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Superoxide Dismutase

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An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.

Also Known As:

Ag-Zn Superoxide Dismutase; Cobalt Superoxide Dismutase; Cu-Superoxide Dismutase; Cuprozinc Superoxide Dismutase; Erythrocuprein; Fe-Superoxide Dismutase; Fe-Zn Superoxide Dismutase; Iron Superoxide Dismutase; Manganese Superoxide Dismutase; Mn-SOD; Mn-Superoxide Dismutase; Ag Zn Superoxide Dismutase; Cu Superoxide Dismutase; Cu Zn Superoxide Dismutase; Dismutase, Ag-Zn Superoxide; Dismutase, Cobalt Superoxide; Dismutase, Cu-Superoxide; Dismutase, Cu-Zn Superoxide; Dismutase, Cuprozinc Superoxide; Dismutase, Fe-Superoxide; Dismutase, Fe-Zn Superoxide; Dismutase, Iron Superoxide; Dismutase, Manganese Superoxide; Dismutase, Mn-Superoxide; Dismutase, Superoxide; Fe Superoxide Dismutase; Fe Zn Superoxide Dismutase; Mn SOD; Mn Superoxide Dismutase; Superoxide Dismutase, Ag-Zn; Superoxide Dismutase, Cobalt; Superoxide Dismutase, Cu-Zn; Superoxide Dismutase, Cuprozinc; Superoxide Dismutase, Fe-Zn; Superoxide Dismutase, Iron; Superoxide Dismutase, Manganese; Cu-Zn Superoxide Dismutase; Hemocuprein; Superoxide:superoxide oxidoreductase

Networked: 7977 relevant articles (281 outcomes, 907 trials/studies)

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Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Oxidoreductases: 9264
    - Superoxide Dismutase: 7977

Experts

1.	Chan, Pak H: 39 articles (02/2013 - 01/2002)
2.	Oberley, Larry W: 29 articles (02/2010 - 02/2002)
3.	Salvemini, Daniela: 22 articles (11/2013 - 06/2002)
4.	Oury, Tim D: 20 articles (10/2015 - 09/2002)
5.	Valentine, Joan Selverstone: 19 articles (12/2015 - 05/2002)
6.	Huang, Shyh-Shyun: 19 articles (04/2015 - 06/2010)
7.	Huang, Guan-Jhong: 19 articles (04/2015 - 06/2010)
8.	Cuzzocrea, Salvatore: 19 articles (11/2013 - 06/2002)
9.	Cleveland, Don W: 17 articles (04/2015 - 04/2002)
10.	Zhang, Xiang Yang: 17 articles (01/2015 - 01/2003)

Related Diseases

1.	Ischemia 01/01/1987 - "This study tested the hypothesis that administration of recombinant human superoxide dismutase (h-SOD) at the time of reflow after a period of prolonged global ischemia would result in improved recovery of myocardial metabolism and function by preventing or reducing a potentially harmful component of reperfusion. " 01/01/1987 - "In a rat model of ischemia- and reperfusion-induced kidney damage, the protective effects of human superoxide dismutase produced by genetic technology (hum-SOD) were compared to those of bovine superoxide dismutase (bov-SOD). " 01/01/1987 - "Comparison of the protective effects by human and bovine superoxide dismutase against ischemia- and reperfusion-induced impairment of kidney function in anesthetized rats." 11/01/1994 - "In this study we tested the efficacy of peg-superoxide dismutase (SOD) in a model of repeated ischemia in gerbils. " 07/01/2001 - "These results suggest that protection against mitochondrial alterations after ischemia through manganese superoxide dismutase and/or Bcl-2 expression may be related to induction of ischemic tolerance by repeated HBO pretreatment."
2.	Reperfusion Injury 10/01/1999 - "Superoxide dismutase (SOD) is a potent candidate for myocardial protection against ischemia-reperfusion injury; however, its clinical significance by means of exogenous administration remains controversial. " 07/01/2012 - "Serum superoxide dismutase activity was significantly higher in group 2 than in group 3. The ratios of bilateral testicular weight, mean seminiferous tubule diameter, and germinal epithelial cell thickness were significantly higher in group 5 than in group 4. Therapy with EGCG before reperfusion might exert protective effects via antioxidant activities in a rat experimental model of testicular ischemia-reperfusion injury." 03/01/1997 - "Furthermore, the hearts transfected with manganese-superoxide dismutase showed significant improvement in tolerance against ischemia reperfusion injury. " 03/01/1991 - "The results indicate that retroinfusion of superoxide dismutase into the great cardiac vein before reperfusion may be an effective treatment for the prevention of reperfusion injury, even in the absence of a well developed coronary collateral circulation. " 01/01/2003 - "This study confirms the protective effects of superoxide dismutase against ischemia-reperfusion injury. "
3.	Body Weight (Weight, Body) 05/01/2010 - "This study indicate that in comparison with non-irradiated controls, irradiation resulted in a significant reduction the spleen index (spleen weight/body weight 100), haematological parameters (RBC, WBC and PLT), activity of superoxide dismutase (SOD), and increase of malondialdehde (MDA) level in 28 days. " 01/01/2015 - "Body weight, red blood cells (RBC), haemoglobin (Hb), haematocrit, and superoxide dismutase (SOD) also significantly increased in the FSM + omega-3 group. " 01/01/2012 - "There were significant increases (P < 0.05) in the levels of serum and liver superoxide dismutase of infected mice treated with 200 mg/kg body weight of A. " 06/01/2010 - "AR administration caused statistically significant decreases in body-weight, epididymal sperm concentration, testicular superoxide dismutase activity, diameters of seminiferous tubules, germinal cell layer thickness and Johnsen's testicular score, and increases in relative weights of testis, epidydimis and seminal vesicles, rates of abnormal sperm and apoptotic cell expression along with degeneration, desquamation and disorganization in spermatogenic cells, and interstitial oedema and congestion in testicular tissue. " 10/01/2009 - "Mn-SOD expression in the liver and kidney were significantly modulated by injection of LPS (1, 5, or 10 microg g(-1) body weight), Edwardsiella tarda challenge (5 x 10(3) or 5 x 10(5) cells/fish), and heavy metal exposure (Cd, Cu, or Zn at 5 microM). "
4.	Inflammation 07/01/2005 - "Superoxide dismutase (SOD) is supposed to be an effective agent for neutrophil-mediated inflammation in the area of critical medicine. " 09/15/2008 - "In this study, the expression of an antioxidant enzyme, extracellular superoxide dismutase (EC-SOD), and its protective role against pulmonary oxidative damage were investigated using mouse models of systemic inflammation. " 03/01/2015 - "Results showed that, although inflammation was not present in the cortex of 10-day-old double mutant MPSIIIB/TLR4(-/-) mice, the enzymatic activity of total superoxide dismutase (SOD) was already greater than in control animals. " 09/01/2014 - "We hypothesized that extracellular superoxide dismutase (SOD)3, an antioxidant uniquely targeted to the extracellular matrix (ECM) and alveolar fluid, might have a different response (down-regulation) to hyperoxic injury and recovery in room air (RA), thereby contributing to the persistent airspace injury and inflammation. " 07/01/2013 - "At a dose of 1.5 mg/kg, CP alleviated the histological evidence of inflammation and altered superoxide dismutase activity. "
5.	Neoplasms (Cancer) 03/01/1992 - "Mimicking of superoxide dismutase activity by protein-bound polysaccharide of Coriolus versicolor QUEL, and oxidative stress relief for cancer patients." 10/01/2010 - "The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue. " 06/01/2010 - "Since it was first observed in late 1970s that human cancers often had decreased manganese superoxide dismutase (MnSOD) protein expression and activity, extensive studies have been conducted to verify the association between MnSOD and cancer. " 01/01/2010 - "Earlier experimental studies have demonstrated that: i) Cu,Zn-superoxide dismutase deficiency leads to oxidative stress and carcinogenesis; ii) dysregulation of NF-κB pathway can mediate a wide variety of diseases, including cancer. " 01/08/2009 - "Several studies have demonstrated that cancer cells have lowered superoxide dismutase (MnSOD) activity and protein levels. "

Related Drugs and Biologics

1.	Catalase
2.	Glutathione Peroxidase
3.	Malondialdehyde (Propanedial)
4.	Enzymes
5.	Glutathione (Reduced Glutathione)
6.	Oxygen
7.	Copper
8.	Zinc
9.	Superoxides (Superoxide)
10.	Free Radicals

Related Therapies and Procedures

1.	Oral Administration
2.	Aftercare (After-Treatment)
3.	Cardiopulmonary Bypass (Heart-Lung Bypass)
4.	Transplants (Transplant)
5.	Lasers (Laser)