Elastin

11/01/2014 - "Rats in group B also had thickening intimal, degenerated matrix in media, loss of elastin fiber, apoptosis of vascular smooth muscle cells and transmural inflammation, none of which was observed in group A. "
09/01/2013 - "We propose that deep tissue injury encompasses elastin damage, yielding solubilized elastin that triggers inflammation. "
05/01/2013 - "It was shown that CYP2J2 overexpression attenuated matrix metalloproteinase expression and activity, elastin degradation, and AAA formation, which was associated with reduced aortic inflammation and macrophage infiltration. "
07/01/2012 - "Inflammation was found around the coronary artery of the model mice after 14 days, Elastin breakdown was observed after 56 days. "
04/01/2008 - "Sections were taken from the anterior, posterior, greater and lesser curvature of the aorta and graded in a semi-quantitative fashion for the degree of elastin fragmentation, elastin loss, smooth muscle cell (SMC) loss, intimal changes and inflammation. "

12/01/2006 - "More demanding wound models or long-term studies may yet reveal how fibulin-5 and elastin impact the quality of repair."
02/01/1994 - "The results of this study indicate that the polypentapeptide of elastin sheet is an effective physical barrier in this surgically induced contaminated wound model."
05/15/2014 - "The EpSC/PRP-treated wounds also exhibited increases in EpSCs, vascularization, elastin content, and follicle-like structures. "
09/01/2012 - "Elastin signaling in wound repair."
10/01/2010 - "Birth trauma appears to activate urethral elastin expression via TGFβ1 signaling. "

08/30/2005 - "The present study evaluated the functional benefits of increasing elastin within a myocardial scar using cell based gene therapy. "
04/01/1976 - "There are indications in this study that elastin imparts elasticity to the scar."
03/01/2014 - "The imaging properties of Gd-ESMA allow quantification of intrascar elastin content in vivo and thereby provide potential for noninvasive characterization of postinfarction scar remodeling."
03/01/2014 - "Gd-ESMA enables targeting of elastin within the infarct scar in a mouse model of MI. "
09/01/2012 - "In adult wound healing, elastin is severely lacking and only a disorganized elastic fiber network is present after scar formation. "

07/01/2012 - "Endothelial progenitor cell transplantation ameliorates elastin breakdown in a Kawasaki disease mouse model."
01/01/2014 - "Granulocyte colony-stimulating factor ameliorates coronary artery elastin breakdown in a mouse model of Kawasaki disease."
03/01/2011 - "Inhibition of transforming growth factor β worsens elastin degradation in a murine model of Kawasaki disease."
03/01/2008 - "Matrix metalloproteinase 9 activity leads to elastin breakdown in an animal model of Kawasaki disease."

08/01/1996 - "Compared with C57BL/6J mice, pallid mice showed a significantly greater lung elastin loss and a higher degree of emphysema after FMLP treatment. "
01/01/2012 - "In support of the human association studies, we cloned CD4 T cells with characteristic T helper (Th)1 and Th17 responses to EFs in the peripheral blood of ever-smokers with emphysema, confirming antigenicity of lung elastin in this population. "
05/01/1996 - "This hypothesis was tested in a clinical study by comparing EP concentration in male emphysematous patients with the level in two control groups, and by exploring the relation of elastin peptide level to high-resolution computed tomography (HRCT) scan emphysema score among emphysematous patients. "
12/01/1994 - "Although there is gathering evidence that elastin degradation is a part of the development of human emphysema, it is evident from studies in experimental emphysema that protease-antiprotease imbalance is not the only pathogenetic mechanism that gives rise to emphysema. "
07/01/2012 - "In the entire cohort of ex-smokers, cutaneous elastin degradation was associated with emphysema severity, FEV(1) and pulse wave velocity. "