Extracellular Matrix Proteins

Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).

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Networked: 1319 relevant articles (9 outcomes, 85 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Blaheta, Roman A: 7 articles (12/2012 - 04/2006)
2.	Kato, Mitsuo: 4 articles (09/2015 - 12/2006)
3.	Natarajan, Rama: 4 articles (09/2015 - 12/2006)
4.	Zhuang, Shougang: 4 articles (01/2014 - 08/2010)
5.	Distler, Jörg H W: 4 articles (06/2013 - 12/2007)
6.	Distler, Oliver: 4 articles (06/2013 - 12/2007)
7.	Hudak, Lukasz: 4 articles (12/2012 - 01/2009)
8.	Wedel, Steffen: 4 articles (12/2012 - 11/2007)
9.	Juengel, Eva: 4 articles (12/2012 - 01/2009)
10.	Distler, O: 4 articles (01/2010 - 06/2002)

Related Diseases

1.	Neoplasms (Cancer) 03/01/1995 - "The present study suggests a heterogeneity in the distribution of basement membrane and extracellular matrix proteins in skin appendage tumors and elucidation of their functional roles would assist in understanding the changes in the supporting tumor stroma following neoplastic changes." 11/01/1992 - "Future studies of binding of both myeloma cell lines and freshly isolated tumor cells to extracellular matrix proteins and to marrow stroma may enhance our understanding of localization and trafficking of cells within the bone marrow microenvironment." 03/01/2015 - "Tumor microenvironment is composed of all the untransformed elements in the vicinity of tumor, mainly including a large number of stromal cells and extracellular matrix proteins, which play an active role in most solid tumor initiation and progression. " 01/01/2015 - "We report a novel adaptation of the Radial Monolayer Cell Migration assay, first reported to measure the radial migration of adherent tumor cells on extracellular matrix proteins, for measuring the motility of fluorescently-labeled, non-adherent human or murine effector immune cells. " 07/24/2014 - "Fibulins (FBLNs), a family of extracellular matrix proteins, have recently been shown to act as tumor suppressors or activators in different cancers, and the underlying molecular mechanisms of their action in cancer remain unclear. "
2.	Breast Neoplasms (Breast Cancer) 11/01/2008 - "In the present study, we initially observed increased cell adhesion to extracellular matrix proteins by the MDR human breast tumor cell line MCF-7/MX compared to its parental cells. " 07/01/1997 - "[Immunohistochemical study of oncogene c-erbb-2 expression and extracellular matrix proteins in breast cancer (various mechanisms of invasion)]." 04/01/2002 - "Extracellular matrix proteins influence phenotype and cytokine expression in human breast cancer cell lines." 04/01/1999 - "Thrombospondin-1 and -2 are extracellular matrix proteins that are overexpressed in breast cancer tissue. " 02/01/2006 - "Effect of apoptosis and response of extracellular matrix proteins after chemotherapy application on human breast cancer cell spheroids."
3.	Fibrosis (Cirrhosis) 01/01/2016 - "Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions. " 12/01/2015 - "Matrix metalloproteinase (MMP) which degrade extracellular matrix proteins, contributing to inflammatory cell recruitment, tissue injury and fibrosis are also up-regulated in the lung after SM exposure. " 11/26/2015 - "Cardiac fibrosis is regulated by a myriad of factors that converge on the transcription of genes encoding extracellular matrix proteins, a process the epigenetic machinery plays a pivotal role. " 01/01/2015 - "Fibrosis is characterized by excessive production and deposition of extracellular matrix proteins with a detrimental impact on organ function. " 02/01/2014 - "Extracellular matrix proteins: a positive feedback loop in lung fibrosis?"
4.	Neoplasm Metastasis (Metastasis) 03/01/2015 - "The resistant cells were characterized by loss of differentiation, induction of transformation, enhanced expression of the lysosomal compartment, increased potential for metastasis, migration, adherence and Ca2(+) ion binding, enhanced expression of the MAPK pathway and extracellular matrix proteins, and epithelial-mesenchymal transformation. " 04/01/2010 - "IL-1beta-stimulated cells expressed the metastasis promoter S100A4, increased secretion of active MMP-9 and MMP-2 and invasion of extracellular matrix proteins. " 09/01/2009 - "The former is associated with the degradation of the extracellular matrix proteins, which is a process required for tumour cell invasion and metastasis. " 11/01/2002 - "Its increased expression and secretion in tumour cells may facilitate the degradation of extracellular matrix proteins, leading to tumour cell invasion and metastasis. " 04/15/1996 - "Extracellular matrix proteins with attachment properties are generally believed to play a key role in tumorigenesis and metastasis formation. "
5.	Hypertrophy 05/14/2004 - "These changes include an excess deposition of extracellular matrix proteins into the glomerular basement membrane and renal mesangial cell hypertrophy. " 05/01/1997 - "The effect of treatment on vascular hypertrophy was assessed by quantitative morphometry and on the vascular extracellular matrix proteins and BBB permeability alterations by immunohistochemistry. " 01/01/1997 - "production and composition of the extracellular matrix proteins, determine a physiological or pathophysiological hypertrophy. " 08/01/2015 - "Hyperglycemic culture conditions, similar to that present in diabetes, were sufficient to elevate mesangial cell HexCers and increase markers of fibrosis, extracellular matrix proteins, and cellular hypertrophy. " 01/01/2014 - "Histological alterations in DM include early hypertrophy of glomerular and tubular components, subsequent thickening of basement membrane in glomeruli and tubules, progressive accumulation of extracellular matrix proteins in the glomerular mesangium and loss of podocytes, together constituting a clinical condition referred to as diabetic nephropathy (DN). "

Related Drugs and Biologics

1.	Fibronectins (Fibronectin)
2.	Transforming Growth Factor beta (TGF-beta)
3.	Intercellular Signaling Peptides and Proteins (Growth Factors)
4.	Collagen Type I (Type I Collagen)
5.	Tenascin
6.	Matrix Metalloproteinases
7.	Matrix Metalloproteinase 9 (Gelatinase B)
8.	Hydrogels
9.	Glucose (Dextrose)
10.	glycosylated serum albumin

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Ligation
4.	Transplants (Transplant)
5.	Homologous Transplantation (Allograft)