Mitogen-Activated Protein Kinases

A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).

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Networked: 952 relevant articles (10 outcomes, 120 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bitto, Alessandra: 5 articles (11/2014 - 10/2006)
2.	Squadrito, Francesco: 5 articles (11/2014 - 10/2006)
3.	Altavilla, Domenica: 5 articles (11/2014 - 10/2006)
4.	Reich, Reuven: 5 articles (09/2006 - 01/2003)
5.	Davidson, Ben: 5 articles (09/2006 - 01/2003)
6.	Zhang, Li-Cai: 4 articles (11/2015 - 06/2008)
7.	Zhang, Lin: 4 articles (04/2012 - 02/2005)
8.	Polito, Francesca: 4 articles (10/2010 - 10/2006)
9.	Pothoulakis, C: 4 articles (09/2010 - 08/2000)
10.	Pintucci, Giuseppe: 4 articles (06/2009 - 09/2003)

Related Diseases

1.	Fibrosis (Cirrhosis) 01/01/2009 - "Mitogen activated protein kinases in renal fibrosis." 03/01/2007 - "In-vitro and animal studies have shown that increased receptor expression could be linked to high blood pressure and to cardiac and glomerular fibrosis by activating mitogen-activated protein kinases and by upregulating gene expression of profibrotic molecules. " 02/01/2013 - "Exploration of signaling pathways in Nampt-induced cardiac hypertrophy and fibrosis revealed increased activation of mitogen-activated protein kinases, namely, JNK1, p38, and ERK. " 09/01/2014 - "Astragaloside IV ameliorates renal fibrosis via the inhibition of mitogen-activated protein kinases and antiapoptosis in vivo and in vitro." 01/01/2016 - "Our intent is to draw attention to the possibility of signal transduction cascade modulation (e.g., Smad signal and mitogen-activated protein kinases, by gene transfer and other related technology) as being beneficial in a clinical setting to reduce or even prevent corneal stromal tissue fibrosis/scarring and inflammation. "
2.	Inflammation 11/27/2013 - "The mechanisms of PT-3 neuronal protection against inflammation may be associated with the mitogen-activated protein kinases (MAPK) pathway. " 10/01/2015 - "Real time PCR and Western blot were used to assess the level of inflammation factors and mitogen-activated protein kinases (MAPKs). " 09/01/2015 - "We evaluate the effects of a diet rich in fish oil in white adipose tissue (WAT) inflammation pathways, renin-angiotensin system (RAS) and mitogen-activated protein kinases (MAPKs). " 11/01/2014 - "TAK1 is known to control cell viability and inflammation through activating downstream effectors such as NF-κB and mitogen-activated protein kinases (MAPKs). " 05/01/2012 - "Mitogen-activated protein kinases (MAPKs) play a critical role in inflammation. "
3.	Pancreatitis 11/28/2014 - "Aim of this article is to review the role of mitogen-activated protein kinases in pathogenesis of acute pancreatitis. " 11/28/2014 - "Evidence for a role of mitogen-activated protein kinases in the treatment of experimental acute pancreatitis." 11/01/2009 - "Mitogen-activated protein kinases (MAPKs) are considered major signal transducers early during the development of acute pancreatitis. " 11/01/2007 - "Activated protein C, an anticoagulant polypeptide, ameliorates severe acute pancreatitis via regulation of mitogen-activated protein kinases." 08/01/2011 - "Potential role of NADPH oxidase-mediated activation of Jak2/Stat3 and mitogen-activated protein kinases and expression of TGF-β1 in the pathophysiology of acute pancreatitis."
4.	Melanoma (Melanoma, Malignant) 12/01/2014 - "Melanoma is primarily driven by mutations in the components of mitogen-activated protein kinases (MAPK) pathway. " 12/01/2013 - "Activation of the ERK1/2 mitogen-activated protein kinases (MAPK) confers resistance to the RAF inhibitors vemurafenib and dabrafenib in mutant BRAF-driven melanomas. " 03/01/2007 - "Since mitogen-activated protein kinases (MAPK) have been shown to be activated in most melanomas, we sought to analyze their possible involvement in CIITA expression. " 03/25/2004 - "Inactivation of p19Arf or p53 in carcinogen-induced melanomas was accompanied by constitutive activation of mitogen-activated protein kinases (MAPKs) and/or mutation-associated activation of N-ras. " 06/01/2002 - "POH treatment of melanoma cells in vitro reduced the levels of detectable Ras protein and inhibits the activation of downstream targets, mitogen-activated protein kinases and Akt. "
5.	Neoplasm Metastasis (Metastasis) 07/01/2012 - "In this study, we have investigated (i) the role of mitogen-activated protein kinases (MAPKs) and (ii) the therapeutic efficacy of the non-essential amino acid, l-glutamine (Gln), which evidences MAPKs inhibition activity in PAF-mediated B16F10 melanoma metastasis to the lungs. " 04/12/2007 - "This study investigated the role of TGF-beta type I receptor, ALK5, and three mitogen-activated protein kinases (MAPKs) in metastasis by breast cancer cell line MDA-MB-231. " 05/01/2004 - "Mitogen activated protein kinases are a family of kinases of different lineages that are thought to be important in tumor growth and metastasis. " 09/01/2013 - "The influence of distinct compounds on different signal transduction pathways (cell proliferation, survival, angiogenesis and metastasis) was screened via analysis of the activity of 24 protein kinases, mitogen activated protein kinase phosphorylation via Western blot, cytotoxicity was shown using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and determination of caspase activity. " 07/14/2011 - "The results suggest that a suboptimal concentration of curcumin augments the antitumor action of paclitaxel by downregulating the activation and downstream signaling of antiapoptotic factors and survival signals such as NF-κB, Akt and mitogen-activated protein kinases that have significant roles in proliferation, survival, angiogenesis and metastasis. "

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2.	Angiotensin II
3.	Transforming Growth Factor beta (TGF-beta)
4.	Losartan (Cozaar)
5.	Glutamine (L-Glutamine)
6.	Caerulein (Ceruletide)
7.	Protein C
8.	octyl caffeate
9.	rosiglitazone (Avandia)
10.	astragaloside A

Related Therapies and Procedures

1.	Dye Lasers
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Intra-Articular Injections
4.	Drug Therapy (Chemotherapy)
5.	Transplants (Transplant)