Abstract | PURPOSE: METHODS: RESULTS: Serum placenta growth factor, but not vascular endothelial growth factor, increased; sFlt-1 decreased in patients with preoperative colorectal cancer, compared with healthy controls. Higher preoperation serum placenta growth factor levels were associated with higher risk of recurrence. Preoperation serum placenta growth factor, but not carcinoembryonic antigen, was a prognostic indicator in patients with Stage III colorectal cancer. When we use the median level (20.6 pg/ml) of preoperative serum placenta growth factor as a cutoff point, the sensitivity, specificity, and positive predictive value for tumor recurrence and survival was 80, 54, 80% and 70, 56, 70%, respectively. CONCLUSIONS:
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Authors | Shu-Chen Wei, Jin-Tung Liang, Po-Nien Tsao, Fon-Jou Hsieh, Sen-Chang Yu, Jau-Min Wong |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 52
Issue 9
Pg. 1630-6
(Sep 2009)
ISSN: 1530-0358 [Electronic] United States |
PMID | 19690493
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carcinoembryonic Antigen
- PGF protein, human
- Pregnancy Proteins
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Placenta Growth Factor
- FLT1 protein, human
- Vascular Endothelial Growth Factor Receptor-1
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoembryonic Antigen
(blood)
- Case-Control Studies
- Cohort Studies
- Colonic Neoplasms
(blood, diagnosis, mortality)
- Female
- Humans
- Male
- Middle Aged
- Placenta Growth Factor
- Predictive Value of Tests
- Pregnancy Proteins
(blood)
- Prognosis
- Rectal Neoplasms
(blood, diagnosis, mortality)
- Vascular Endothelial Growth Factor A
(blood)
- Vascular Endothelial Growth Factor Receptor-1
(blood)
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