Placenta Growth Factor

An angiogenic protein belonging to the Vascular Endothelial Growth Factor family of growth factors originally isolated and cloned from human placental cDNA library. There are four isoforms of PLGF 1-4 which result from alternative splicing. Placenta Growth Factor is secreted as a glycosylated homodimer which acts as a mitogen for endothelial cells, and its expression is markedly upregulated during hypoxia and in tissue inflammation and cancer.

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Networked: 211 relevant articles (1 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kalra, Vijay K: 11 articles (01/2018 - 08/2003)
2.	Malik, Punam: 10 articles (01/2018 - 08/2003)
3.	Lacal, Pedro Miguel: 6 articles (02/2020 - 08/2006)
4.	Cheng, Shih-Lung: 6 articles (01/2018 - 09/2011)
5.	Hsieh, Fon-Jou: 6 articles (09/2009 - 02/2004)
6.	Cheng, Shih-Jung: 5 articles (01/2022 - 10/2010)
7.	Ahmed, Asif: 5 articles (11/2021 - 12/2003)
8.	Tsao, Po-Nien: 5 articles (01/2019 - 02/2004)
9.	Wei, Shu-Chen: 5 articles (01/2019 - 02/2004)
10.	Yu, Chong-Jen: 5 articles (01/2018 - 02/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2015 - "Prognostic significance of placenta growth factor expression in patients with multiple cancers: a meta-analysis." 10/01/2010 - "Expression of placenta growth factor (PlGF) is found to correlate with the progression and prognosis of several human cancers. " 09/01/2009 - "When we use the median level (20.6 pg/ml) of preoperative serum placenta growth factor as a cutoff point, the sensitivity, specificity, and positive predictive value for tumor recurrence and survival was 80, 54, 80% and 70, 56, 70%, respectively. " 05/01/1998 - "The basic residues of placenta growth factor type 2 retrieve sequestered angiogenic factors into a soluble form: implications for tumor angiogenesis." 01/01/2015 - "Placenta growth factor is upregulated in many neoplastic diseases and serum levels of PlGF are increased in cancer patients following anti-angiogenic therapy. "
2.	Pre-Eclampsia (Preeclampsia) 10/01/2001 - "Previous studies have shown decreased levels of placenta growth factor in serum of pregnant women with preeclampsia. " 12/01/2017 - "To investigate the role of maternal serum placenta growth factor (PlGF) and quadruple test parameters in predicting the risk of small for gestational age (SGA) infants of mothers without preeclampsia. " 08/01/2012 - "Decreased levels of serum placenta growth factor (PlGF) are associated with preeclampsia. " 08/01/2012 - "Examining the correlation between placental and serum placenta growth factor in preeclampsia." 08/01/2007 - "Second-trimester placenta growth factor levels are altered in patients who had severe preeclampsia develop."
3.	Fetal Growth Retardation (Intrauterine Growth Retardation) 10/01/2001 - "The aim of this study was to investigate whether levels of placenta growth factor are decreased before the clinical onset of preeclampsia, and whether placenta growth factor levels are decreased in pregnancies complicated by intrauterine growth restriction. " 10/01/2001 - "First-trimester maternal serum levels of placenta growth factor as predictor of preeclampsia and fetal growth restriction." 10/01/2001 - "The data suggest that placenta growth factor may be useful to determine the relative risk of developing preeclampsia and intrauterine growth restriction." 02/01/1999 - "Hypoxia down-regulates placenta growth factor, whereas fetal growth restriction up-regulates placenta growth factor expression: molecular evidence for "placental hyperoxia" in intrauterine growth restriction." 01/01/2023 - "Preeclampsia and fetal growth restriction (FGR) are both associated with an increased ratio of sFLT1 (soluble fms-like tyrosine kinase-1) to PlGF (placenta growth factor) in maternal serum. "
4.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2019 - "Using serum placenta growth factor could improve the sensitivity of colorectal cancer screening in fecal occult blood negative population: A multicenter with independent cohort validation study." 12/01/2012 - "Expression of placenta growth factor in colorectal carcinomas." 04/01/2012 - "Elevated serum placenta growth factor levels are significantly associated with colorectal cancer development, lymph or distant invasive phenotypes and survival, especially in stage II or III patients." 04/01/2012 - "The serum placenta growth factor levels in colorectal cancer patients were compared with those in healthy controls, and we retrospectively assessed the association between serum placenta growth factor levels and clinicopathological findings and survival. " 04/01/2012 - "Preoperative serum placenta growth factor level as a new marker for stage II or III colorectal cancer patients."
5.	Sickle Cell Anemia (Hemoglobin S Disease) 01/01/2018 - "Placenta growth factor mediated gene regulation in sickle cell disease." 03/11/2010 - "Placenta growth factor (PlGF) is released by immature erythrocytes and is elevated in sickle cell disease (SCD). " 08/15/2003 - "Placenta growth factor activates monocytes and correlates with sickle cell disease severity." 07/08/2010 - "High levels of placenta growth factor in sickle cell disease promote pulmonary hypertension." 01/01/2014 - "The aim of this study was to assess the clinical significance of Thrombospondin and Placenta growth factor profiles in patients with sickle cell disease. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)
4.	Tyrosine (L-Tyrosine)
5.	Prostaglandins F
6.	Pregnancy-Associated Plasma Protein-A (PAPP-A)
7.	Carcinoembryonic Antigen
8.	Intercellular Signaling Peptides and Proteins (Growth Factors)
9.	Angiogenesis Inducing Agents (Angiogenesis Factor)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Radioimmunotherapy