Expression of placenta growth factor: an independent factor for prediction of progression and prognosis of oral cancer.

Abstract

BACKGROUND:

Expression of placenta growth factor (PlGF) is found to correlate with the progression and prognosis of several human cancers.

METHODS:

This study used an immunohistochemical technique to examine the expression of PlGF in 100 specimens of oral squamous cell carcinoma (OSCC).

RESULTS:

We found that the higher mean PlGF labeling index was significantly associated with OSCCs with positive lymph node metastasis (p = .014) or with more advanced clinical stages (p = .016). Positive lymph node metastasis (p = .008) and PlGF labeling index >40% (p = .010) were identified as independent unfavorable prognosis factors by multivariate analyses with Cox regression model. Moreover, a Kaplan-Meier curve showed that OSCC patients with a PlGF labeling index >40% had a significantly poorer cumulative survival than those with a PlGF labeling index ≤40% (log-rank test, p = .003).

CONCLUSIONS:

The PlGF labeling index can predict the progression and prognosis of OSCCs in Taiwan.

• Authors: Shih-Jung Cheng, Jang-Jaer Lee, Sang-Heng Kok, Chia-Hsuan Chou, Hao-Hueng Chang, Meng Ling Chiang, Hsin-Ming Chen, Mark Yen-Ping Kuo, Chun-Pin Chiang
• Journal: Head & neck (Head Neck) Vol. 32 Issue 10 Pg. 1363-9 (Oct 2010) ISSN: 1097-0347 [Electronic] United States
• PMID: 20091685 (Publication Type: Journal Article)
• Copyright: © 2010 Wiley Periodicals, Inc.

Chemical References

• PGF protein, human
• Pregnancy Proteins
• Placenta Growth Factor

Topics

• Adult
• Aged
• Carcinoma, Squamous Cell (metabolism, mortality, pathology)
• Case-Control Studies
• Disease Progression
• Female
• Humans
• Immunohistochemistry
• Kaplan-Meier Estimate
• Lymphatic Metastasis
• Male
• Middle Aged
• Mouth Neoplasms (metabolism, mortality, pathology)
• Multivariate Analysis
• Placenta Growth Factor
• Pregnancy Proteins (metabolism)
• Prognosis