Meloxicam (Mobic)

A benzothiazine and thiazole derivative that acts as a NSAID and cyclooxygenase-2 (COX-2) inhibitor. It is used in the treatment of RHEUMATOID ARTHRITIS; OSTEOARTHRITIS; and ANKYLOSING SPONDYLITIS.

Also Known As:

Networked: 1041 relevant articles (165 outcomes, 271 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Coetzee, Johann F: 14 articles (03/2022 - 10/2011)
2.	Mack, Randall J: 12 articles (05/2021 - 01/2018)
3.	McCallum, Stewart W: 12 articles (05/2021 - 01/2018)
4.	Du, Wei: 12 articles (01/2021 - 01/2018)
5.	Freyer, Alex: 9 articles (01/2021 - 01/2018)
6.	Ishiguro, Naoki: 9 articles (12/2019 - 03/2006)
7.	Nishida, Yoshihiro: 9 articles (12/2019 - 03/2006)
8.	Flecknell, Paul A: 7 articles (01/2022 - 01/2003)
9.	Dong, Xiaofeng: 7 articles (12/2021 - 01/2014)
10.	Urakawa, Hiroshi: 7 articles (12/2019 - 02/2012)

Related Diseases

1.	Pain (Aches) 10/01/2018 - "SYXBD significantly improved physical function (P = 0.021), bodily pain (P = 0.002) and general health (P = 0.014), with no significant difference in role emotional (P = 0.053), role physical (P = 0.517), vitality (P = 0.241), social function (P = 0.712) and mental health (P = 0.800) in SF-36 compared to Meloxicam. " 06/01/2018 - "Meloxicam IV was associated with statistically significant differences over placebo on several other secondary endpoints, including other SPID intervals (ie, SPID12, SPID48, and SPID24-48), achievement of perceptible pain relief, the proportion of subjects with a ≥ 30% improvement in the first 24 hours, and Patient Global Assessment of pain at hour 48. " 03/01/2001 - "Meloxicam 7.5 mg and 15 mg significantly improved overall pain between baseline and day 7 (p < 0.05) compared with placebo. " 01/01/1998 - "Both meloxicam 7.5 mg and 15 mg were significantly more effective than placebo with respect to pain on movement (p < 0.01 and p < 0.03, respectively). " 01/01/2020 - "Compared to amelotex, movalis was more effective for the duration of pain intensity reduction (5±1,4 days (min 3, max 9) in the movalis group and 7,37±1,68 days (min 3, max 10) in the amelotex group) as well as for the total duration of temporary disability (labor losses 6,43±1,4 days (min 4, max 10) and 8,61±1,59 days (min 5, max 12), respectively). "
2.	Postoperative Pain 02/01/2022 - "The non-steroidal anti-inflammatory drug meloxicam may be beneficial in alleviating post-operative pain in mice, although no regimen has been demonstrated as universally efficacious owing to differences in experimental protocols, strain, sex, and incomplete descriptions of methodology in the literature. " 12/01/2019 - "In conclusion, preemptive meloxicam is more effective in postoperative pain control and equally tolerated compared with postoperative meloxicam in patients receiving AKS." 07/01/2015 - "Transmucosal delivery of meloxicam was found to be effective and safe in postsurgical pain control of periodontal flap surgery. " 06/01/2010 - "Changes in behavior suggest that meloxicam was effective for reducing post-surgical pain and distress associated with calf dehorning." 10/07/2009 - "To assess the efficacy of single dose oral meloxicam in acute postoperative pain, and any associated adverse events. "
3.	Osteoarthritis 10/01/2001 - "Results from this study suggest that oral meloxicam 7.5 mg for 28 days is a safe and effective treatment regimen with high GI tolerability profile for the treatment of osteoarthritis in Thai patients." 12/14/2019 - "Osteoarthritis rats experienced a significant reduction in TNF-α level after being given meloxicam at a dose of 10 mg/kg BW compared with the control group. " 10/01/2001 - "A prospective, open trial to evaluate the safety and efficacy of oral meloxicam 7.5 mg once daily over a period of 28 days in Thai patients with osteoarthritis was conducted in 3 major hospitals in Bangkok, Thailand. " 10/23/2000 - "In previous studies, meloxicam has been found to be safe and effective in the treatment of osteoarthritis (OA) at doses of 7.5 to 15 mg daily. " 10/23/2000 - "Safety and efficacy of meloxicam in the treatment of osteoarthritis: a 12-week, double-blind, multiple-dose, placebo-controlled trial. "
4.	Inflammation (Inflammations) 01/01/2016 - "Our main achievement was high accumulation of (99m) Tc-tricarbonyl-Meloxicam in the inflammated muscle in mice (T/NT = 3.90 at 4 h post injection) which may diagnostically be beneficial for distinguish sites of inflammation." 10/12/2023 - "Meloxicam delayed the clearance of pathogens by inhibiting pro-inflammatory processes, causing prolonged inflammation. " 01/01/2018 - "The objective of this study was to develop a more bio-available and safe nanosuspension of meloxicam (MX), which could dramatically improve inflammation targeting. " 10/12/2023 - "High-content immunohistochemistry was able to identify relevant meloxicam-mediated effects on inflammatory processes based on alterations in the regional structure of inflammation sites. " 03/01/2023 - "However, the link between meloxicam and uterine inflammation and oxidative stress in dairy cows has not been studied. "
5.	Arthritis (Polyarthritis) 10/01/2019 - "Meloxicam (MX), a nonsteroidal anti-inflammatory drug, widely used to treat arthritis, has a very bitter taste. " 10/01/2017 - "The PC extract or meloxicam were administered orally in CIA mice once a day for 14 days after arthritis induction. " 06/15/2017 - "The long term administration of Meloxicam for the management of arthritis, a chronic disorder, results in gastrointestinal disturbances leading to poor patient compliance. " 12/01/2009 - "RESULTS-Parrots treated with meloxicam at 1.0 mg/kg had significantly better return to normal (baseline) weight bearing on the arthritic pelvic limb, compared with control parrots or parrots treated with meloxicam at 0.05, 0.1, and 0.5 mg/kg. All fecal samples collected from parrots following induction of arthritis and treatment with meloxicam had negative results for occult blood. " 11/01/2004 - "Pharmacokinetic-pharmacodynamic relationships and dose response to meloxicam in horses with induced arthritis in the right carpal joint."

Related Drugs and Biologics

1.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)
2.	Analgesics (Analgesic Drugs)
3.	Diclofenac (SR 38)
4.	Piroxicam (Feldene)
5.	Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
6.	Naproxen (Naprosyn)
7.	Bupivacaine (Bupivacaine Hydrochloride)
8.	Tablets
9.	Ibuprofen (Motrin)
10.	Buprenorphine (Subutex)

Related Therapies and Procedures

1.	Therapeutics
2.	Castration
3.	Drug Therapy (Chemotherapy)
4.	Analgesia
5.	Injections