Prostaglandins F (PGF)

(9 alpha,11 alpha,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid (PGF(1 alpha)); (5Z,9 alpha,11,alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid (PGF(2 alpha)); (5Z,9 alpha,11 alpha,13E,15S,17Z)-9,11,15-trihydroxyprosta-5,13,17-trien-1-oic acid (PGF(3 alpha)). A family of prostaglandins that includes three of the six naturally occurring prostaglandins. All naturally occurring PGF have an alpha configuration at the 9-carbon position. They stimulate uterine and bronchial smooth muscle and are often used as oxytocics.

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Networked: 480 relevant articles (15 outcomes, 50 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Basu, Samar: 11 articles (01/2015 - 06/2005)
2.	Jabbour, Henry N: 7 articles (08/2011 - 02/2004)
3.	Yamahara, Johji: 5 articles (01/2012 - 06/2005)
4.	Li, Yuhao: 5 articles (01/2012 - 06/2005)
5.	Larsson, Anders: 4 articles (01/2015 - 06/2005)
6.	Souza, Glória E P: 4 articles (12/2011 - 01/2006)
7.	Sales, Kurt J: 4 articles (12/2009 - 02/2004)
8.	Basu, S: 4 articles (01/2009 - 12/2000)
9.	Narumiya, Shuh: 3 articles (10/2012 - 05/2005)
10.	Sheldon, I M: 3 articles (08/2010 - 09/2009)

Related Diseases

1.	Endometritis 05/01/2013 - "Because of a wide discordance between research results, a meta-analysis of the efficacy of the treatment of bovine endometritis with PGF(2α) was conducted. " 05/01/2013 - "The objective of the conducted meta-analysis was to assess the efficacy of the treatment of bovine endometritis with PGF(2α) by statistical means. " 05/01/2013 - "Furthermore, there is a shortage of comparable high quality studies investigating reproductive performance after PGF(2α) treatment of cows with chronic endometritis." 08/01/2012 - "The objective of this study was to evaluate the quality and comparability of published literature, and to summarize the effect of prostaglandin F(2α) (PGF(2α)) for the treatment of endometritis. " 02/01/2008 - "An endometrial explant culture was developed that measured PGF(2alpha) and may be used to study endometritis."
2.	Wounds and Injuries (Trauma) 01/01/2011 - "The results of this study suggest that in Asian eyes with shallow anterior chambers, surgical trauma relating to the technique of donor insertion, and the use of a small donor are major risk factors for PGF following DSAEK." 09/01/1995 - "Patients who have trauma with high risk for PE should be considered for PGF placement." 09/01/1995 - "PGF insertion in selected patients at high risk who had trauma effectively prevented both fatal and nonfatal PE. " 01/01/1976 - "Spinal trauma led to more than a 100% increase in PGF levels to 29.26 +/- 3.58. " 09/01/1995 - "The purpose of this study was to evaluate the safety and efficacy of prophylactic Greenfield filter (PGF) placement in patients who have multiple trauma with known high-risk injuries for PE. "
3.	Cardiovascular Diseases (Cardiovascular Disease) 01/01/2012 - "Several studies have revealed an important role of PGF primarily in pathological conditions (e.g.: ischaemia, tumour formation, cardiovascular diseases and inflammatory processes) suggesting its use as a potential therapeutic agent. " 01/21/2015 - "The results are in line with the emerging evidence of the importance of the inflammatory mediator PGF(2α) in fatal cardiovascular disease." 01/01/2009 - "This study investigates the impact of genetic variation in the cyclooxygenase-1 (COX-1) gene on formation of the vasoconstrictive, pro-inflammatory prostaglandin F(2)(alpha) (PGF(2)(alpha)) and development of cardiovascular disease (CVD). " 11/01/2010 - "These findings suggest a non-renal mechanism for the vascular protective effects of aldosterone antagonists in humans and support targeting the vascular aldosterone/MR/PGF/Flt1 pathway as a therapeutic strategy for ischemic cardiovascular disease."
4.	Pre-Eclampsia (Preeclampsia) 01/01/2015 - "In the first trimester, maternal serum sFLT1, PGF and ADMA levels, as well as second-trimester uterine artery PI, could predict preeclampsia." 01/01/2015 - "Multiple logistic regression and receiver-operating characteristic curves identified first-trimester PGF and ADMA to be sensitive and selective predictors of preeclampsia (area under the curve [AUC]: 0.902), as well as second-trimester uterine artery pulse index (AUC: 0.836). " 01/01/2015 - "First-trimester serum PGF levels of women who developed preeclampsia were significantly lower than in women with normal pregnancies (115.72 ± 32.55 vs. 217.30 ± 74.48 pg/ml, P < 0.001). " 01/01/2015 - "To investigate sFLT1, PGF and ADMA in the first trimester of pregnancy as predictors of preeclampsia. " 01/01/2015 - "Abnormal maternal sFLT1, PGF and ADMA levels are detectable weeks before the onset of preeclampsia. "
5.	Uterine Diseases (Endometrial Disease) 12/01/2009 - "Plasma PGF 2 alpha metabolite levels in cats with uterine disease." 12/01/2009 - "Uterine disease induces PGF(2 alpha) increase in many animal species, which can be measured by the metabolite 15-keto-(13,14)-dihydro-PGF(2 alpha) (PGFM). " 04/01/2009 - "In conclusion, LPS detection by endometrial cells stimulated the accumulation of PGE rather than PGF, providing a mechanism to explain prolonged luteal phases in animals with uterine disease, and this PGE may also be important for regulating inflammatory responses in the endometrium." 03/01/2011 - "The objectives of this study were to assess the efficacy of antibiotic treatment for preventing postpartum uterine disease among cows at high risk of uterine disease, and to assess the efficacy of PGF(2α) for treating cytological endometritis (CYTO) and purulent vaginal discharge (PVD). "

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2.	Progesterone
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4.	Serotonin (5 Hydroxytryptamine)
5.	Tissue Inhibitor of Metalloproteinase-2
6.	Neuropeptides
7.	Glycoproteins (Glycoprotein)
8.	Matrix Metalloproteinase 14 (MT1-MMP)
9.	Pravastatin (Pravachol)
10.	Troleandomycin (TAO)

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4.	Coronary Artery Bypass (Coronary Artery Bypass Surgery)
5.	Lung Transplantation