Abstract | BACKGROUND: Recent reports have suggested an involvement of neutrophilic inflammation driven by interleukin (IL)-17 from Th17 cells, especially in severe, refractory asthma. It remains unknown about the possible interactions of this cytokine and other proinflammatory cytokines to direct neutrophilic airway inflammation. MATERIALS AND METHODS: RESULTS: CONCLUSIONS:
IL-17A in the combination with TNF-α or IL-1β showed a synergistic augmenting effect on IL-8 and GM-CSF production in human airway epithelial cells.
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Authors | Kojiro Honda, Hiroo Wada, Masuo Nakamura, Keitaro Nakamoto, Toshiya Inui, Mitsuru Sada, Takashi Koide, Saori Takata, Takuma Yokoyama, Takeshi Saraya, Daisuke Kurai, Haruyuki Ishii, Hajime Goto, Hajime Takizawa |
Journal | Experimental lung research
(Exp Lung Res)
Vol. 42
Issue 4
Pg. 205-16
(05 2016)
ISSN: 1521-0499 [Electronic] England |
PMID | 27269887
(Publication Type: Journal Article)
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Chemical References |
- IL17A protein, human
- Interleukin-17
- Interleukin-8
- NF-kappa B
- Tumor Necrosis Factor-alpha
- Granulocyte-Macrophage Colony-Stimulating Factor
- Mitogen-Activated Protein Kinases
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Topics |
- Cells, Cultured
- Drug Synergism
- Epithelial Cells
(cytology, metabolism)
- Granulocyte-Macrophage Colony-Stimulating Factor
(biosynthesis, drug effects)
- Humans
- Inflammation
(etiology)
- Interleukin-17
(pharmacology)
- Interleukin-8
(biosynthesis, drug effects)
- Mitogen-Activated Protein Kinases
- NF-kappa B
(metabolism)
- Respiratory Mucosa
(cytology, metabolism)
- Signal Transduction
(drug effects)
- Tumor Necrosis Factor-alpha
(pharmacology)
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