Pancreatic Elastase (Elastase)

A protease of broad specificity, obtained from dried pancreas. Molecular weight is approximately 25,000. The enzyme breaks down elastin, the specific protein of elastic fibers, and digests other proteins such as fibrin, hemoglobin, and albumin. EC 3.4.21.36.

Also Known As:

Networked: 2886 relevant articles (96 outcomes, 333 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kallmes, D F: 27 articles (09/2015 - 04/2001)
2.	Kallmes, David F: 22 articles (12/2015 - 02/2002)
3.	Kadirvel, R: 22 articles (09/2015 - 01/2006)
4.	Dai, D: 21 articles (09/2015 - 01/2006)
5.	Lewis, D A: 18 articles (06/2012 - 01/2006)
6.	Ding, Y H: 17 articles (02/2013 - 01/2006)
7.	Upchurch, Gilbert R: 14 articles (02/2015 - 07/2003)
8.	Dai, Daying: 14 articles (11/2013 - 04/2003)
9.	Kadirvel, Ramanathan: 13 articles (12/2015 - 10/2005)
10.	Hwang, Tsong-Long: 13 articles (01/2015 - 01/2010)

Related Diseases

1.	Emphysema 08/01/1997 - "Genetic modification of critical components of the inflammatory process may be beneficial-for example, overexpressing anti-elastase genes may circumvent elastase mediated lung damage in emphysema. " 08/01/1998 - "AAT inhibits elastase and could be useful in the treatment of emphysema [169628]. " 10/01/2015 - "In this present study, we investigated emphysema development using the elastase-induced experimental emphysema model in two commonly used mouse strains, C57BL/6J and BALB/cJ. " 07/01/2015 - "In the present study, we evaluated the therapeutic effects of various doses of MSCs on elastase-induced emphysema in mice. " 06/29/2015 - "The aim of this study was to determine the possibility of using KGF gene therapy for treatment of a mouse emphysema model induced by porcine pancreatic elastase (PPE). "
2.	Infection 08/30/1991 - "Infection caused greater release of leucocyte elastase, complex levels were significantly greater in patients who were infected when compared to those who were not (463 +/- 84 micrograms/l; n = 13 compared to 180 +/- 46 micrograms/l; n = 17; P less than 0.01). " 01/01/2012 - "Elastase/LPS-exposed mice infected with NTHi showed persistence of bacteria up to 5 days after infection, whereas mice exposed to elastase, LPS, or PBS cleared all bacteria by 3 days. " 10/01/2009 - "Elastase-dependent live attenuated swine influenza A viruses are immunogenic and confer protection against swine influenza A virus infection in pigs." 09/01/1989 - "In the elastase administration group, the elastic fibers were eliminated or became minute, as in the infection groups. " 11/01/2008 - "Additional infection studies showed that NTHi mutants with biofilm defects were less persistent in the elastase-treated mice than the parent strain. "
3.	Exocrine Pancreatic Insufficiency 11/01/2001 - "The detection of pancreatic elastase 1 in stool samples has become the noninvasive gold standard for the diagnosis of pancreatic insufficiency in humans. " 04/01/2013 - "Twenty-six of 29 infants with a fecal elastase value <50 μg/g at study entry had a fecal elastase value <200 μg/g (the accepted cutoff value for pancreatic insufficiency) on all measurements during the year; all 29 had a value <200 μg/g at the end of the study. " 10/01/2014 - "Fecal elastase is a noninvasive test for pancreatic insufficiency diagnosis. " 09/01/2013 - "Exocrine pancreatic insufficiency was confirmed by low levels of fecal elastase. " 01/01/2012 - "Faecal elastase has been demonstrated to be of use in the diagnosis of pancreatic insufficiency. "
4.	Aneurysm (Aneurysms) 12/01/2013 - "An improved elastase-based method to create a saccular aneurysm rabbit model." 05/01/2007 - "A rabbit elastase aneurysm model has been helpful in the evaluation of devices and strategies involved in endovascular treatment of aneurysms. " 01/01/2006 - "To comprehensively test the efficacy of such flow divertors, we are implanting devices with three different porosities in a large cohort of elastase-induced aneurysms in rabbits. " 12/01/2015 - "In the current study, we describe a new model in which an elastase-treated donor aorta is transplanted to a recipient mouse and allowed to progress to aneurysm. " 06/01/2013 - "In the present study, we have percutaneously delivered autologous bone marrow mesenchymal stem cells (BMSCs) to an elastase-induced rabbit carotid aneurysm model in vivo. "
5.	Inflammation 07/01/1999 - "Especially for identifying patients in remission, the measurements of elastase seem to be more suitable than other parameters of inflammation, like CRP or ESR." 02/01/1993 - "Elastase used alone as a vaccine provided some protection against severe lung lesions and reduced the incidence of microscopic peribronchial inflammation. " 01/01/2014 - "This brief review considers recent studies eliciting the complex interaction between neutrophil-derived elastases and endogenous inhibitors that determines elastase-mediated inflammation in humans. " 07/01/2010 - "To elucidate the effects of inflammation on sperm quality, this study analysed classical sperm characteristics, leukocytes and elastase in neat semen, and sperm apoptotic markers, i.e. " 01/01/2005 - "This study was undertaken to determine whether intestinal inflammation alters fecal elastase concentration in dogs. "

Related Drugs and Biologics

1.	Chymotrypsin
2.	Antigens
3.	Secretin
4.	Tretinoin (Retinoic Acid)
5.	Serine (L-Serine)
6.	Caerulein (Ceruletide)
7.	Toxoids
8.	Leukocyte Elastase (Neutrophil Elastase)
9.	Trypsin
10.	Pancreatic Elastase (Elastase)

Related Therapies and Procedures

1.	Stents
2.	Tissue Therapy (Cell Therapy)
3.	Oral Administration
4.	Preoperative Period
5.	Angioplasty (Angioplasty, Transluminal)