Hydrogels

Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed)

Networked: 661 relevant articles (53 outcomes, 88 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tabata, Yasuhiko: 13 articles (12/2014 - 01/2003)
2.	Gerecht, Sharon: 8 articles (12/2015 - 12/2011)
3.	Burdick, Jason A: 8 articles (05/2015 - 04/2011)
4.	Singh, Baljit: 8 articles (04/2014 - 08/2008)
5.	Prestwich, Glenn D: 7 articles (06/2010 - 03/2006)
6.	Syková, Eva: 6 articles (11/2015 - 10/2006)
7.	Mooney, David J: 6 articles (09/2014 - 07/2007)
8.	Xu, Keming: 5 articles (01/2016 - 09/2005)
9.	Chen, Xuesi: 5 articles (01/2016 - 12/2013)
10.	Bryant, Stephanie J: 5 articles (02/2015 - 06/2010)

Related Diseases

1.	Wounds and Injuries (Trauma) 05/01/2015 - "Despite this, the presence of transfected cells shows promise for the use of polyplex-loaded porous hydrogels for local gene delivery in the treatment of diabetic wounds. " 12/01/2014 - "Cyclodextrin-based hydrogels toward improved wound dressings." 09/01/2002 - "Use of locally applied occlusive hydrogels holds promise for hemostasis and local wound control during laparoscopic urologic procedures." 10/20/2015 - "In vivo wound healing studies, conducted on a rat model of excised wound indicated that after 5 days ALG/HA hydrogels significantly promoted wound closure as compared to ALG ones (p<0.001). " 11/01/2012 - "In vivo wound healing study was performed by injecting hydrogels on rat dorsal wounds. "
2.	Neoplasms (Cancer) 01/01/2013 - "Encapsulation of therapeutically engineered stem cells in hydrogels has been utilized to provide a physical barrier to protect the cells from hostile extrinsic factors and significantly improve the therapeutic efficacy of transplanted stem cells in different models of cancer. " 03/01/2002 - "Therapeutic efficacy of IL-2-loaded hydrogels in a mouse tumor model." 04/07/2014 - "Low-molecular weight hydrogels have already shown promise in biomedical applications as diverse as 3D-cell culture, enzyme immobilization, controllable MSC differentiation, wound healing, drug delivery etc. Here we review the recent development in the use of low-molecular weight hydrogels for cancer therapy, which may be helpful in the design of soft materials for drug delivery. " 12/01/2013 - "Therefore, the polypeptide-based thermosensitive hydrogels designed in the present study have great potential to serve as an effective platform for localized anti-cancer drug delivery." 03/28/2013 - "Histological studies confirmed that tumor tissues in mice treated with IFN-α2a-incorporated HA-Tyr hydrogels showed lower cell density, with more apoptotic and less proliferating cells compared with tissues treated with an IFN-α2a solution. "
3.	Myocardial Infarction 11/01/2012 - "Epicardial application of HA-blood hydrogels improved left ventricular ejection fraction following myocardial infarction (p=0.01). " 03/01/2015 - "Hydrogels are being actively investigated for direct delivery of cells or bioactive molecules to the heart after myocardial infarction (MI) to prevent cardiac functional loss. " 03/01/2015 - "Hydrogels with integrin-binding angiopoietin-1-derived peptide, QHREDGS, for treatment of acute myocardial infarction." 08/26/2014 - "To evaluate this hypothesis, a rat model with acute myocardial infarction was used, and the therapeutic hydrogels were injected intramyocardially in the peri-infarct regions. " 11/01/2012 - "HA-blood hydrogels are highly adhesive, biodegradable, promote CDC survival and increase cardiac function following epicardial application after myocardial infarction."
4.	Inflammation 06/08/2015 - "The therapeutic effect of HA hydrogels was further investigated in IL-1β induced inflammation on NP cell cultures and the mechanism of HA by examining the expression of cell surface receptor of CD44. " 01/01/2015 - "There were no signs of increased inflammation due to the application of the hydrogels. " 01/01/2014 - "HA-based hydrogels, especially as a vehicle for stem cells, have been demonstrated to improve the process of cardiac repair by stimulating angiogenesis, reducing inflammation, and supporting local and grafted cells in their reparative functions. " 12/01/2012 - "Transduction rate can be controlled by the hydrogels' polyHis concentration and is sensitive to localized decreases in pH consistent with inflammation. " 04/01/2011 - "Based on the results obtained, it can be concluded that the prepared hydrogels have appropriate technological parameters and therefore in the future they may become potential drugs for the treatment of various inflammations in the oral cavity."
5.	Infection 12/01/2014 - "Hence, it was clear that the developed hydrogels can be used effectively for preventing and treating infections." 08/01/2014 - "The up-regulation of NTCP expression and restoration of hepatocyte-like polarity in our hydrogels also shed light on future study of hepatitis B virus infection in vitro." 01/09/2013 - "This study not only broadened the application and opened up a new door for biomedical applications of molecular hydrogels but also might provide a novel strategy to counteract infection diseases through selective surface-induced hydrogelations at pathogens, such as bacteria and virus." 04/01/2015 - "To be efficient, vaginal microbicide hydrogels should form a barrier against viral infections and prevent virus spreading through mucus. " 01/01/2015 - "To this end, in the last few years many hydrogels have been designed as matrices for antimicrobial molecules destined to fight frequent infection found in moist environments like the oral cavity. "

Related Drugs and Biologics

1.	Hydrogel
2.	Polymers
3.	Gelatin
4.	Collagen
5.	Gels
6.	Paclitaxel (Taxol)
7.	Dextrans (Dextran)
8.	Polyhydroxyethyl Methacrylate (PHEMA)
9.	Collagen Type I (Type I Collagen)
10.	tebufenozide (Mimic)

Related Therapies and Procedures

1.	Injections
2.	Debridement
3.	Drug Therapy (Chemotherapy)
4.	Microspheres (Microsphere)
5.	Transplants (Transplant)