DNA Polymerase gamma

A DNA-directed DNA polymerase that functions in the replication of MITOCHONDRIAL DNA. Mutations in the gene that encodes this enzyme (POLG) are associated with some forms of OPHTHALMOPLEGIA, CHRONIC EXTERNAL PROGRESSIVE.

Also Known As:

Networked: 165 relevant articles (1 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Copeland, William C: 11 articles (04/2013 - 05/2002)
2.	Suomalainen, Anu: 8 articles (08/2013 - 09/2004)
3.	Bindoff, Laurence A: 7 articles (01/2021 - 09/2005)
4.	Longley, Matthew J: 7 articles (08/2010 - 05/2002)
5.	Johnson, Kenneth A: 6 articles (01/2015 - 12/2003)
6.	Kaguni, Laurie S: 5 articles (01/2016 - 07/2005)
7.	Zeviani, Massimo: 5 articles (05/2010 - 08/2002)
8.	Baruffini, Enrico: 4 articles (01/2020 - 10/2006)
9.	Prolla, Tomas A: 4 articles (11/2018 - 07/2008)
10.	Majamaa, Kari: 4 articles (11/2018 - 09/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "DNA polymerase gamma (PolG) has been implicated in mitochondrial homeostasis and affects the development of numerous types of cancer, however, its effects on GC and molecular mechanisms remain to be fully determined. " 06/01/2017 - "Genetic variants in mitochondrial DNA polymerase-γ (POLG) have been associated with several malignancies. " 01/01/1970 - "[Mitochondrial DNA-polymerase from tumor and normal tissues]." 01/01/2018 - "Inflammation-induced DNA methylation of DNA polymerase gamma alters the metabolic profile of colon tumors." 05/01/2008 - "DNA polymerase gamma inhibition by vitamin K3 induces mitochondria-mediated cytotoxicity in human cancer cells."
2.	Burkitt Lymphoma (Burkitt's Lymphoma) 07/15/1978 - "DNA polymerase alpha + beta and DNA polymerase gamma activity were indiscriminately high in all immature cells as found in ALL, AML, Burkitt's lymphoma and phytohemagglutinin-stimulated normal lymphocytes, when compared to mature leukocytes found in normal individuals or in patients whose cancer was in remission. "
3.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2020 - "Mutations in human gene encoding the mitochondrial DNA polymerase γ (HsPolγ) are associated with a broad range of mitochondrial diseases. " 01/01/2018 - "Polg is the only mitochondrial DNA polymerase and mutations in Polg cause mitochondrial diseases in humans. " 01/01/2017 - "A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma." 01/01/2016 - "Mutations in the nuclear gene POLG (encoding the catalytic subunit of DNA polymerase gamma) are an important cause of mitochondrial disease. " 06/01/2015 - "Diseases due to mutations of POLG gene, encoding the mitochondrial DNA polymerase, are reputed to have very diverse clinical presentations and have been proposed to cause up to 25% adult mitochondrial diseases. "
4.	Parkinsonian Disorders (Parkinsonism) 08/01/2013 - "We conclude that the cell number in substantia nigra correlated well with parkinsonism in DNA polymerase gamma and Twinkle defects. " 08/01/2013 - "However, parkinsonism associates typically with defects of catalytic domain of mitochondrial DNA polymerase gamma. " 01/01/2012 - "Association of mitochondrial DNA polymerase γ gene POLG1 polymorphisms with parkinsonism in Chinese populations." 09/04/2004 - "Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study." 08/01/2013 - "We show here that all patients with mitochondrial DNA maintenance disorders had neuronopathy in substantia nigra, most severe in DNA polymerase gamma-associated parkinsonism. "
5.	HIV Infections (HIV Infection) 03/02/1991 - "Depletion of muscle mtDNA is probably due to zidovudine-induced inhibition of mtDNA replication by DNA polymerase gamma and is not a secondary effect of HIV infection." 01/01/2016 - "Mechanistic studies have shown that interactions of the primary mitochondrial DNA polymerase γ (mtDNA Pol γ) with nucleoside reverse transcriptase inhibitors (NRTIs), key components in treating HIV infection, are a major source of NRTI-associated toxicity. " 09/30/2006 - "Lipodystrophy, and the metabolic alterations (dislipemia, insulin-resistance) associated with human immunodeficiency virus (HIV) infection, is a multifactorial syndrome due to the interaction of host related factors (cellular immune status, diet, gene mutations), viral factors (cytokine synthesis, polyunsaturated fatty acid or PUFA depletion), and pharmacological effects (mitochondrial DNA-polymerase inhibition, lipolysis inhibition, adiponectin synthesis reduction). "

Related Drugs and Biologics

1.	Phytohemagglutinins
2.	DNA Polymerase I (Klenow Fragment)
3.	Mitochondrial DNA (mtDNA)
4.	DNA (Deoxyribonucleic Acid)
5.	Nucleosides
6.	Reverse Transcriptase Inhibitors
7.	Nucleotides
8.	Exonucleases (3' 5' Exonuclease)
9.	Glutamate Receptors (Glutamate Receptor)
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Therapeutics
2.	Highly Active Antiretroviral Therapy (HAART)