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Dinoprostone (PGE2)

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The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.

Also Known As:

PGE2; Prostaglandin E2; PGE2 alpha; Prepidil Gel; Prostaglandin E2 alpha; Prostenon; E2 alpha, Prostaglandin; E2, Prostaglandin; E2alpha, Prostaglandin; Gel, Prepidil; alpha, PGE2; alpha, Prostaglandin E2; PGE2alpha; Prostaglandin E2alpha; Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-

Networked: 7035 relevant articles (253 outcomes, 724 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Narumiya, Shuh: 18 articles (12/2015 - 11/2003)
2.	Jakobsson, Per-Johan: 18 articles (07/2015 - 07/2003)
3.	Dubinett, Steven M: 17 articles (09/2015 - 12/2002)
4.	Zhang, Li: 16 articles (01/2016 - 11/2007)
5.	DuBois, Raymond N: 15 articles (12/2015 - 09/2003)
6.	Levine, Jon D: 15 articles (09/2015 - 05/2003)
7.	Sharma, Sherven: 14 articles (05/2014 - 12/2002)
8.	Breyer, Richard M: 14 articles (11/2012 - 04/2002)
9.	Yang, Peiying: 13 articles (11/2015 - 12/2002)
10.	Dannenberg, Andrew J: 13 articles (11/2015 - 10/2002)

Related Diseases

1.	Inflammation 01/01/2014 - "In a mouse inflammation model, significant reduction of PGE2 efflux transport at the BBB has been observed. " 01/01/2008 - "Because implants with rough surfaces are acknowledged to be superior to those with smooth surfaces, these results suggest that use of nonsterioidal anti-inflammatory drugs to block PGE2 production and reduce inflammation may be beneficial in the postoperative period after implant placement. " 07/01/2001 - "SI-6601D improved local clinical symptoms in RA patients by suppressing PGE2 and, therefore, may be a useful treatment for local inflammation in RA." 01/01/1999 - "Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammation." 01/01/2015 - "However, blocking PGE2 or TGF-β eliminated the immunosuppressive effect of ASCs in allergic airway inflammation. "
2.	Neoplasms (Cancer) 05/01/2013 - "Moreover, the effect of combination treatment was associated with significant reduction of PGE2 in serum, which resulted from increased 15-PDGH and decreased COX-2 in tumor tissues. " 03/01/1995 - "Tissue levels of PGE2 were significantly greater in tumor and normal mucosal tissues compared to lymph nodes (p = 0.0003). " 03/01/1995 - "Although PGE2 may have adverse effects on local immune function in tumor tissues, improved survival of patients with increased local PGE2 production may be indicative of an enhanced immunologic response to the tumor which has a favorable impact on outcome." 09/01/2005 - "Our data suggest that the chemopreventive treatments were effective in inhibiting tumor development in NMBA-treated animals only when they reduced PGE2 levels in preneoplastic esophageal tissues approximately to those levels found in normal esophagus." 12/01/2014 - "This study, therefore, demonstrated that primary tumors can alter the lung microenvironment during the pre-metastatic phase by triggering an inﬂammatory response and PGE2 production. "
3.	Pain (Aches) 09/01/1998 - "Pretreatment with intracervical PGE2 gel increased pain associated with Laminaria placement and did not improve the efficacy of the procedure." 05/01/2011 - "Induction of labor and pain: a randomized trial between two vaginal preparations of dinoprostone in nulliparous women with an unfavorable cervix." 09/01/2007 - "As demonstrated in an ex vivo clinical study, these effects on pain relief may be due to reduced inflammatory cytokine production including lower prostaglandin E2 formation. " 05/01/2005 - "This strongly argues for a dose-finding study of PM extract in humans to corroborate the in vitro observed inhibitory activity on PGE2 production in order to resolve the potential use of PM extract in inflammatory disorders and/or inflammatory pain." 08/01/2015 - "In conclusion, we strongly suggest that the observed antihyperalgesic and antiinflammatory effects of P. amarus in current pain model are mediated via spinal or supraspinal neuronal mechanisms, mainly by inhibition of PGE2. "
4.	Rupture 05/01/1977 - "It is concluded that oral PGE2 is safe and effective for induction of labor in women with premature membrane rupture. " 01/01/2012 - "The efficacy of dinoprostone vaginal insert for active management of premature rupture of membranes at term: a randomized controlled trial." 04/01/2012 - "The purpose of the study was to assess the effectiveness of early labor induction with cervical prostaglandin E2 versus expectant management in women with term premature rupture of membrane. " 02/01/1992 - "Prelabour rupture of the membranes at term and unfavourable cervix; a randomized placebo-controlled trial on early intervention with intravaginal prostaglandin E2 gel." 09/01/1985 - "In a subsequent open study, 4 mg prostaglandin E2 gel was applied vaginally to 17 term pregnant women of mixed parity with premature rupture of the membranes and unfavorable cervixes. "
5.	Infection 07/01/2015 - "Furthermore suppressing PGE2 signaling by COX2 inhibition or EP2 inhibition exhibited protective effects against pulmonary infection as well. " 07/01/2015 - "In addition, the addition of exogenous PGE2 with ASCs abolished many of the protective effects of ASCs, and administrating PGE2 alone exacerbated lung infection. " 03/01/2014 - "In the present study, we found out that HP-PRRSV infection could increase PGE2 production by upregulation of COX-1, and we subsequently characterized the underlying mechanisms about how HP-PRRSV enhances COX-1 production. " 02/01/2010 - "Collectively, these studies underscore the pivotal role of KSHV induced COX-2/PGE2 in creating KS lesion like microenvironment during de novo infection. " 12/05/2005 - "In this study, we have investigated the mechanism of PGE2 production in airway epithelial cells, following respiratory syncytial virus (RSV) infection, and its role in viral replication. "

Related Drugs and Biologics

1.	Dinoprostone (PGE2)
2.	Indomethacin (Indometacin)
3.	Epoprostenol (Prostacyclin)
4.	Misoprostol (Cytotec)
5.	Prostaglandins
6.	Dinoprost
7.	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
8.	Alprostadil (Muse)
9.	Leukotriene B4
10.	Cyclooxygenase 2 (Cyclooxygenase-2)

Related Therapies and Procedures

1.	Oral Administration
2.	Immunotherapy
3.	Pessaries
4.	Hepatectomy
5.	Drug Therapy (Chemotherapy)