Second-trimester angiogenic factors as biomarkers for future-onset preeclampsia.

Abstract

OBJECTIVE:

The purpose of this study was to determine whether second-trimester soluble fms-like tyrosine kinase-1 and placenta growth factor (PlGF) are altered in patients who have preeclampsia develop compared with controls. Furthermore, soluble fms-like tyrosine kinase-1 and placenta growth factor levels in patients with chronic hypertension are described.

STUDY DESIGN:

With the use of a research database, 21 patients who had severe preeclampsia develop, 34 controls, and 9 patients with chronic hypertension were enrolled. Placenta growth factor and soluble fms-like tyrosine kinase-1 serum levels were determined by enzyme-linked immunosorbent assay. Appropriate statistical tests were used and results were reported as median (quartile 1-quartile 3) in picograms per milliliter.

RESULTS:

Placenta growth factor was significantly lower in patients in the second trimester who later had severe preeclampsia develop but soluble fms-like tyrosine kinase-1 was unchanged compared with healthy pregnancies. In patients with chronic hypertension, placenta growth factor and soluble fms-like tyrosine kinase-1 levels were not different compared with controls.

CONCLUSION:

Second-trimester placenta growth factor levels are altered in patients who had severe preeclampsia develop.

• Authors: E Ramsey Unal, Christopher J Robinson, Donna D Johnson, Eugene Y Chang
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 197 Issue 2 Pg. 211.e1-4 (Aug 2007) ISSN: 1097-6868 [Electronic] United States
• PMID: 17689655 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Angiogenesis Inducing Agents
• Biomarkers
• PGF protein, human
• Pregnancy Proteins
• Placenta Growth Factor
• FLT1 protein, human
• Vascular Endothelial Growth Factor Receptor-1

Topics

• Adult
• Angiogenesis Inducing Agents (blood)
• Biomarkers
• Female
• Humans
• Hypertension (blood)
• Placenta Growth Factor
• Pre-Eclampsia (blood)
• Pregnancy
• Pregnancy Proteins (blood)
• Pregnancy Trimester, Second
• Vascular Endothelial Growth Factor Receptor-1 (blood)