Drug Therapy (Chemotherapy)
3.	Immunotherapy
4.	Lasers (Laser)
5.	Injections