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Improved neuroprotective effects of resveratrol-loaded polysorbate 80-coated poly(lactide) nanoparticles in MPTP-induced Parkinsonism.

AbstractAIM:
This study investigated the neuroprotective effects of resveratrol (RVT)-loaded polysorbate 80 (PS80)-coated poly(lactide) nanoparticles in a mouse model of Parkinson's disease (PD), and compared these effects with those from bulk RVT.
METHODS:
C57BL/6 mice received for 15 days RVT intraperitoneally (nanoparticulate or non-nanoparticulate), as well as single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a neurotoxin that damages dopaminergic neurons and induces PD-related symptoms.
RESULTS:
MPTP induced significant impairments on olfactory discrimination and social recognition memory, as well as caused striatal oxidative stress and reduced the expression of tyrosine hydroxylase in striatum. RVT-loaded nanoparticles (but not bulk) displayed significant neuroprotection against MPTP-induced behavioral and neurochemical changes.
CONCLUSION:
These results point to RVT-loaded poly(lactide)-nanoparticles coated with PS80 a promising nanomedical tool and adjuvant therapy for PD.
AuthorsGabriela da Rocha Lindner, Danúbia Bonfanti Santos, Dirleise Colle, Eduardo Luiz Gasnhar Moreira, Rui Daniel Prediger, Marcelo Farina, Najeh Maissar Khalil, Rubiana Mara Mainardes
JournalNanomedicine (London, England) (Nanomedicine (Lond)) Vol. 10 Issue 7 Pg. 1127-38 ( 2015) ISSN: 1748-6963 [Electronic] England
PMID25929569 (Publication Type: Journal Article)
Chemical References
  • Antioxidants
  • Drug Carriers
  • Neuroprotective Agents
  • Polyesters
  • Polysorbates
  • Stilbenes
  • poly(lactide)
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Resveratrol
Topics
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Animals
  • Antioxidants (administration & dosage, therapeutic use)
  • Corpus Striatum (drug effects, metabolism, pathology, physiopathology)
  • Dopaminergic Neurons (drug effects, metabolism, pathology)
  • Drug Carriers (chemistry)
  • Male
  • Memory (drug effects)
  • Mice
  • Mice, Inbred C57BL
  • Neuroprotective Agents (administration & dosage, therapeutic use)
  • Olfactory Perception (drug effects)
  • Oxidative Stress (drug effects)
  • Parkinson Disease, Secondary (drug therapy, metabolism, pathology, physiopathology)
  • Polyesters (chemistry)
  • Polysorbates (chemistry)
  • Resveratrol
  • Stilbenes (administration & dosage, therapeutic use)

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