Collagen

A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).

Also Known As:

Networked: 31722 relevant articles (1031 outcomes, 2940 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhang, Wei: 42 articles (01/2016 - 04/2002)
2.	Risteli, Juha: 34 articles (08/2015 - 07/2002)
3.	Bonaldo, Paolo: 33 articles (10/2015 - 12/2003)
4.	Holmdahl, Rikard: 32 articles (08/2014 - 01/2002)
5.	Sener, Göksel: 32 articles (04/2012 - 09/2004)
6.	Gedik, Nursal: 32 articles (09/2008 - 09/2004)
7.	Zhang, Yun: 30 articles (01/2016 - 10/2004)
8.	Heemskerk, Johan W M: 29 articles (06/2015 - 08/2002)
9.	Samuel, Chrishan S: 28 articles (12/2014 - 10/2002)
10.	Díez, Javier: 25 articles (01/2016 - 05/2002)

Related Diseases

1.	Fibrosis (Cirrhosis) 12/01/2014 - "A significant decrease in collagen deposition and reduced expression of alpha-smooth muscle actin (α-SMA) protein indicated that IL-30-based gene therapy dramatically reduced bridging fibrosis that was induced by CCl4 or DDC. " 12/01/2013 - "Furthermore, DOW-AC also had more potent effect on protection against TAA-induced liver damage and fibrosis according to the results of H&E stain and collagen stain. " 04/03/2012 - "Compared with the group B, the pathological stages of hepatic fibrosis in group D and E were significantly reduced (P < 0.05), the expression of collagen were decreased, ultrastructural alterations were markedly improved. " 04/01/2009 - "More importantly, these changes in gene expression were associated with marked attenuation of lung fibrosis, including decreased collagen deposition and improved lung function and survival. " 01/01/1999 - "Finally, the observation that culture of RPT cells on a reconstituted basement membrane preparation results in a significant reduction in total collagen production and alterations in the molecular forms of type IV and type I molecules synthesized indicates that integrity of the tubular basement membrane may represent an important component in preventing the development of tubulointerstitial fibrosis."
2.	Wounds and Injuries (Trauma) 01/01/2015 - "Improved re-epithelization, reduced inflammatory infiltration and increased collagen deposition were observed in biopsies from wounds treated with ASCs, with the best result in the autologous setting. " 10/01/2001 - "These results show that the application of TGF-beta(1) treated collagen matrix is effective for preventing contraction producing so called "neodermis" in treating a delayed healing type model and may be highly beneficial for treating chronic wounds." 02/01/1981 - "The healing wounds in the glandular oxyntic part of the stomach and duodenum showed the most rapid increase in collagen concentration in the incision line and 40 days postoperatively both had collagen concentrations significantly greater than those of intact tissues. " 01/01/2012 - "The gradual pbFGF release revealed significantly higher wound recovery rate with improved vascularization, enhanced collagen deposition and maturation, complete re-epithelialization and formation of skin appendages. " 01/01/2011 - "Wound healing study revealed significant reduction in wound size and mean epithelisation time, and higher collagen synthesis in the 2% extract-treated group compared to the vehicle group. "
3.	Cicatrix (Scar) 11/01/2009 - "Focusing on quantitation of deposited collagen, the Scar-in-a-Jar was most effective in assessing novel inhibitors that may have multiple targets, such as microRNA29c, found to be a promising antifibrotic agent. " 02/01/2015 - "Moderately resected hearts had 15±2% of the wall infiltrated by a collagen scar; significantly greater scar infiltration (23±4%) was observed in hearts with large resections. " 09/01/2013 - "The collagen implant significantly improved the bioelectrical characteristics, gross appearance and tissue alignment of the healed, treated tendons, compared to the healed, control scars. " 06/07/2011 - "In both repair groups there was a significant reduction in collagen staining between 6 and 12 weeks, suggestive of scar remodelling. " 07/01/2004 - "ECG showed a significant improvement in the quality of scar formation both in terms of maturity and orientation of the collagen fibers. "
4.	Inflammation 01/01/1987 - "These results show that DP could be effective in preventing damage of chondrocytes and inhibition of collagen biosynthesis in them, phenomena important in cartilage destruction induced by a chronic immunological inflammation." 12/01/2013 - "This was associated with a significant reduction in post-operative proliferation, inflammation and angiogenesis during the first post-operative days after surgery, and with a decrease in collagen deposition at later stages. " 03/01/2013 - "Group V (12 weeks) showed significantly improved collagen organization versus other treatment groups; there was no difference in collagen organization in Group I versus V. In summary, increased cellularity, inflammation, vascularity, and collagen organization were present at 3 weeks; increased collagen organization at 12 weeks in Group V provides evidence for improved healing with cells. " 12/01/2012 - " Treatment significantly improved the clinical performance, cell, collagen and tissue maturation, tissue alignment and remodeling, ultimate strength, stiffness, maximum stress, and dry weight content and decreased the tendon diameter, inflammation, adhesions and degeneration of the injured treated tendons compared to the injured control ones. " 03/01/2010 - "The results demonstrated significant differences between G2 and G3, and between G2 and G4, at both 3 days and 7 days, with regard to acute inflammation scores; G1 and G2 showed significant differences when compared with G4 at 3 days, with regard to neo-angiogenesis scores; G1 and G2 were statistically different from G3 and G4 at both 3 days and 7 days, with regard to re-epithelization scores; G2 showed statistically significant differences when compared with G3 and G4 with regard to collagen fiber scores at 7 days. "
5.	Keratoconus 11/01/2015 - "Collagen crosslinking is cost effective in 85% of simulations at a willingness-to-pay threshold of £30 000 per QALY.ConclusionUVA collagen crosslinking is very likely to be cost effective, compared with standard management, for the treatment of progressive keratoconus. " 08/01/2013 - "Collagen cross-linking has been reported to be effective in treating progressive keratoconus, and this study aims to evaluate the long-term efficacy of this procedure. " 09/01/2010 - "The results of this study indicate that collagen cross-linking appears to be an effective therapeutic option for progressing keratoconus. " 02/01/2009 - "The results of this study indicate that collagen cross-linking appears to be an effective therapeutic option for progressing keratoconus. " 11/01/2011 - "Corneal collagen cross-linkage appears to be an effective and safe modality to halt the progression of keratoconus. "

Related Drugs and Biologics

1.	Riboflavin (Vitamin B2)
2.	Hydroxyproline (4 Hydroxyproline)
3.	Bleomycin (Blenoxane)
4.	Messenger RNA (mRNA)
5.	Fibronectins (Fibronectin)
6.	Thrombin
7.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
8.	Antibodies
9.	Transforming Growth Factor beta (TGF-beta)
10.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Lasers (Laser)
3.	Sutures (Suture)
4.	Injections
5.	Photorefractive Keratectomy