Phytohemagglutinins

Mucoproteins isolated from the kidney bean (Phaseolus vulgaris); some of them are mitogenic to lymphocytes, others agglutinate all or certain types of erythrocytes or lymphocytes. They are used mainly in the study of immune mechanisms and in cell culture.

Also Known As:

Hemagglutinins, Plant; Lectin, Kidney Bean; Lectin, Phaseolus vulgaris; Lectins, Phaseolus vulgaris; Plant Hemagglutinins; Kidney Bean Lectin; Kidney Bean Lectins; Lectins, Kidney Bean; Phaseolus vulgaris Lectin; Phaseolus vulgaris Lectins; Phytohemagglutinin

Networked: 1944 relevant articles (41 outcomes, 160 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Luo, Ying: 7 articles (01/2022 - 01/2018)
2.	Sun, Ziyong: 7 articles (01/2022 - 01/2018)
3.	Wang, Feng: 7 articles (01/2022 - 01/2018)
4.	Tang, Guoxing: 6 articles (01/2022 - 01/2020)
5.	Xue, Ying: 6 articles (01/2022 - 01/2020)
6.	Mao, Liyan: 6 articles (04/2021 - 01/2018)
7.	Song, Huijuan: 5 articles (01/2022 - 08/2020)
8.	Yuan, Xu: 5 articles (01/2022 - 01/2020)
9.	Lin, Qun: 5 articles (04/2021 - 01/2020)
10.	Moore, C B: 5 articles (05/2003 - 07/2000)

Related Diseases

1.	Leukemia 02/01/1984 - "Feeder cell requirements for leukemia cell colony formation in cultures supplemented with phytohemagglutinin." 08/01/1982 - "At the onset of the leukemia 15.4% of peripheral blood cells stimulated with phytohemagglutinin (PHA) contained a tandem translocation of the long arm of chromosome #14, i.e., t(14;14). " 09/01/1979 - "Isolates of Penicillium canescens, Curvularia, Fusarium sambucinum, Fusarium equiseti and Trichoderma koningii from the leukemia-associated house depressed the responses to phytohemagglutinin, but none of the fungal isolates obtained from a nearby control house depressed responses to phytohemagglutinin. " 09/01/1979 - "Suppression of phytohemagglutinin response by fungi from a "leukemia" house." 06/01/1978 - "[The prognostic value of lymphocyte transformation by phytohemagglutinin in children with acute lymphatic leukemia]."
2.	Neoplasms (Cancer) 05/01/2013 - "In the present study, phytohemagglutinin (PHA) was used to stimulate peripheral blood mononuclear cells (PBMCs) to simulate the tumor inflammatory microenvironment. " 01/01/1985 - "Relationship between lymphocytic cytotoxicity and phytohemagglutinin-induced lymphoblastogenesis before and after surgical tumor excision: an experimental study." 02/15/1984 - "In previous in vitro studies, the authors showed that phytohemagglutinin (PHA) stimulated peripheral blood lymphocytes (PBL) from cancer patients to generate cells that were lytic for fresh autologous tumor but not for lymphocytes or lymphoblasts. " 11/01/1980 - "[A study on the treatment of neoplasms with phytohemagglutinin (PHA) (author's transl)]." 08/15/1970 - "[Usefulness of studies of the blastic transformation of lymphocytes in phytohemagglutinin-stimulated cultures for the diagnosis of mediastinal tumors]."
3.	Hodgkin Disease (Hodgkin's Disease) 01/01/1984 - "Lymphocyte proliferation (LP) by phytohemagglutinin (PHA) and two suppressor systems of mononuclear cells was investigated in 22 patients with Hodgkin's disease (HD) who were apparently cured at the time of study. " 01/01/1968 - "[Studies on the influence of plasma in Hodgkin's disease on phytohemagglutinin transformation of normal lymphocytes]." 04/01/1985 - "Patients with active Hodgkin's disease (HD) often demonstrate an impaired T-cell proliferative response to phytohemagglutinin (PHA). " 03/01/1981 - "This assay was utilized to determine whether T cells (in the absence of monocytes and serum inhibitory factors) from patients with Hodgkin's disease were defective in their ability to proliferative in response to optimal (50 microgram/ml) and suboptimal (25 and 12.5 microgram/ml) concentrations of phytohemagglutinin. " 03/01/1981 - "Abnormal phytohemagglutinin-induced T-cell proliferative responses in Hodgkin's disease."
4.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/01/1986 - "The cellular immunity of 49 children between the ages of five months and 17 years with acute lymphoblastic leukemia (ALL) in remission was studied in vitro by stimulating the lymphocyte cultures with phytohemagglutinin (PHA). " 01/01/1986 - "Determining prognosis in childhood acute lymphoblastic leukemia by phytohemagglutinin (PHA) stimulated lymphocytes." 01/01/1979 - "Delayed mitogenic responses to phytohemagglutinin in acute lymphoblastic leukemia." 02/11/1971 - "[Phytohemagglutinin and acute lymphoblastic leukemia. " 08/01/1992 - "The production of colony-stimulating activity (CSA) by phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) from patients receiving maintenance chemotherapy for acute lymphoblastic leukemia (ALL) was examined. "
5.	Infections 01/01/2015 - "Therefore, the aim of this study was to investigate the progress of EHV-1 replication in leukocytes stimulated by phytohemagglutinin and the impact of EHV-1 infection on the actin cytoskeleton. " 09/01/1983 - "This study examined the kinetics and mechanisms of depressed spleen cell responses to phytohemagglutinin (PHA) that occur during Leishmania donovani infection of BALB/c mice. " 01/01/2019 - "The primary endpoint was concanavalin (Con A)- or phytohemagglutinin (PHA)-stimulated lymphocyte proliferation on postoperative day (POD) 7, which is an index of cell-mediated immunity; the secondary endpoint was the postoperative infection rate. " 02/01/2016 - "To do this, we assessed the impact of the natural parasite community and the experimental infection with Eimeria sp. on the phytohemagglutinin (PHA)-response, as well as other immune, condition, nutrition, and stress parameters. " 02/01/2011 - "Cellular substrate (CS) composed of phytohemagglutinin (PHA)-stimulated PBMNCs is required for isolating primary human immunodeficiency virus Type 1 from plasma (PHIV) during early acute infection. "

Related Drugs and Biologics

1.	Mitogens
2.	Antigens
3.	Concanavalin A
4.	Cytokines
5.	Interleukin-2 (IL2)
6.	Lipopolysaccharides
7.	Estrogens (Estrogen)
8.	Conditioned Culture Media
9.	Dinitrochlorobenzene (DNCB)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Transplantation
4.	Splenectomy
5.	High-Energy Radiotherapy (Radiotherapy, High Energy)