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Interleukin-17 (Interleukin 27)

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A proinflammatory cytokine produced primarily by T-LYMPHOCYTES or their precursors. Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.

Also Known As:

Interleukin 27; Interleukin 17; Interleukin 25; CTLA-8; CTLA8; Cytokine CX2; Cytokine ML-1; Cytotoxic T lymphocyte-Associated Antigen 8; IL-17A; IL-17B; IL-17C; IL-17D; IL-17E; IL-17F; Interleukin-17A; Interleukin-17B; Interleukin-17C; Interleukin-17D; Interleukin-17E; Interleukin-17F; Interleukin-25; Interleukin-27; CX2, Cytokine; Cytokine ML 1; Cytotoxic T lymphocyte Associated Antigen 8; IL 17E; Interleukin 17A; Interleukin 17B; Interleukin 17C; Interleukin 17D; Interleukin 17E; Interleukin 17F; IL-17

Networked: 4338 relevant articles (179 outcomes, 619 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Iwakura, Yoichiro: 84 articles (01/2015 - 09/2002)
2.	Kolls, Jay K: 61 articles (10/2015 - 01/2003)
3.	Gaffen, Sarah L: 36 articles (10/2015 - 01/2004)
4.	Dong, Chen: 31 articles (10/2015 - 03/2003)
5.	Miossec, Pierre: 25 articles (01/2015 - 03/2003)
6.	van den Berg, Wim B: 24 articles (01/2015 - 03/2003)
7.	Li, Xiaoxia: 23 articles (12/2015 - 03/2007)
8.	Lubberts, Erik: 22 articles (07/2015 - 03/2003)
9.	Nakae, Susumu: 21 articles (02/2015 - 09/2002)
10.	Joosten, Leo A B: 21 articles (08/2014 - 03/2003)

Related Diseases

1.	Infection 12/01/2014 - "Our results suggest that profound deficiency of IL-17 production associated with a marked decrease in Th17 cells likely contributes significantly to the increased susceptibility of human neonates to invasive bacterial and fungal infections." 01/01/2013 - "Th17 and IL-17 play important roles in the clearance of extracellular bacterial and fungal infections. " 01/01/2012 - "Murine genital tract infection with Neisseria gonorrhoeae has previously been found to induce IL-17 which is important in both recruitment of neutrophils and prompt clearance of the infection. " 02/01/2011 - "Proinflammatory cytokine gene expression in the stomach correlates with vaccine-induced protection against Helicobacter pylori infection in mice: an important role for interleukin-17 during the effector phase." 01/01/2012 - "Protection against H5N1 virus infection was obtained by adoptively transferring PZQ-primed wild type CD8(+) T cells and this was more effective than transfer of activated IFN-γ KO or IL-17 KO CD8(+) T cells. "
2.	Inflammation 04/15/2010 - "Therefore, preventing neutrophil recruitment by blocking the action of IL-17 on endothelial cells may prove to be highly beneficial in diseases in which neutrophilic inflammation plays a key role." 01/01/2015 - "Targeting both IFN-γ and IL-17 may be beneficial for treating the LG inflammation in SS." 12/01/2013 - "Similar to IL-17 or IL-23/p19 depletion, injection of diseased CD18(hypo) PL/J mice with anti-γδTCR Abs significantly reduced skin inflammation and largely eliminated pathological γδ and CD4(+) T cells. " 06/01/2012 - "IL-17 neutralization significantly ameliorates hepatic granulomatous inflammation and liver damage in Schistosoma japonicum infected mice." 09/01/2006 - "Moreover, significantly elevated in vitro production of IL-17, but not of IFN-gamma, correlated with the high pathology, and neutralization of IL-17 in vivo resulted in a significant reduction of hepatic inflammation. "
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 08/01/2013 - "However, Phase II results of IL-17 blockade with each of these agents has shown a marked improvement of disease severity, thus confirming the pathogenic relevance of IL-17 in mediating crucial inflammatory circuits in psoriasis. " 11/01/2014 - "This recent paradigm shift provides a plausible explanation for the rapid and strong efficacy of the novel compounds targeting IL-17 functions in psoriasis and other inflammatory disorders, and provide a more comprehensive view on the complex cytokine network in these conditions. " 07/24/2014 - "Secukinumab was effective for psoriasis in two randomized trials, validating interleukin-17A as a therapeutic target. " 03/01/2015 - "These encouraging results demonstrate the efficacy of these agents and validate the pro-inflammatory role of IL-17 in the pathophysiology of psoriasis." 10/27/2015 - "Thus, targeting IκBζ could be a future strategy for treatment of psoriasis, and other inflammatory diseases for which IL-17 antagonists are currently tested in clinical trials. "
4.	Neoplasms (Cancer) 10/01/2013 - "The DDX3X-primed CD4(+) T cells produced CD133(+) tumor-specific IFNγ and IL-17 and mediated potent antitumor therapeutic efficacy. " 01/01/2013 - "Consequently, depending on the effector or regulatory role of dendritic cells, blocking IL-17A, may be either dangerous or beneficial for cancer outcomes, thus contributing to the apparent controversy around the role of IL-17A in cancer." 07/01/2010 - "IL-17(-/-) mice exhibited a significant reduction of tumor growth, concomitantly with the decrease of vascular density at lesion area, indicating a pro-tumor property of IL-17. " 01/01/2013 - "In conclusion, blockade of IL-17A at tumor sites helped suppress tumor growth by inhibiting angiogenesis as well as cytotoxic T lymphocytes activation at tumor sites." 01/01/2013 - "Suppression of IL-17A at tumor sites led to a Th1-dominant environment, and moreover, eliminated myeloid-derived suppressor cells and regulatory T cells at tumor sites but not in splenocytes. "
5.	Colitis 01/01/2015 - "Therapeutic efficacy of IL-17A antibody injection in preventing the development of colitis associated carcinogenesis in mice." 01/01/2014 - "These results demonstrate that IL-17 confers protection against the development of severe colitis through the induction of an atypical M2-like macrophage subpopulation. " 01/01/2014 - "In the present study, by using IL-17 knockout (KO) mice, we investigated the role of IL-17 in colitis, with special focus on the macrophage subpopulations. " 01/01/2015 - "Our findings indicate that BTLA may be involved in the control of inflammatory responses through increasing Foxp3 expression, rather than attenuating IL-17 production, in DSS-induced colitis. " 01/01/2015 - "In a murine T cell transfer model of colitis, transfer of Tpl2-/- T cells resulted in reduced proportions of CD4 T cells expressing IFNγ, but not IL-17A, compared to that induced by wild type T cells. "

Related Drugs and Biologics

1.	Interleukin-17 (Interleukin 27)
2.	Cytokines
3.	Interleukin-23 (Interleukin 23)
4.	interleukin-22 (IL-22)
5.	Interleukin-6 (Interleukin 6)
6.	Interferon-gamma (Interferon, gamma)
7.	Interleukin-10 (Interleukin 10)
8.	Antibodies
9.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
10.	Interleukin-4 (Interleukin 4)

Related Therapies and Procedures

1.	Immunomodulation
2.	Ligation
3.	Drug Therapy (Chemotherapy)
4.	Biological Therapy
5.	Aftercare (After-Treatment)