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Carcinoembryonic Antigen

A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
Also Known As:
Antigen, CD66e; Antigen, Carcinoembryonic; CD66e Antigens; Antigens, CD66e; CD66e Antigen
Networked: 9651 relevant articles (258 outcomes, 1067 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Goldenberg, David M: 39 articles (01/2021 - 02/2002)
2. Schlom, Jeffrey: 27 articles (09/2017 - 01/2002)
3. Sharkey, Robert M: 20 articles (01/2021 - 05/2002)
4. Yang, Shung-Haur: 19 articles (01/2021 - 01/2002)
5. Bouvet, Michael: 18 articles (12/2021 - 11/2008)
6. Shively, John E: 17 articles (12/2022 - 12/2003)
7. Li, Yan: 17 articles (05/2022 - 11/2007)
8. Baba, Hideo: 17 articles (01/2022 - 11/2005)
9. Tomita, Masaki: 17 articles (07/2020 - 04/2004)
10. Lee, Woo Yong: 16 articles (01/2022 - 08/2007)

Related Diseases

1. Neoplasms (Cancer)
01/01/2013 - "In the past, several factors, such as an advanced primary T stage, the primary N+ status, a large tumor size, multiple tumors, a disease-free interval of <12 months, an elevated carcinoembryonic antigen level, the presence of an extrahepatic disease, and the margin width (<1 cm) and status (positive), have been recognized to predict poor outcomes, but most of them lack the sensitivity for accurate individual prognostication. "
11/01/2023 - "The correlation among parameters D90, gender, pathological pattern, age, maximum tumor diameter, Metabolic Tumor Volume (MTV), SUVmax, SUVpeak, SUVmean, Total Lesion Glycolysis (TLG), High metabolic tumor cell ratio (HMR) and Carcinoembryonic antigen(CEA)with short-term efficacy of I125-SI was analyzed by two independent-sample t-test, Mann-Whitney U test or Chi-squared test and binary logistic regression. "
06/01/2012 - "In this particular system targeting carcinoembryonic antigen, a small-molecule-binding affinity of 400 pmol/L was sufficient to achieve maximal tumor targeting, and an improvement in affinity to 10 pmol/L showed no significant improvement in tumor uptake at 24 hours postinjection. "
02/01/2008 - "Using nodal status of the primary tumor, disease-free interval, size of the largest metastatic tumor, preoperative carcinoembryonic antigen, bilateral resection, extensive resection (lobectomy or more), gender, number of hepatic tumors, primary cancer site (colon vs. rectum), and age, the nomogram achieved a concordance index of 0.61, statistically significantly greater than chance. "
07/01/2019 - "Fluid could be aspirated from 50 % of the cystic tumors, all with a carcinoembryonic antigen level < 192 ng/mL. With surgical pathology as the gold standard, overall sensitivity of EUS-FNA in diagnosing cystic tumors was 62.5 %, and for solid tumors, 95 % ( P  < 0.03). "
2. Neoplasm Metastasis (Metastasis)
03/01/1995 - "Patients with a normal carcinoembryonic antigen level (</=3 mm/liter), those without bone metastases, older women, and those with a long disease-free interval were most likely to benefit from treatment. "
07/01/1991 - "Age of patient, site of primary, disease-free interval between treatment of primary and of hepatic metastases, preoperative carcinoembryonic antigen levels, and number of metastases, did not relate to prognosis, while sex (P = 0.024), stage of primary (P = 0.026), extent of liver involvement (P less than 0.001), distribution of metastases (P = 0.01) and type of surgery (P = 0.028) significantly affected prognosis as single factors. "
11/01/2016 - "Although many prog- nostic factors have been reported, recent major studies and meta-analysis suggested that the following 4 indicators were promising prognostic factors: (1) number of metastasis, (2) disease-free interval, (3) preoperative serum carcinoembryonic antigen(CEA) level, and (4) hilar/mediastinal nodal status. "
01/01/2022 - "Patients with bilateral, more than one pulmonary metastasis, abnormal postmetastasectomy carcinoembryonic antigen (CEA), history of liver metastasis, and disease-free interval (DFI) ≤12 months had worse OS. "
12/01/2007 - "Following resection favourable prognostic factors include a long disease-free interval, small number and small size of metastases, a normal carcinoembryonic antigen level, and an absence of concomitant liver metastases and mediastinal lymph node spread. "
3. Colorectal Neoplasms (Colorectal Cancer)
4. Carcinoma (Carcinomatosis)
5. Colonic Neoplasms (Colon Cancer)

Related Drugs and Biologics

1. Antigens
2. Carbohydrates
3. Monoclonal Antibodies
4. Tumor Biomarkers (Tumor Markers)
5. Phosphopyruvate Hydratase (Enolase)
6. Keratin-19 (Keratin 19)
7. Biomarkers (Surrogate Marker)
8. Antibodies
9. Keratins (Keratin)
10. alpha-Fetoproteins (alpha-Fetoprotein)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Therapeutics
3. Radioimmunotherapy
4. Immunotherapy
5. Chemoradiotherapy