Abstract | PURPOSE: METHODS: Solid tumor mass was developed in female albino mice using Ehrlich carcinoma cells. Forty mice-bearing tumor were divided randomly into four groups for treatment: with saline, meloxicam 10 mg/kg, doxorubicin 5 mg/kg and meloxicam 1 h ahead of doxorubicin, twice weekly for 2 weeks. Tumor volume was followed up and cardiac protective utility was estimated via measuring heart and serum parameters. RESULTS: CONCLUSION:
Meloxicam protects heart against doxorubicin toxicity without affecting its antitumor activity against solid mammary cancer model in mice. This protective effect is attributed to antioxidant effect, antiradical effect, antiinflammatory action, antiapoptotic effect and induction of QR enzyme.
|
Authors | Memy H Hassan, Hesham A El-Beshbishy, Hamdy Aly, Sabry M Attia, Saleh A Bahashwan, Mohamed M Ghobara |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 74
Issue 3
Pg. 559-69
(Sep 2014)
ISSN: 1432-0843 [Electronic] Germany |
PMID | 25053391
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antibiotics, Antineoplastic
- Cyclooxygenase 2 Inhibitors
- Thiazines
- Thiazoles
- Doxorubicin
- L-Lactate Dehydrogenase
- Catalase
- Glutathione Peroxidase
- Superoxide Dismutase
- Caspase 3
- Glutathione
- Dinoprostone
- Meloxicam
|
Topics |
- Animals
- Antibiotics, Antineoplastic
(adverse effects, pharmacology)
- Caspase 3
(metabolism)
- Catalase
(genetics, metabolism)
- Cyclooxygenase 2 Inhibitors
(pharmacology)
- Dinoprostone
(metabolism)
- Doxorubicin
(adverse effects, pharmacology)
- Female
- Glutathione
(metabolism)
- Glutathione Peroxidase
(genetics, metabolism)
- Heart Diseases
(chemically induced, metabolism)
- L-Lactate Dehydrogenase
(genetics, metabolism)
- Lipid Peroxidation
(drug effects)
- Mammary Neoplasms, Experimental
(drug therapy, mortality, pathology)
- Meloxicam
- Mice
- Myocardium
(metabolism)
- Organ Size
(drug effects)
- Superoxide Dismutase
(genetics, metabolism)
- Thiazines
(pharmacology)
- Thiazoles
(pharmacology)
|