L-Lactate Dehydrogenase (Lactate Dehydrogenase)

A tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of LACTATE and PYRUVATE. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.

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Networked: 5797 relevant articles (151 outcomes, 348 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lippi, Giuseppe: 9 articles (02/2015 - 01/2011)
2.	Garbe, Claus: 8 articles (06/2014 - 04/2003)
3.	Li, Jian-Yong: 8 articles (09/2012 - 12/2007)
4.	Xu, Wei: 8 articles (09/2012 - 12/2007)
5.	Xia, Qiang: 8 articles (09/2006 - 05/2004)
6.	Wang, Wei: 7 articles (09/2015 - 02/2006)
7.	Gao, Feng: 7 articles (03/2015 - 03/2006)
8.	Lim, Kye-Taek: 7 articles (08/2014 - 03/2007)
9.	Roberts, Jenny R: 7 articles (08/2012 - 11/2002)
10.	Chen, Lei: 6 articles (10/2015 - 06/2010)

Related Diseases

1.	Ischemia 09/01/2011 - "It was found that ischemia for 6h induced a significant reduction in the number of neuronal cells and cell-viability, and an increase in lactate dehydrogenase (LDH) release and the percentage of apoptotic nuclei in neurons. " 08/01/2011 - "When challenged by in vivo or ex vivo ischemia/reperfusion (I/R), however, the CA-RhoA mice exhibited strikingly increased tolerance to injury, which was manifest as reduced myocardial lactate dehydrogenase (LDH) release and infarct size and improved contractile function. " 01/01/2005 - "In isolated rat hearts subjected to 30 min regional ischemia and 120 min reperfusion, pretreatment with Pue at 0.24 mmol/L for 5 min before ischemia increased myocardial formazan content, an index of myocardial viability, reduced lactate dehydrogenase release, improved recovery of the maximal rise/fall rate of left ventricular pressure, left ventricular end-diastolic pressure and rate-pressure product (left ventricular developed pressure multiplied by heart rate) during reperfusion. " 07/01/1968 - "[Study of renal and urinary lactate dehydrogenase (LDH) in chronic ischemia of kidney]." 08/01/2013 - "Lactate dehydrogenase assays showed that the cytotoxic effect of chemical ischemia on astrocytes began to appear at 2 h of ischemia. "
2.	Neoplasms (Cancer) 09/01/1986 - "The presence of high lactate dehydrogenase levels, large tumor size, and age over 60 years had a suggestive negative correlation with the achievement of complete remission. " 01/01/1982 - "Studied with Cox's proportional hazard model for multivariate analysis hCG in the primary tumor, serum lactate dehydrogenase, performance status, and complete remission had a significant impact on survival. " 12/01/1990 - "Statistically significant improvement in the overall survival and failure-free survival at 1 year has already been seen for the stage D patients (high tumor burden and high lactate dehydrogenase levels). " 10/01/2007 - "The efficacy of HFI in mediating tumor cell lysis was determined by colorimetric lactate dehydrogenase release assays. " 05/01/2001 - "Repression of the enzyme lactate dehydrogenase and the spontaneous remission or regression of cancer."
3.	Anoxia (Hypoxia) 07/01/2015 - "The results demonstrated that ALA pre- or post-treatment significantly reduced lactate dehydrogenase (LDH) release induced through hypoxia/reoxygenation in HUVECs in a dose-dependent manner; of note, 1 mM ALA pre- or post-treatment exhibited the most potent protective effects. " 10/01/2009 - "There was a significant reduction of percentage of lactate dehydrogenase released and a significant increase of percentage of cell viability in the hypoxia + reoxygenation + cytoprotectors groups compared to hypoxia + reoxygenation groups. " 11/27/1994 - "Further, in livers perfused under hypoxic conditions using a low-flow model, lactate dehydrogenase release in livers from fed rats (547 U/g/hr) was significantly greater than in livers from 4-day fasted rats (397 U/g/hr), indicating that fasting increased tolerance to hypoxia. " 06/01/2010 - "This study investigates the molecular mechanism by which yaks (Bos grunniens) adapt to hypoxia based on lactate dehydrogenase (LDH). " 05/01/1992 - "Despite substantial lactate dehydrogenase release during hypoxia (8 to 46%) and reoxygenation (8 to 11%), DHBA production did not exceed that of the coincubated, continuously oxygenated control PTS. In the second phase of the study, salicylate-treated rats were subjected to 25 or 40 min of renal arterial occlusion +/- 15 min of reperfusion. "
4.	Body Weight (Weight, Body) 06/01/2015 - "At a dosage that did not affect the body weight, numbers of leukocytes, and concentrations of lactate dehydrogenase and albumin in the bronchoalveolar lavage (BAL) fluids, the weight of the lungs increased. " 04/01/2015 - "Diplotypes were significantly associated with body weight at hatch, heart weight, pancreas weight, duodenum length, leg muscle fibre density and lactate dehydrogenase. " 12/23/2013 - "Conjugates showed no apparent toxicity in several analyses including body weight, serum lactate dehydrogenase level, necropsy analysis, and by histopathological examination of organs. " 12/01/2013 - "We observed that DOX exposure induced mortality elevation, body weight loss, and cardiac dysfunction in mice, increased lactate dehydrogenase leakage and cardiomyocyte apoptosis, but decreased cell viability and size in cardiac tissues and cultured H9c2 cells, respectively, which were effectively antagonized by SLD supplement. " 01/01/2011 - "cordifolia extract was tested for acute toxicity at the given dose (150 mg/kg body weight) by lactate dehydrogenase (LDH) assay. "
5.	Myocardial Infarction 10/01/2011 - "Using isolated perfused rat hearts, we found that IHH significantly improved the postischemic recovery of left ventricular (LV) contractile function with a concurrent reduction of lactate dehydrogenase release and myocardial infarct size (20.5 ± 5.3% in IHH vs. 42.1 ± 3.8% in the normoxic control, P < 0.01) after I/R. " 05/01/2012 - "The Cur treatment conferred a cardioprotective effect, and the treated hearts demonstrated an improved post-ischemic cardiac functional recovery, a decreased myocardial infarct size and decreased lactate dehydrogenase release in the coronary flow, a reduced number of apoptotic cardiomyocytes, up-regulation of the anti-apoptotic protein Bcl2 and down-regulation of the pro-apoptotic protein Caspase3. " 01/01/1991 - "In 319 patients who participated in a double-blind trial to evaluate the effect of early rt-PA administration compared to placebo in suspected acute myocardial infarction, infarct size was assessed from analyses of serum activity of lactate dehydrogenase isoenzyme 1 (LD 1). " 11/01/1982 - "A study of heart specific lactate dehydrogenase isoenzyme in acute myocardial infarction." 09/01/1980 - "[Experimental studies on sequential changes in the lactate dehydrogenase isoenzyme pattern in the ischemic myocardium after myocardial infarction (author's transl)]."

Related Drugs and Biologics

1.	Creatine Kinase (Creatine Phosphokinase)
2.	Aspartate Aminotransferases (Aspartate Transaminase)
3.	Alanine Transaminase (SGPT)
4.	Alkaline Phosphatase
5.	Adenosine Triphosphate (ATP)
6.	Glucose (Dextrose)
7.	Malondialdehyde (Propanedial)
8.	Insulin (Novolin)
9.	Lactic Acid
10.	ruberythric acid (AlP)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Aftercare (After-Treatment)
4.	Transplants (Transplant)
5.	Oral Administration