Aneurysm (Aneurysms)

Pathological outpouching or sac-like dilatation in the wall of any blood vessel (ARTERIES or VEINS) or the heart (HEART ANEURYSM). It indicates a thin and weakened area in the wall which may later rupture. Aneurysms are classified by location, etiology, or other characteristics.

Also Known As:

Networked: 16930 relevant articles (613 outcomes, 1009 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Aneurysm (Aneurysms)
2.	Rupture
3.	Thrombosis (Thrombus)
4.	Pathologic Constriction (Stenosis)
5.	Hemorrhage

Experts

1.	Kallmes, D F: 48 articles (12/2015 - 02/2000)
2.	Levy, Elad I: 44 articles (10/2015 - 01/2002)
3.	Spetzler, Robert F: 42 articles (10/2015 - 09/2002)
4.	Kallmes, David F: 39 articles (12/2015 - 02/2002)
5.	Albuquerque, Felipe C: 39 articles (10/2015 - 09/2002)
6.	McDougall, Cameron G: 37 articles (10/2015 - 09/2002)
7.	Hopkins, L Nelson: 37 articles (03/2015 - 01/2002)
8.	Chalouhi, Nohra: 36 articles (12/2015 - 01/2012)
9.	Siddiqui, Adnan H: 36 articles (10/2015 - 02/2007)
10.	Jabbour, Pascal: 35 articles (12/2015 - 11/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aneurysm:

1.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 03/01/2013 - "Endovascular treatment with occlusion of the aneurysm including the parent vessel with coils or glue is the best treatment option." 06/01/2008 - "Separating the perforators from the neck or dome of the artery and preserving the parent vessel presents a substantial challenge to the surgeon when the aneurysm is behind the parent artery, making it difficult to achieve a good outcome." 01/01/2007 - "The following points should be considered for a good outcome: (1) experienced surgeon for bypass surgery, (2) experienced neuroradiologist for endovascular occlusion of the parent vessel as close to the aneurysm neck as possible, and (3) judicious postoperative management by means of anticoagulation, fluid replacement, and pressure control." 12/01/2012 - "The sandwich technique facilitates safe and effective aneurysm exclusion and target vessel revascularization in adverse anatomical scenarios, with sustained durability in midterm follow-up." 12/01/2006 - "The technique of BAC is attractive because the balloon theoretically allows for (1) "control" of blood flow in the vessel; (2) improved stability of the microcatheter in the aneurysm; (3) denser packing with coils; and (4) improved delineation of the neck of the aneurysm. "
2.	PlatinumIBA 10/01/2012 - "Four hundred thirty-three follow-up angiograms were assessed by the core laboratory; 127 of 215 (59%) and 118 of 218 (54%) in the Cerecyte and bare platinum groups, respectively, fulfilled the trial prespecified definition of success, namely that the treated aneurysm showed complete angiographic occlusion, had stable neck remnant, or improved in angiographic appearance compared with the end-of-treatment angiogram (P=0.17). " 03/14/2004 - "From our experiences, we conclude that the use of fibered electrolytically detachable platinum coils in aneurysm treatment leads to significantly improved occlusion rates compared to the sole use of bare platinum coils. " 07/01/2008 - "3T MRA is superior to 1.5T MRA for the assessment of aneurysms embolized with platinum coils; the combination of the 512 x 256 matrix and short TE (3.3 msec or less) seems feasible at 3T." 11/01/1999 - "Detachable platinum coil embolization is a safe treatment for unruptured aneurysms with a lower incidence of peri-procedural morbidity, wheareas follow-up results are less satisfactory in cases involving incompletely obliterated lesions. " 06/01/2004 - "Platinum microcoils coated with immobilized rhVEGF may be effective for the obliteration of aneurysms."
3.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 05/01/2015 - "We recruited 145 male patients, divided into controls (aortic diameter < 3 cm, n = 49), AAA not taking aspirin (AAA-Asp, n = 50) and AAA on 75 mg day(-1) aspirin (AAA+Asp, n = 46), matched for aneurysm size. " 01/01/2015 - "Treatment with aspirin also resulted in decreased expression of COX-2 within leukocytes within aneurysms as compared to peripheral blood samples. " 12/01/2014 - "Multivariate logistic regression, including CAWE, size, location, multiplicity of aneurysms, and daily aspirin intake, revealed that CAWE was the only independent factor associated with unstable status (odds ratio, 9.20; 95% confidence interval, 2.92-29.0; P=0.0002). " 06/01/2014 - "The majority of traumatic aneurysms can be managed with an antiplatelet regimen of 325 mg aspirin daily and serial imaging. " 08/01/2009 - "Patient 2 was treated with aspirin until coiling of the aneurysm could be performed. "
4.	Polytetrafluoroethylene (Teflon)FDA Link 01/01/1965 - "[STUDY OF PERIPHERAL HEMODYNAMICS IN ANEURYSMS OF THE ABDOMINAL AORTA AND AFTER INTERVENTION OF PROSTHETIC SUBSTITUTION IN TEFLON]." 04/26/2013 - "Another method is wrapping the aneurysm using newly developed expanded polytetrafluoroethylene (PTFE) material. " 04/01/2013 - "The orifice of the aneurysm was closed with expanded polytetrafluoroethylene (ePTFE) patch. " 11/01/2009 - "His SMA aneurysm was repaired with a PTFE patch. " 04/01/2008 - "The connection from the right pulmonary artery to the aneurysm was ligated, and the connection from the left atrium to the aneurysm was closed with a polytetrafluoroethylene patch. "
5.	Heparin (Liquaemin)FDA LinkGeneric 01/01/2005 - "The percentage of occlusion at the aneurysm orifice in animals treated with bFGF-immobilized coils (92.99+/-7.94%) was significantly greater than that in animals treated with heparin-coated coils (57.26+/-10.76%) or unmodified coils (52.86+/-8.54%). " 06/01/2004 - "rhVEGF-immobilized coils showed significantly greater endothelial formation at the aneurysm orifice and cell infiltration in the aneurysm body compared with the unmodified and heparin-coated coils. " 05/01/1976 - "We propose here criteria for establishing stable aneurysm as the cause of CCC and demonstrate the efficacy of heparin in reversing the coagulation defect prior to surgical intervention. " 12/01/2013 - "In patients with Fisher Grade 3 aSAH whose aneurysm is secured, postprocedure use of a low-dose intravenous heparin infusion may be safe and beneficial." 07/01/2013 - "Heparin boluses should be preferentially administered during aneurysm coiling."
6.	Pancreatic Elastase (Elastase)IBA 12/01/2013 - "An improved elastase-based method to create a saccular aneurysm rabbit model." 01/01/2006 - "To comprehensively test the efficacy of such flow divertors, we are implanting devices with three different porosities in a large cohort of elastase-induced aneurysms in rabbits. " 12/01/2015 - "In the current study, we describe a new model in which an elastase-treated donor aorta is transplanted to a recipient mouse and allowed to progress to aneurysm. " 06/01/2013 - "In the present study, we have percutaneously delivered autologous bone marrow mesenchymal stem cells (BMSCs) to an elastase-induced rabbit carotid aneurysm model in vivo. " 11/10/2011 - "The focus of this work was to evaluate whether a commonly used elastase induced aneurysm model in rabbits is suitable for a study of this kind from a hemodynamic perspective. "
7.	Polyethylene Terephthalates (Polyethylene Terephthalate)IBA 02/01/2007 - "This is a report of endotension with aneurysm expansion following Gore Excluder placement which was treated successfully with a dacron endograft." 02/01/1999 - "The aneurysm was repaired with a Dacron patch with good results. " 02/01/1995 - "In this study, 16 patients with an anteroseptal-lateral left ventricular aneurysm were treated by reconstruction of the left ventricle using a Dacron patch. " 10/01/2014 - "The aneurysm was closed off using a Dacron patch, and the sac was resected. " 02/01/2013 - "The authors sought to determine the prevalence of aneurysm formation in patients who previously underwent coarctation repair using Dacron(®) patch aortoplasty at their institution. "
8.	PolymersIBA 06/01/2015 - "The unique sealing technology of polymer filled endobags also provides an opportunity to treat aneurysm anatomies that could not be effectively treated with conventional endografts. " 05/01/2012 - "The experimental, simulation, and analytical results suggest that shape memory polymer foams have potential of being a safe treatment for intracranial saccular aneurysms. " 11/01/2006 - "Mean aneurysm volume was 114.7 mm(3), with a mean dome height of 5.2 mm and a neck width of 2.8 mm. The primary goal of this study was to assess the safety of this new polymer-loaded coil in terms of periprocedural, technical, or angiographic complications. " 08/01/2015 - "The Nellix device (Endologix, Irvine, Calif) employs a unique design with deployment of polymer-filled EndoBags surrounding the endograft flow lumens, sealing the aneurysm sac space and potentially reducing complications from persistent sac flow. " 01/01/2015 - "Vascular occlusion by PVA polymer coil proved superior in normal renal segmental arteries and feasible in surgically constructed carotid aneurysms (with packing densities ≥ 30%), constituting acceptable radiologic feasibility and histologic response."
9.	Intravenous Immunoglobulins (IVIG)FDA Link 08/01/2015 - "The clinical characteristics and laboratory data were compared between IVIG-sensitive and IVIG-resistant patients and also between patients with and without coronary artery aneurysm (CAA). " 07/15/2015 - "The best NLR cut-off value 2 days after IVIG for predicting aneurysm development was 1.01 (p <0.001). " 04/01/2014 - "A left ventricular aneurysm persisted even though the patient recovered with repeated high-dose IVIG treatment and cardiac supportive care. " 01/01/2013 - "Because IVIG-resistance increases risk of coronary artery aneurysms, our findings have important implications for the identification and treatment of such individuals." 10/01/2012 - "Approximately 10-30% of patients fail to respond to the initial IVIG and are at increased risk of coronary artery aneurysms. "
10.	Warfarin (Coumadin)FDA LinkGeneric 08/01/2010 - "CTA 3D volumetric aneurysm sac analysis showed an increase of 16.09% in the warfarin study group and a reduction of 9.71% in the antiplatelet group (P = .04). " 12/01/2013 - "Patients with symptomatic aneurysms, those without an initial ED coagulation screen and those on warfarin were excluded. " 03/01/2007 - "Strict monitoring of coagulation profile in patients after endovascular aneurysm repair requiring anticoagulation with warfarin is recommended to avoid this complication, which to our knowledge has not been previously reported." 03/01/2007 - "At 29 months, the patient had documented enlargement of the aneurysm sac associated with excessive anticoagulation with warfarin. " 12/01/2003 - "Fragile fresh clot was formed within the aneurysm irrespective of coumadin therapy as a standard regimen for the coronary artery ectasias. "

Therapies and Procedures

1.	Stents 10/01/2005 - "Randomized controlled trials of surgery versus covered stents are necessary to define the best treatment for large coronary artery aneurysms." 10/01/2000 - "Recently available highly flexible balloon expandable coronary stents improved the technique of endovascular aneurysm treatment. " 08/01/2015 - "stent provided excellent trackability and deliverability and is safe and effective for the treatment of wide-necked ACA aneurysms. " 06/01/2015 - "The LVIS Jr stent provided excellent trackability and deliverability and is safe and effective for the treatment of wide-necked MCA aneurysms with tortuous and smaller parent vessels." 10/01/2014 - "The Cardiatis multilayer stent (Cardiatis, Isnes, Belgium) is a flow-diverting bare stent with a proven efficacy in peripheral and visceral artery aneurysms. "
2.	Transplants (Transplant) 01/01/2009 - "Best treatment modality is surgical excision with repair with or without graft for aneurysms > 2.5 cm." 10/01/2007 - "Since 1991, more than 100,000 aneurysms worldwide have been repaired using early-generation and current-generation standardized grafts and this has dramatically reduced the 30-day mortality rates associated with open aortic surgery. " 11/04/1997 - "Use of a composite valve graft theoretically confers more protection against recurrent aortic root aneurysm, and, unless one opts for a valve-sparing aortic root replacement procedure, is most appropriate for younger patients, those with the MFS (including acute dissections), and others with marked pathological involvement of the sinuses. " 01/01/2006 - "In this report, we present the case of a patient who was treated successfully with an endovascular graft for a mycotic saccular aneurysm located just below the left subclavian artery." 08/01/1997 - "Endovascular grafts appear to be a safe and effective technique for excluding some noninfected aortoiliac anastomotic aneurysms in high-risk patients and may become a treatment option in all patients who have clinically significant lesions."
3.	Endovascular Procedures 06/01/2010 - "The International Subarachnoid Aneurysm Trial study suggests that an endovascular procedure is the best treatment. " 01/01/2006 - "This study showed that EVT of MCA aneurysms is feasible with good results in most patients thanks to new endovascular techniques. " 06/01/2011 - "While endovascular techniques may aid in management, surgery remains the most effective treatment for complex aneurysms of the pancreaticoduodenal arteries." 01/01/2010 - "The endovascular procedure was extremely effective for the treatment of this inflammatory iliac artery aneurysm." 08/01/2014 - "We present two cases of common iliac artery aneurysms treated by modified endovascular techniques with good results. "
4.	Surgical Instruments (Clip) 08/01/2012 - "However, endovascular therapy removes simple aneurysms that would have been easiest to clip with the best results. " 06/01/2007 - "Most of the classifications of aneurysms at present are based on size, location or pathology which are effective for the description but are less useful in preoperative planning and also in deciding on the technique or type of clip application. " 03/01/2015 - "The double-clip technique is a safe and effective variation of booster clipping in the treatment of very small aneurysms with suitable morphology." 04/01/2008 - "Intraoperative neuromonitoring in aneurysm surgery can be very useful to determine inadequate positions of the vascular clip that cause partial or complete compromise of the cerebral sanguineous flow in the vascular territories irrigated by the arteries related to aneurysm. " 01/01/2013 - "The supraorbital route is recommended for selected anterior circulation aneurysms based on the improved surgical instruments and microsurgical skills."
5.	Ligation 11/01/1982 - "On the basis of our experience, ligature and resection is considered the best treatment for large aneurysms. " 11/01/1989 - "Embolization with ligation proved very effective in clotting the intraaneurysmal blood in this case and would appear to be the treatment of choice for very large aneurysms. " 06/01/2011 - "The patient was treated successfully with right renal to common hepatic artery bypass followed by aneurysm ligation and excision. " 05/01/2007 - "She was treated successfully with open surgery including ligation of multiple branch aneurysms and vein bypass reconstruction to preserve hepatic and mesenteric artery flow. " 03/01/1991 - "In this particular case successful therapy consisted of ligation of the anterior humeral circumflex artery proximal and distal to the aneurysm, resection of the aneurysm, and transcubital thromboembolectomy."