Interleukins

Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli.

Also Known As:

Networked: 13596 relevant articles (285 outcomes, 1605 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fisher, Paul B: 58 articles (11/2015 - 08/2003)
2.	Sarkar, Devanand: 52 articles (11/2015 - 08/2003)
3.	Dent, Paul: 41 articles (02/2015 - 08/2003)
4.	Curiel, David T: 28 articles (08/2014 - 08/2004)
5.	Lebedeva, Irina V: 22 articles (09/2008 - 08/2003)
6.	Dinarello, Charles A: 21 articles (01/2014 - 02/2002)
7.	Iwakura, Yoichiro: 21 articles (01/2014 - 05/2002)
8.	Emdad, Luni: 20 articles (11/2015 - 10/2004)
9.	Grant, Steven: 20 articles (11/2013 - 08/2003)
10.	Das, Swadesh K: 16 articles (11/2015 - 05/2010)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2007 - "The aim of this study was to evaluate the clinical efficacy of infusion of high-dose interleukin (IL)-2-activated allogeneic haploidentical peripheral blood stem cells (haplo-PBSCTs) on patients with an advanced stage of refractory solid tumors. " 08/01/2007 - "We previously demonstrated that adoptively transferred, interleukin (IL)-2-activated natural killer (A-NK) cells are effective in reducing B16 lung tumors in tumor-bearing animals. " 10/01/1998 - "Direct activation of human cytotoxic T lymphocytes (CTL) by interleukin (IL)-18 was observed in a system in which CTL effective against autologous tumor cells were generated. " 07/01/2014 - "Such ICKs linking various antibody formats to interleukin (IL)-2 are currently being investigated in clinical trials and have shown promising results in cancer therapies. " 03/01/2006 - "By genetically manipulating bone marrow-derived neural stem-like cells (BM-NSC) to express a recently discovered cytokine, interleukin (IL)-23, the cells showed protective effects in intracranial tumor-bearing C57BL/6 mice. "
2.	Infection 03/01/2014 - "Recent genome wide association studies (GWAS) have shown important roles of single nucleotide polymorphisms (SNP) near region of interleukin B 28 (IL28B) gene in spontaneous and drug-induced clearance of hepatitis C virus (HCV) in genotype 1 HCV infection. " 01/01/2000 - "Although the involvement of T helper (Th1) cells is central to protection against intracellular bacteria, including Mycobacterium tuberculosis, the involvement of Th2 cells, characterized by potent interleukin (IL)-4 secretion in mycobacterial infection is still unclear. " 06/28/2013 - "However, expressions of all interleukins, iNOS and Ex-FABP showed that protection against homologous serovars was significantly higher than against heterologous serovars after intravenous challenge at 4 days post infection. " 03/17/2008 - "Herein, we confirmed that neutralization of the immunosuppressive factor interleukin (IL)-10 stimulated T cell responses and improved control of established persistent lymphocytic choriomeningitis virus (LCMV) infection. " 05/01/2015 - "Furthermore, the improved interleukin (IL)-17 response to infection in previously colonized mice was abolished by depletion of CD4+ cells, and prior colonization did not protect against lung infection in mice depleted of CD4+ cells or IL17. "
3.	Necrosis 01/01/2015 - "This study used in vivo microdialysis to examine the effects of intragingival application of lipopolysaccharide (LPS) derived from Porphyromonas gingivalis (Pg-LPS) on gingival tumour necrosis factor (TNF)-α and interleukin (IL)-6 levels in rats. " 09/01/2013 - "In accordance with earlier studies, we showed a significant increase in the C-fibre response and an upregulation of the gene expression of interleukin 1β and tumour necrosis factor 180 minutes after application of NP onto the nerve roots. " 10/01/1995 - "This study compared mortality rates, endotoxaemia, systemic tumour necrosis factor (TNF) and interleukin (IL)-6 concentrations after continuous and intermittent hepatic ischaemia. " 03/23/1993 - "In this study, the effects of tumour necrosis factor (TNF) and interleukins 1 alpha and 6 (IL-1 alpha and IL-6) on rat gastric fundus motility were investigated in vitro. " 09/04/1986 - "Our studies indicate that pretreatment of monocytes with alpha-IFN or gamma-IFN, and also interleukin (IL)-1 or tumour necrosis factor (TNF) results in enhanced monocyte cytotoxicity. "
4.	Inflammation 08/01/2006 - "In a variety of mouse models, chronic colon inflammation can be successfully treated with (interleukin) IL-10-secreting L. " 03/01/2009 - "By limiting the pulmonal inflammation cascade the anti-inflammatory cytokine interleukin (IL)-10 may have protective effects. " 06/01/2015 - "This study was designed to investigate the dual effect of NaF and BS on interleukin (IL)-1β-induced gingival inflammation. " 05/01/2015 - "The cytokine interleukin (IL)-23 promotes inflammation and helps to guide inflammatory cells, while studies have shown that the IL-23R gene is associated with susceptibility to several immune-related diseases. " 06/01/2014 - "This study investigated interleukin (IL)-17-secreting cell involvement in sterile inflammation, and evaluated the effect of mesenchymal stem cells (MSCs) on IL-17-secreting cell immunologic profiling. "
5.	Melanoma (Melanoma, Malignant) 11/01/2007 - "Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma." 03/01/2003 - "Adoptive immunotherapy with tumor infiltrating lymphocytes (TIL) and interleukin (IL)-2 is reasonably effective in the treatment of patients with advanced melanoma. " 09/01/2011 - "We compared the effect of intradermal versus intranodal administration of a DC vaccine on induction of immunologic responses in melanoma patients and examined whether concomitant administration of interleukin (IL)-2 increases the efficacy of the DC vaccine. " 12/20/2008 - "A phase I dose escalation trial of plasmid interleukin (IL)-12 electroporation was carried out in patients with metastatic melanoma. " 12/01/2005 - "In this study, we assessed the antitumor activity and autoimmune toxicity of CTLA-4 blockade in combination with an immune-activating stimulus, interleukin (IL)-2, in patients with metastatic melanoma. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Cytokines
3.	Interleukin-12 (IL 12)
4.	Interferons
5.	Interleukin-10 (Interleukin 10)
6.	Interleukin-6 (Interleukin 6)
7.	Interferon-gamma (Interferon, gamma)
8.	Interleukin-4 (Interleukin 4)
9.	Messenger RNA (mRNA)
10.	Interleukin-13

Related Therapies and Procedures

1.	Immunotherapy
2.	Drug Therapy (Chemotherapy)
3.	Aftercare (After-Treatment)
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
5.	Oral Administration